Alginate Oligosaccharides Prevent Dextran-Sulfate-Sodium-Induced Ulcerative Colitis via Enhancing Intestinal Barrier Function and Modulating Gut Microbiota [PDF]
Foods, 2023 Alginate oligosaccharides are degradation products of alginate and have attracted increasing attention due to their versatile biological functions.
Axue Wu +6 more
doaj +4 more sources
Alginate oligosaccharides can maintain activities of lysosomes under low pH condition [PDF]
Scientific Reports, 2021 The objective of this study was to report that lysosome extracted from egg white could be used as a drug through oral administration for treating diseases by using pH sensitive alginate oligosaccharides.
Ra-Mi Park +4 more
doaj +5 more sources
Expression, Purification, and Characterisation of Recombinant Alginate Lyase (Flammeovirga AL2) for the Bioconversion of Alginate into Alginate Oligosaccharides [PDF]
MoleculesAlginate, a polysaccharide found in brown seaweeds, has regularly gained attention for its potential use as a source of bioactive compounds. However, it is structurally complex with a high molecular weight, limiting its application.
Coleen E. Grobler +4 more
doaj +4 more sources
Enzymatic Hydrolysis of Alginate to Produce Oligosaccharides by a New Purified Endo-Type Alginate Lyase [PDF]
Marine Drugs, 2016 Enzymatic hydrolysis of sodium alginate to produce alginate oligosaccharides has drawn increasing attention due to its advantages of containing a wild reaction condition, excellent gel properties and specific products easy for purification.
Benwei Zhu +4 more
doaj +5 more sources
Alginate Oligosaccharides Affect Mechanical Properties and Antifungal Activity of Alginate Buccal Films with Posaconazole. [PDF]
Mar Drugs, 2019 Sodium alginate and its oligosaccharides through potential antifungal properties might improve the activity of antifungal drugs enhancing their efficacy and potentially reducing the frequency of application. Mucoadhesive buccal films are oral dosage forms designed for maintaining both local or systemic drug effects and seem to be a very promising ...
Szekalska M +4 more
europepmc +7 more sources
Production of Alginate Oligosaccharides (AOSs) Using Enhanced Physicochemical Properties of Immobilized Alginate Lyase for Industrial Application [PDF]
Marine DrugsAlginate lyase (AL) is a polysaccharide-degrading enzyme that can degrade alginate by hydrolyzing glycosidic bonds and produces unsaturated alginate oligosaccharides (AOSs). These AOSs have wide therapeutic and nutraceutical applications.
Simranjeet Kaur +3 more
doaj +4 more sources
A Recombinant Alginate Lyase Algt1 with Potential in Preparing Alginate Oligosaccharides at High-Concentration Substrate. [PDF]
Foods, 2023 Alginate lyase has been demonstrated as an efficient tool in the preparation of functional oligosaccharides (AOS) from alginate. The high viscosity resulting from the high concentration of alginate poses a limiting factor affecting enzymatic hydrolysis, particularly in the preparation of the fragments with low degrees of polymerization (DP).
Liang Q +9 more
europepmc +4 more sources
A Novel Cold-Adapted and High-Alkaline Alginate Lyase with Potential for Alginate Oligosaccharides Preparation. [PDF]
Molecules, 2023 Alginate oligosaccharides (AOs) prepared through enzymatic reaction by diverse alginate lyases under relatively controllable and moderate conditions possess versatile biological activities. But widely used commercial alginate lyases are still rather rare due to their poor properties (e.g., lower activity, worse thermostability, ion tolerance, etc.). In
Wang HY +5 more
europepmc +4 more sources
Advances in Research on the Bioactivity of Alginate Oligosaccharides. [PDF]
Mar Drugs, 2020 Alginate is a natural polysaccharide present in various marine brown seaweeds. Alginate oligosaccharide (AOS) is a degradation product of alginate, which has received increasing attention due to its low molecular weight and promising biological activity. The wide-ranging biological activity of AOS is closely related to the diversity of their structures.
Xing M +7 more
europepmc +5 more sources
Potential applications of alginate oligosaccharides for biomedicine – A mini review
Carbohydrate Polymers, 2021 Extensive research on marine algae, especially on their health-promoting properties, has been conducted. Various ingredients with potential biomedical applications have been discovered and extracted from marine algae. Alginate oligosaccharides are low molecular weight alginate polysaccharides present in cell walls of brown algae.
Mingpeng, Wang +2 more
openaire +4 more sources