Results 61 to 70 of about 6,238,484 (290)
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
A Hybrid Quantum Encoding Algorithm of Vector Quantization for Image Compression
, 2006 Many classical encoding algorithms of Vector Quantization (VQ) of image compression that can obtain global optimal solution have computational complexity O(N).
Grover L K +11 more
core +1 more source
Molecular Oncology, EarlyView.The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués +3 more
wiley +1 more source
Proceedings of the 50th Annual ACM SIGACT Symposium on Theory of Computing, 2018 The approximate degree of a Boolean function $f(x_{1},x_{2},\ldots,x_{n})$ is the minimum degree of a real polynomial that approximates $f$ pointwise within $1/3$. Upper bounds on approximate degree have a variety of applications in learning theory, differential privacy, and algorithm design in general.
openaire +3 more sources
Algorithmic thermodynamics [PDF]
Mathematical Structures in Computer Science, 2012 Algorithmic entropy can be viewed as a special case of the entropy studied in statistical mechanics. This viewpoint allows us to apply many techniques developed for use in thermodynamics to the subject of algorithmic information theory. In particular, suppose we fix a universal prefix-free Turing machine and letXbe the set of programs that halt for ...
BAEZ, JOHN, STAY, MIKE
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Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source
Target Association of Heterogeneous Sensors Based on Nearest-neighbor and Topology
Leida xuebao, 2012 A new data association algorithm is proposed in this paper for heterogeneous sensors information fusion system, which consists of Radar and high-dynamic-range IR, based on joint usage of the nearest-neighbor (NN) and the topology similarity. The proposed
Yuan Ding-bo +3 more
doaj +1 more source
Journal of Comparative Effectiveness Research, 2023 Aim: To compare the length of stay, hospital costs and hospital revenues for Medicare patients with and without a subset of potentially preventable postoperative complications after major noncardiac surgery.
Samer Haidar +2 more
doaj +1 more source
The Computer Journal, 1987 Algorithms are derived for allocating and deallocating blocks of memory using binary buddy, weighted buddy and variant weighted buddy partitioning; and transformations are demonstrated for converting recursive into non-recursive forms. Algorithms are given for the relatively difficult computation of the addressed and size of a buddy slot in the ...
Challab, D. J., Roberts, J. D.
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Next‐generation proteomics improves lung cancer risk prediction
Molecular Oncology, EarlyView.This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj +4 more
wiley +1 more source