Results 81 to 90 of about 386,495 (263)
Algorithmic Networks: central time to trigger expected emergent open-endedness
, 2019 This article investigates emergence and complexity in complex systems that can share information on a network. To this end, we use a theoretical approach from information theory, computability theory, and complex networks. One key studied question is how
Abrahão, Felipe S. +2 more
core +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Optimizing Energy Storage Systems. A Dynamic Framework For Capacity Allocation And profit Maximization In Electricity Markets [PDF]
Ovidius University Annals: Economic Sciences SeriesThis paper presents an algorithmic approach for optimizing energy storage system (ESS) capacity allocation across multiple electricity markets to maximize profits.
Adela Bara, Simona-Vasilica Oprea
doaj
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
A guideline for understanding and measuring algorithmic governance in everyday life
Internet Policy Review, 2019 Algorithmic governance affects individuals’ reality construction and consequently social order in societies. Vague concepts of algorithmic governance and the lack of comprehensive empirical insights into this kind of institutional steering by software ...
Michael Latzer, Noemi Festic
doaj +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Trees with the most subtrees -- an algorithmic approach
, 2012 When considering the number of subtrees of trees, the extremal structures which maximize this number among binary trees and trees with a given maximum degree lead to some interesting facts that correlate to other graphical indices in applications.
Gray, Daniel +3 more
core +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Defining Complex Adaptive Systems: An Algorithmic Approach
SystemsDespite a profusion of literature on complex adaptive system (CAS) definitions, it is still challenging to definitely answer whether a given system is or is not a CAS.
Muhammad Ayyaz Ahmad +2 more
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris +10 more
wiley +1 more source