Results 51 to 60 of about 52,658 (295)

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

The Impact of Algorithmic Governance on Consumer Responses: The Role of Territorial Psychological Ownership

Journal of Theoretical and Applied Electronic Commerce Research
This study explores the effects of algorithmic governance on consumer responses, with a particular focus on the role of territorial psychological ownership (TPO) as a moderator.
John Yang
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

The Threat of Algocracy: Reality, Resistance and Accommodation [PDF]

, 2016
One of the most noticeable trends in recent years has been the increasing reliance of public decision-making processes on algorithms, i.e. computer-programmed step-by-step instructions for taking a given set of inputs and producing an output.
Danaher, John
core   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Post-SUNEDU evolution: a national model of quality assurance driven by AI-based institutional monitoring

Frontiers in Education
The restructuring of Peru’s National Superintendence for University Education (SUNEDU) has reopened fundamental debates about regulatory legitimacy, institutional autonomy, and social justice in higher education.
Walter Stalin Gil Quevedo, Abraham William Garcia Chapoñan, Moises Luis Cornelio Vicuña   +2 more
doaj   +1 more source

Internet Utopianism and the Practical Inevitability of Law [PDF]

, 2019
Writing at the dawn of the digital era, John Perry Barlow proclaimed cyberspace to be a new domain of pure freedom. Addressing the nations of the world, he cautioned that their laws, which were “based on matter,” simply did not speak to conduct in the ...
Cohen, Julie E.
core   +2 more sources

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Foucauldian Biopolitics and Homo virtualis in the Context of Anticipatory Governance, Algorithms, and Transhumanism

Philosophies
This article examines contemporary forms of algorithmic governance through a biopolitical framework grounded in Michel Foucault’s analysis of security, risk, and governmentality. Rather than treating algorithmic systems as a rupture with earlier modes of
Mariam Margaryan, Aghavni Harutyunyan, Silva Petrosyan, Ashot Gevorgyan, Hayarpi Sahakyan   +4 more
doaj   +1 more source

Governing Algorithms

Science, Technology, & Human Values, 2015
Algorithms have developed into somewhat of a modern myth. On the one hand, they have been depicted as powerful entities that rule, sort, govern, shape, or otherwise control our lives. On the other hand, their alleged obscurity and inscrutability make it difficult to understand what exactly is at stake.
openaire   +2 more sources