Results 31 to 40 of about 8,117 (256)

From access and transparency to refusal: Three responses to algorithmic governance

Internet Policy Review, 2023
In this paper, we identify three responses evident in the dialogue regarding the emergence and development of data driven algorithmic governance. The first two responses, ones of access, inclusion and transparency, seek to remedy harms produced by the ...
Alexandra James, Danielle Hynes, Andrew Whelan, Tanja Dreher, Justine Humphry   +4 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Administrative sovereignty in the age of algorithmic governance: challenges and prospects for policy autonomy of the BRICS states

RUDN Journal of Public Administration
Governments worldwide are increasingly turning to artificial intelligence (AI) and algorithmic systems to improve service delivery, manage resources, and respond to citizens’ needs. These tools promise efficiency, precision, and cost savings, making them
Bhargav R. Moundekar, Gauri S. Sharma
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Mapping Data-Driven Governance in Sharing Economy Platforms: Algorithmic Management, Platform Control, and Value-Creation Mechanisms

Data
Research on sharing economy platforms has expanded rapidly, yet the literature remains fragmented across studies on platform business models, gig work, algorithmic management, trust, reputation systems, artificial intelligence, and data-driven value ...
Maria-Francisca Blasco-Lopez, Ramón Alberto Carrasco, Sulaiman Krayem   +2 more
doaj   +1 more source

Digital Environmentalism: A Legal and Moral Perspective on Climate Governance in the Age of Data and AI [PDF]

E3S Web of Conferences
Digital environmentalism, defined as the integration of big data and artificial intelligence (AI) into environmental policy, offers substantial potential to enhance emission monitoring, resource management, and climate change mitigation.
Mujiyana
doaj   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Counter-Surveillance Art in the Age of Platform Capitalism: Critical Complicity or Radical Exteriority?

Connessioni remote
Contemporary surveillance regimes no longer rely on concealment but operate through hypervisibility, subsuming subjects into networks of algorithmic governance where exposure functions as a mode of control. The present article interrogates the aesthetic
Massimiliano Raffa
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source