Results 41 to 50 of about 1,963 (247)
Random walk Metropolis algorithm in high dimension with non-Gaussian target distributions
Stochastic Processes and their Applications, 2020 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
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Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA
FEBS Open Bio, EarlyView.Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley +1 more source
The Algorithm of Chaos: WL and Random Dimensions
This paper explores the theoretical construct of "WL," a hypothetical world governed entirely by randomness, devoid of compliance with established laws. In WL, randomness is not entirely without structure, and its governing principles introduce profound implications for dimensions, time, life, and permanence.
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Dual native G‐quadruplex folding is associated with chromatin looping at the MYC locus
FEBS Open Bio, EarlyView.BG4‐detectable G‐quadruplex (G4) in HaCaT and NHEK keratinocytes identified folded and unfolded G4s enriched at promoters/TSSs and active enhancers, whereas unfolded G4s also overlapped weak/poised enhancers. At MYC–PVT1, 3C‐qPCR detected enhancer–promoter looping only when G4s were simultaneously folded at both regulatory elements under native ...
Dieila Giomo de Lima +7 more
wiley +1 more source
An Algorithmic Information Calculus for Causal Discovery and Reprogramming Systems
, 2017 We introduce a new conceptual framework and a model-based interventional calculus to steer, manipulate, and reconstruct the dynamics and generating mechanisms of non-linear dynamical systems from partial and disordered observations based on the ...
Hector Zenil +7 more
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FEBS Open Bio, EarlyView.In this study, a novel esterase from the thermoacidophilic archaeon Thermoplasma acidophilum was biochemically and structurally characterized. Our results demonstrate that Ta0887 is a highly thermostable esterase that preferentially hydrolyzes p‐nitrophenyl hexanoate and possesses an α‐helical cap domain that likely contributes to its substrate ...
Alejandro Delgado‐Rey +4 more
wiley +1 more source
SPDE limits of the random walk Metropolis algorithm in high dimensions [PDF]
, 2009 Diffusion limits of MCMC methods in high dimensions provide a useful\ud theoretical tool for studying efficiency. In particular they facilitate precise estimates of\ud the number of steps required to explore the target measure, in stationarity, as a function\ud of the dimension of the state space.
Mattingly, Jonathan C. +2 more
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Aging and Cancer, EarlyView.Cancer treatment is associated with measurable acceleration of biological aging across epigenetic, telomere, senescence, and immune biomarkers. However, biomarker validation and interventional strategies remain limited, especially in hematologic malignancies, underscoring the need for standardized multi‐omic aging assessments and adequately powered ...
Moataz Ellithi +3 more
wiley +1 more source
Using the Information Provided by Forbidden Ordinal Patterns in Permutation Entropy to Reinforce Time Series Discrimination Capabilities [PDF]
, 2020 [EN] Despite its widely tested and proven usefulness, there is still room for improvement in the basic permutation entropy (PE) algorithm, as several subsequent studies have demonstrated in recent years.
Cuesta Frau, David, David Cuesta-Frau
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