Results 91 to 100 of about 5,009,966 (344)

Combinatorial optimization in networks with Shared Risk Link Groups [PDF]

Discrete Mathematics & Theoretical Computer Science, 2016
The notion of Shared Risk Link Groups (SRLG) captures survivability issues when a set of links of a network may fail simultaneously. The theory of survivable network design relies on basic combinatorial objects that are rather easy to compute in the ...
David Coudert, Stéphane Pérennes, Hervé Rivano, Marie-Emilie Voge   +3 more
doaj   +1 more source

Inhibitor of DNA binding‐1 is a key regulator of cancer cell vasculogenic mimicry

Molecular Oncology, EarlyView.
Elevated expression of transcriptional regulator inhibitor of DNA binding 1 (ID1) promoted cancer cell‐mediated vasculogenic mimicry (VM) through regulation of pro‐angiogenic and pro‐cancerous genes (e.g. VE‐cadherin (CDH5), TIE2, MMP9, DKK1). Higher ID1 expression also increased metastases to the lung and the liver.
Emma J. Thompson, Emma L. Dorward, Kristyn Jurrius, Nathalie Nataren, Markus Tondl, Kay K. Myo Min, Michaelia P. Cockshell, Anahita Fouladzadeh, John Toubia, Mark DeNichilo, Delphine Merino, Claudine S. Bonder   +11 more
wiley   +1 more source

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

Molecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani, Gilgi Friedlander, Gili Perry, Nora Balint‐Lahat, Shlomit Gilad, Dana Morzaev‐Sulzbach, Anjana Shenoy, Noa Bossel Ben‐Moshe, Anya Pavlovsky, Rinat Bernstein‐Molho, Eytan Domany, Iris Barshack, Tamar Geiger, Bella Kaufman, Einav Nili Gal‐Yam   +14 more
wiley   +1 more source

Analyzing variational quantum landscapes with information content

npj Quantum Information
The parameters of the quantum circuit in a variational quantum algorithm induce a landscape that contains the relevant information regarding its optimization hardness.
Adrián Pérez-Salinas, Hao Wang, Xavier Bonet-Monroig   +2 more
doaj   +1 more source

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

Molecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez, Pablo Juanes‐Velasco, Marina L. García‐Vaquero, Conrad Droste, Alicia Landeira‐Viñuela, Miguel Alcoceba, Helena Fidalgo‐Gómez, Sara Misiego‐Herrero, Almudena Navarro‐Bailón, Mónica Baile, José M. Bastida, Jose Manuel Sanchez‐Santos, Rafael Góngora, Julia Almeida, Marcos Gonzalez‐Diaz, Alberto Orfao, Javier De Las Rivas, Manuel Fuentes   +17 more
wiley   +1 more source

Shadows of quantum machine learning

Nature Communications
Quantum machine learning is often highlighted as one of the most promising practical applications for which quantum computers could provide a computational advantage.
Sofiene Jerbi, Casper Gyurik, Simon C. Marshall, Riccardo Molteni, Vedran Dunjko   +4 more
doaj   +1 more source

Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data

Molecular Oncology, EarlyView.
This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu, Katherine Eason, Suet‐Feung Chin, Paul A. W. Edwards, Raquel Manzano Garcia, Richard Moulange, Jia Wern Pan, Soo Hwang Teo, Sach Mukherjee, Maurizio Callari, Carlos Caldas, Stephen‐John Sammut, Oscar M. Rueda   +12 more
wiley   +1 more source

Evaluating the Alzheimer's disease data landscape

Alzheimer’s & Dementia: Translational Research & Clinical Interventions, 2020
Introduction Numerous studies have collected Alzheimer's disease (AD) cohort data sets. To achieve reproducible, robust results in data‐driven approaches, an evaluation of the present data landscape is vital.
Colin Birkenbihl, Yasamin Salimi, Daniel Domingo‐Fernándéz, Simon Lovestone, AddNeuroMed consortium, Holger Fröhlich, Martin Hofmann‐Apitius, the Japanese Alzheimer's Disease Neuroimaging Initiative, and the Alzheimer's Disease Neuroimaging Initiative   +8 more
doaj   +1 more source

Ten Digit Algorithms [PDF]

, 2005
This paper was presented as the A R Mitchell Lecture at the 2005 Dundee Biennial Conference on Numerical Analysis, 27 June ...
Trefethen, Lloyd N.
core  

Algorithms for envelope estimation

, 2014
Envelopes were recently proposed as methods for reducing estimative variation in multivariate linear regression. Estimation of an envelope usually involves optimization over Grassmann manifolds. We propose a fast and widely applicable one-dimensional (1D)
Cook, R. Dennis, Zhang, Xin
core   +2 more sources