Results 81 to 90 of about 4,174,426 (295)
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
, 2005 We review and analyze the hybrid quantum-classical NMR computing methodology referred to as Type-II quantum computing. We show that all such algorithms considered so far within this paradigm are equivalent to some classical lattice-Boltzmann scheme.
Berman +17 more
core +2 more sources
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Algorithms for Coloring Quadtrees
, 1999 We describe simple linear time algorithms for coloring the squares of balanced and unbalanced quadtrees so that no two adjacent squares are given the same color.
Bern, Marshall W. +2 more
core +2 more sources
IEEE Transactions on Information Theory, 2001 LaTeX, 22 pages, 1 figure, with correction to the published journal ...
P. Gacs (Péter) +2 more
openaire +6 more sources
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
On minimal blocking sets of the generalized quadrangle $Q(4, q)$ [PDF]
Discrete Mathematics & Theoretical Computer Science, 2005 The generalized quadrangle $Q(4,q)$ arising from the parabolic quadric in $PG(4,q)$ always has an ovoid. It is not known whether a minimal blocking set of size smaller than $q^2 + q$ (which is not an ovoid) exists in $Q(4,q)$, $q$ odd. We present results
Miroslava Cimráková, Veerle Fack
doaj +1 more source
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
Exponential quantum advantages in learning quantum observables from classical data
npj Quantum InformationQuantum computers are believed to bring computational advantages in simulating quantum many-body systems. However, recent works have shown that classical machine learning algorithms are able to predict numerous properties of quantum systems with ...
Riccardo Molteni +2 more
doaj +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source