Results 101 to 110 of about 4,174,426 (295)

The CONEstrip Algorithm [PDF]

open access: yes, 2013
Uncertainty models such as sets of desirable gambles and (conditional) lower previsions can be represented as convex cones. Checking the consistency of and drawing inferences from such models requires solving feasibility and optimization problems. We consider finitely generated such models.
openaire   +2 more sources

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

open access: yesMolecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim   +3 more
wiley   +1 more source

BreastDCEDL: A standardized deep learning-ready breast DCE-MRI dataset of 2,070 patients

open access: yesScientific Data
Dynamic Contrast-Enhanced Magnetic Resonance Imaging (DCE-MRI) is essential for monitoring breast cancer treatment response, yet deep learning progress is limited by the lack of standardized, multi-center datasets. We present BreastDCEDL, a deep learning-
Naomi Fridman   +4 more
doaj   +1 more source

Self-stabilizing tree algorithms

open access: yes, 1995
Designers of distributed algorithms have to contend with the problem of making the algorithms tolerant to several forms of coordination loss, primarily faulty initialization. The processes in a distributed system do not share a global memory and can only
Thiagarajan, Visalakshi
core   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

open access: yesMolecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller   +10 more
wiley   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

open access: yesFEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz   +6 more
wiley   +1 more source

Three-layered semantic framework for public health intelligence

open access: yesJournal of Biomedical Semantics
Background Disease surveillance systems play a crucial role in monitoring and preventing infectious diseases. However, the current landscape, primarily focused on fragmented health data, poses challenges to contextual understanding and decision-making ...
Sathvik Guru Rao   +8 more
doaj   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

open access: yesFEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Spectral Quantum Chemistry and Infrared Resonance Library for Data-Driven Molecular Spectroscopy

open access: yesScientific Data
Infrared (IR) spectroscopy is a fundamental tool for molecular identification and characterization, yet comprehensive IR spectral databases remain limited, particularly for small organic molecules with well-defined theoretical baselines.
Anirudh Krishnadas   +3 more
doaj   +1 more source

Evaluating the Alzheimer's disease data landscape

open access: yesAlzheimer’s & Dementia: Translational Research & Clinical Interventions, 2020
Introduction Numerous studies have collected Alzheimer's disease (AD) cohort data sets. To achieve reproducible, robust results in data‐driven approaches, an evaluation of the present data landscape is vital.
Colin Birkenbihl   +8 more
doaj   +1 more source

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