Results 121 to 130 of about 2,582,277 (310)
Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA
FEBS Open Bio, EarlyView.PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro +1 more
wiley +1 more source
Efficient Algorithms to Globally Balance a Binary Search Tree
, 1984 A binary search tree can be globally balanced by readjustment of pointers or with a sorting process in O(n) time, n being the total number of nodes.
H. Chang, S. Iyengar
core
Approximation Algorithms for Network Design and Orienteering [PDF]
, 2010 Item withdrawn by Mark Zulauf (zulauf@illinois.edu) on 2010-07-16T16:48:21Z Item was in collections: University of Illinois Theses & Dissertations (ID: 1) No.
Korula, Nitish J.
core
Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA
FEBS Open Bio, EarlyView.Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley +1 more source
Towards Understanding First Order Algorithms for Nonconvex Optimization in Machine Learning
, 2019 Presented on February 11, 2019 at 11:00 a.m. as part of the ARC12 Distinguished Lecture in the Klaus Advanced Computing Building, Room 1116.Tuo Zhao is an assistant professor in the H.
Zhao, Tuo
core
Algorithms for space partitioning under constraints on geolocated attributes
, 2022 reservedThe present thesis work aims to study the problem of space partitioning under some constraints on geolacated attributes through the development and evaluation of specific ...
ROSSI, EDDIE
core
FEBS Open Bio, EarlyView.Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty +13 more
wiley +1 more source
Llamol: a dynamic multi-conditional generative transformer for de novo molecular design
Journal of CheminformaticsGenerative models have demonstrated substantial promise in Natural Language Processing (NLP) and have found application in designing molecules, as seen in General Pretrained Transformer (GPT) models.
Niklas Dobberstein +2 more
doaj +1 more source
, 2002 Summary: Classical statistical learning theory studies the generalisation performance of machine learning algorithms rather indirectly. One of the main detours is that algorithms are studied in terms of the hypothesis class that they draw their hypotheses from. In this paper, motivated by the luckiness framework of Shawe-Taylor et al.
Herbrich, Ralf, Williamson, Robert
openaire +4 more sources
Dual native G‐quadruplex folding is associated with chromatin looping at the MYC locus
FEBS Open Bio, EarlyView.BG4‐detectable G‐quadruplex (G4) in HaCaT and NHEK keratinocytes identified folded and unfolded G4s enriched at promoters/TSSs and active enhancers, whereas unfolded G4s also overlapped weak/poised enhancers. At MYC–PVT1, 3C‐qPCR detected enhancer–promoter looping only when G4s were simultaneously folded at both regulatory elements under native ...
Dieila Giomo de Lima +7 more
wiley +1 more source