Results 131 to 140 of about 2,582,277 (310)

Comparative assessment of crystallographic and cryo‐EM models in the Protein Data Bank

FEBS Open Bio, EarlyView.
Raw data obtained by X‐ray crystallography or cryo‐EM result in experimental maps, ultimately fitted by atomic models. Although the physical principles are different, the final results can be viewed, compared, and evaluated in the same way. With cryogenic electron microscopy (cryo‐EM) on track to surpass X‐ray crystallography as the preferred method ...
Alexander Wlodawer, Pawel Rubach, Zbigniew Dauter, Wojciech Dec, Dariusz Brzezinski, Marta Kulik, Wladek Minor, Mariusz Jaskolski   +7 more
wiley   +1 more source

Evaluating language model embeddings for Parkinson’s disease cohort harmonization using a novel manually curated variable mapping schema

Scientific Reports
Data Harmonization is an important yet time-consuming process. With the recent popularity of applications using Language Models (LMs) due to their high capabilities in text understanding, we investigated whether LMs could facilitate data harmonization ...
Yasamin Salimi, Tim Adams, Mehmet Can Ay, Helena Balabin, Marc Jacobs, Martin Hofmann-Apitius   +5 more
doaj   +1 more source

Drawings of complete multipartite graphs up to triangle flips

Journal of Computational Geometry
For a drawing of a labeled graph, the rotation of a vertex or crossing is the cyclic order of its incident edges, represented by the labels of their other endpoints. The extended rotation system (ERS) of the drawing is the collection of the rotations of
Oswin Aichholzer, Man-Kwun Chiu, Hung P. Hoang, Michael Hoffmann, Jan Kynčl, Yannic Maus, Birgit Vogtenhuber, Alexandra Weinberger   +7 more
doaj   +1 more source

Structural and biochemical insights into the thermostable esterase Ta0887 from Thermoplasma acidophilum

FEBS Open Bio, EarlyView.
In this study, a novel esterase from the thermoacidophilic archaeon Thermoplasma acidophilum was biochemically and structurally characterized. Our results demonstrate that Ta0887 is a highly thermostable esterase that preferentially hydrolyzes p‐nitrophenyl hexanoate and possesses an α‐helical cap domain that likely contributes to its substrate ...
Alejandro Delgado‐Rey, Miriam Livier Llamas‐García, Gabriela M. Montero‐Morán, Leticia Santos, Samuel Lara‐González   +4 more
wiley   +1 more source

Understanding and Mitigating the Risk of Accelerated Biological Aging in Survivors of Cancer: A Scoping Review

Aging and Cancer, EarlyView.
Cancer treatment is associated with measurable acceleration of biological aging across epigenetic, telomere, senescence, and immune biomarkers. However, biomarker validation and interventional strategies remain limited, especially in hematologic malignancies, underscoring the need for standardized multi‐omic aging assessments and adequately powered ...
Moataz Ellithi, Emily Herdman, Danielle Westmark, Vijaya R. Bhatt   +3 more
wiley   +1 more source

Algorithmic Neutrality

Australasian Journal of Philosophy
Algorithms wield increasing power over our lives. They can and often do wield that power unfairly, and much has been said about algorithmic fairness. In contrast, algorithmic neutrality has been largely neglected. I investigate algorithmic neutrality, asking: What is it? Is it possible? And what is its normative significance?
openaire   +2 more sources

RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu, Xin Duan, Fatemeh Peymani, Jia Wang, Chengjia Bao, Chaolong Xu, Ying Zou, Zixuan Zhang, Yunxi Zhang, Tongyue Li, Martin Pavlov, Junling Wang, Minhan Song, Tianyu Song, Xiaodi Han, Mingxi Sun, Danmin Shen, Ruoyu Duan, Huafang Jiang, Manting Xu, Holger Prokisch, Fang Fang   +21 more
wiley   +1 more source

Non-orientable AdS3 and its holography

Journal of High Energy Physics
Known solutions to three-dimensional gravity with negative cosmological constant consist of either AdS3 or its orbifolds (or orientifolds). We geometrically derive a novel non-orientable AdS3 spacetime that is an orientifold of a spinor double cover of ...
Shivesh Pathak, Lucas Kocia Kovalsky
doaj   +1 more source

High‐Resolution MRI Revealed Different Etiology‐Specific Associations With Cerebral Infarction in Adult Moyamoya Vasculopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective High‐resolution MRI enables detailed assessment of intracranial vessel wall pathology in moyamoya vasculopathy. We aimed to classify adult moyamoya vasculopathy etiologies using high‐resolution MRI and to examine subtype‐specific associations between high‐resolution MRI features and ischemic infarction.
Guangsong Han, Jiachun Pan, Yuehui Hong, Xiaoyuan Fan, Ming Yao, Lixin Zhou, Yicheng Zhu, Feng Feng, Jun Ni   +8 more
wiley   +1 more source

Estimating the causal impact of non-pharmaceutical interventions on COVID-19 spread in seven EU countries via machine learning

Scientific Reports
During the COVID-19 pandemic, Non-Pharmaceutical Interventions (NPIs) were imposed all over Europe with the intent to reduce infection spread. However, reports on the effectiveness of those measures across different European countries are inconclusive up
Jannis Guski, Jonas Botz, Holger Fröhlich   +2 more
doaj   +1 more source