Results 121 to 130 of about 5,408,588 (346)

BMI‐1 modulation and trafficking during M phase in diffuse intrinsic pontine glioma

FEBS Open Bio, EarlyView.
The schematic illustrates BMI‐1 phosphorylation during M phase, which triggers its translocation from the nucleus to the cytoplasm. In cycling cells, BMI‐1 functions within the PRC1 complex to mediate H2A K119 monoubiquitination. Following PTC596‐induced M phase arrest, phosphorylated BMI‐1 dissociates from PRC1 and is exported to the cytoplasm via its
Banlanjo Umaru, Deepak Kumar Mishra, Shiva Senthil Kumar, Hao‐Han Pang, Brendan Devine, Komal Khan, Rachid Drissi   +6 more
wiley   +1 more source

Llamol: a dynamic multi-conditional generative transformer for de novo molecular design

Journal of Cheminformatics
Generative models have demonstrated substantial promise in Natural Language Processing (NLP) and have found application in designing molecules, as seen in General Pretrained Transformer (GPT) models.
Niklas Dobberstein, Astrid Maass, Jan Hamaekers   +2 more
doaj   +1 more source

Algorithmic Luckiness

, 2002
Summary: Classical statistical learning theory studies the generalisation performance of machine learning algorithms rather indirectly. One of the main detours is that algorithms are studied in terms of the hypothesis class that they draw their hypotheses from. In this paper, motivated by the luckiness framework of Shawe-Taylor et al.
Herbrich, Ralf, Williamson, Robert
openaire   +2 more sources

Applicability of mitotic figure counting by deep learning: a development and pan‐cancer validation study

FEBS Open Bio, EarlyView.
In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes, Maria X. Isaksen, Frida Julbø, Manohar Pradhan, Andreas Kleppe, Sepp De Raedt, Ole‐Johan Skrede, Turid Torheim, John Arne Nesheim, Hans Martin Mohn, Hanne A. Askautrud, Karolina Cyll, Wanja Kildal, Emma Rewcastle, Melinda Lillesand, Vebjørn Kvikstad, Emiel Janssen, Robert Jones, Odd Terje Brustugun, Bjørn Brennhovd, Erik Skaaheim Haug, Lill‐Tove Rasmussen Busund, Elin Richardsen, Sigve Andersen, Tom Dønnem, Kristina Lindemann, Gunnar Kristensen, Neil A. Shepherd, Marco Novelli, Knut Liestøl, David Kerr, Håvard E. Danielsen, Tarjei S. Hveem   +32 more
wiley   +1 more source

Low complexity algorithms in knot theory [PDF]

, 2018
Olga Kharlampovich, Alina Vdovina
openalex   +1 more source

Algorithmic Recourse in Partially and Fully Confounded Settings Through\n Bounding Counterfactual Effects [PDF]

, 2021
Julius von Kügelgen, Nikita Agarwal, Jakob Zeitler, Afsaneh Mastouri, Bernhard Schölkopf   +4 more
openalex   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Evaluating language model embeddings for Parkinson’s disease cohort harmonization using a novel manually curated variable mapping schema

Scientific Reports
Data Harmonization is an important yet time-consuming process. With the recent popularity of applications using Language Models (LMs) due to their high capabilities in text understanding, we investigated whether LMs could facilitate data harmonization ...
Yasamin Salimi, Tim Adams, Mehmet Can Ay, Helena Balabin, Marc Jacobs, Martin Hofmann-Apitius   +5 more
doaj   +1 more source

On Convergence of some Gradient-based Temporal-Differences Algorithms for Off-Policy Learning [PDF]

, 2017
Huizhen Yu
openalex   +1 more source

Algorithm Blues [PDF]

Development and Change, 2020
openaire   +2 more sources