Results 101 to 110 of about 1,305,670 (283)

Matrix: Basic Concepts And Practical Applications In Daily Life

Jurnal Ilmiah Informatika dan Komputer
Matrix, as a fundamental mathematical concept, have crucial applications in computer science. This study analyzes: the basic structure of matrices (definition, types, addition-multiplication-inverse operations), and their implementation in computational ...
Muhamad Dimas Aprijal, Diny Syarifah
doaj   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Interactive communication between the user and the computer-aided design system of shaft forging on presses

MATEC Web of Conferences, 2018
Despite the accelerated development of computer technology, programming languages and methods in recent years, computer-aided design of open-die forging on presses is still not widespread due to weak formalization of the subject area.
Kanyukov Sergey, Konovalov Anatoly, Muizemnek Olga   +2 more
doaj   +1 more source

Algorithm Optimization and Performance Enhancement in Computer Science

Frontiers in Computing and Intelligent Systems
In the broad field of computer science, algorithm optimization is regarded as the cornerstone of improving system performance. With the rapid development of science and technology, the requirements for data processing and computing efficiency are increasing, and the optimization design of algorithms becomes critical.
openaire   +1 more source

DEVELOPMENT OF INTELLIGENT TUTORING SYTEMS: ALGORITHMS IN COMPUTER SCIENCE EDUCATION

, 2020
Learning algorithm design is difficult for novice computer science students. Most first-year CS classes are large and lecturers are often unable to provide individualized instructions to the struggling students. This is a prototype Intelligent tutoring system for teaching algorithm design.
openaire   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

METHODICAL ASPECTS OF SYSTEM MAXIMA IN LEARNING PROCESS OF OPERATIONS RESEARCH

Ìнформаційні технології в освіті, 2016
Training of operations research of bachelors of Computer Science is particularly important because combines both fundamental concepts and principles of mathematics and informational different disciplines and applied models and algorithms for their use ...
Taras Kobylnyk, Ulyana Kogut
doaj  

Network Localization of Fatigue in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Fatigue is among the most common symptoms and one of the main factors determining the quality of life in multiple sclerosis (MS). However, the neurobiological mechanisms underlying fatigue are not fully understood. Here we studied lesion locations and their connections in individuals with MS, aiming to identify brain networks ...
Olli Likitalo, Jaakko Kungshamn, Albert Bellmunt‐Gil, Silvia Tommasin, Abhineet Ojha, Matias Viitala, Juho Aaltonen, Jyrki Lötjönen, Juha Koikkalainen, Pauli Ylikotila, Patrizia Pantano, Merja Soilu‐Hänninen, Juho Joutsa   +12 more
wiley   +1 more source

Frailty Exacerbates Disability in Progressive Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background To evaluate frailty in severe progressive multiple sclerosis (PMS) and to investigate the underlying mechanisms. Methods This prospective, cross‐sectional, multicenter study enrolled a late severe PMS group requiring skilled nursing (n = 53) and an age, sex, and disease duration‐matched control PMS group (n = 53).
Taylor R. Wicks, Anna Wolska, Diala Ghazal, Dejan Jakimovski, Bianca Weinstock‐Guttman, Alexander Burnham, Niels Bergsland, Michael G. Dwyer, Alan T. Remaley, Robert Zivadinov, Murali Ramanathan   +10 more
wiley   +1 more source