Results 111 to 120 of about 18,990 (308)

Decoding Spatial Heterogeneity and Multi‐Omics Regulation with Hierarchical Graph Learning

Advanced Science, EarlyView.
ABSTRACT Recent advances in spatial multi‐omics technologies have enabled the simultaneous profiling of multiple molecular layers within the same tissue slice, providing unprecedented opportunities to investigate tissue spatial organization. However, most existing computational methods identify spatial domains in a purely data‐driven manner, rarely ...
Jiazhou Chen, Jiahui Xie, Yi Liao, Junyu Li, Longqi Liu, Xin Gao, Hongmin Cai   +6 more
wiley   +1 more source

Computation of infix probabilities for probabilistic context-free grammars [PDF]

, 2011
The notion of infix probability has been introduced in the literature as a generalization of the notion of prefix (or initial substring) probability, motivated by applications in speech recognition and word error correction.
Satta, Giorgio, Mark-jan Nederhof, NEDERHOF M. J, Giorgio Satta, Nederhof, Mark Jan   +4 more
core  

Derandomizing from Random Strings [PDF]

, 2010
In this paper we show that BPP is truth-table reducible to the set of Kolmogorov random strings R(K). It was previously known that PSPACE, and hence BPP is Turing-reducible to R(K).
Loff Barreto, B. S. (Bruno Serra), Koucký, M., Koucký, M. (Michal), Lance Fortnow, Buhrman, H.M. (Harry), Loff Barreto, Bruno Serra, Bruno Loff, Loff, B., Koucký, Michal, Fortnow, L. (Lance), Buhrman, Harry, Michal Koucký, Harry Buhrman, Fortnow, L., Fortnow, Lance, Buhrman, H.   +15 more
core   +1 more source

A Bone Marrow–Mimetic Hydrogel Enables Dual‐Phase Hemostasis and Vascularized Osteogenesis for Cranial Defects

Advanced Science, EarlyView.
A biomimetic, fiber‐reinforced hydrogel (FE‐PDA@Fib/Gel‐TG) that enables dual‐phase cranial defect repair. The system provides: instant hemostasis in the early stage, and sustained co‐delivery of pro‐angiogenic and osteogenic signals for synergistic vascularized bone regeneration.
Lingbin Che, Donghong Li, Huan Zhang, Tingting Xu, Juhan Li, Xuanzhou Chen, Louis D. Zhang, Shuguang Wang, Dianwen Song, Dongyong Sha   +9 more
wiley   +1 more source

Targeting PLD3 Reverses the Immunosuppressive Niche by Reprogramming Tumor‐Associated Macrophages and Potentiates Antitumor Immunity

Advanced Science, EarlyView.
PLD3 activates the lysosomal‐AKT‐NF‐κB axis to drive cellular senescence in macrophages, establishing an immunosuppressive TME by limiting the infiltration of cytotoxic T, NK, and NKT cells, which confers resistance to anti‐PD‐1 therapy. Abrine inhibits PLD3 expression, restoring antitumor immunity and synergizing with anti‐PD‐1 treatment.
Xingtu Qin, Qiong Li, Xuemei Xu, Yuhan Wu, Yin Zhu, Jieqiong Wu, Yuan Fang, Qiubei Chen, Shuyang Wang, Jiang Yu, Yaping Ye, Hongli Jiao   +11 more
wiley   +1 more source

Nash equilibria, gale strings, and perfect matchings [PDF]

, 2011
This thesis concerns the problem 2-NASH of finding a Nash equilibrium of a bimatrix game, for the special class of so-called “hard-to-solve” bimatrix games.
Merschen, Julian
core  

Charge and reduce: A fixed-parameter algorithm for String-to-String Correction

Discrete Optimization, 2011
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Faisal N. Abu-Khzam, Henning Fernau, Michael A. Langston, Serena Lee-Cultura, Ulrike Stege   +4 more
openaire   +2 more sources

SSR4 sustains Tertiary Lymphoid Structures by Regulation Quality Control of N‐linked Glycosylation During B‐cell Differentiation Into Plasmacyte in Colorectal Cancer

Advanced Science, EarlyView.
SSR4, a TRAP component induced in B cells, governs BAFFR N‐glycosylation via DDOST to sustain NF‐κB signaling, B‐cell differentiation, and TLS maturation. Its loss impairs anti‐tumor immunity, while overexpression improves antibody glycosylation and ADCC, revealing a critical regulator for cancer immunotherapy.
Wei Zhao, Youcai Zhao, Haiyang Li, Bowen Yang, Siyan Lu, Xueting Fu, Caixia Zhang, Yirong Chen, Xiaofeng Bian, Xinghua Ma, Xiaobing Yang, Bin Wang, Yuan Fang, Lulu Yang, Yelin Zhao, Shuli Zhao   +15 more
wiley   +1 more source

Energy Efficient Hardware Accelerators for Packet Classification and String Matching [PDF]

, 2010
This thesis focuses on the design of new algorithms and energy efficient high throughput hardware accelerators that implement packet classification and fixed string matching.
Kennedy, Alan
core  

How Advanced Artificial Intelligence Technologies Shape Drug–Drug and Drug–Target Interaction Modeling

Advanced Science, EarlyView.
This review explores the convergence of artificial intelligence technologies in modeling drug–drug and drug–target interactions. By evaluating advanced feature engineering, architectural innovations, and learning paradigms reveals shared evolutionary trends and critical challenges, such as cold‐start settings and shortcut learning.
Xin Sun, Tong Wang
wiley   +1 more source