Results 81 to 90 of about 1,546,431 (297)

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Aligner: Efficient Alignment by Learning to Correct

Advances in Neural Information Processing Systems 37
With the rapid development of large language models (LLMs) and ever-evolving practical requirements, finding an efficient and effective alignment method has never been more critical. However, the tension between the complexity of current alignment methods and the need for rapid iteration in deployment scenarios necessitates the development of a model ...
Jiaming Ji, Boyuan Chen 0008, Hantao Lou, Donghai Hong, Borong Zhang, Xuehai Pan, Tianyi Qiu, Juntao Dai, Yaodong Yang 0001   +8 more
openaire   +3 more sources

Report to the Governor from the Mental Health Alignment Workgroup: executive summary

, 2001
This archived document is maintained by the Oregon State Library as part of the Oregon Documents Depository Program. It is for informational purposes and may not be suitable for legal purposes.Title from PDF title page (viewed on May 7, 2009)At head of ...

core  

Developing a model for alignment between individual and organizational performance management and organizational objectives

Journal of Human Resource Management, 2018
The success of each organization depends on its ability to evaluate its performance and then use the results of performance evaluation to enhance its efficiency. The present study is aimed at developing a model for investigating the relationships between
Shapoor Sherafat, Ahmad Ali Khaef Elahi
doaj  

Lateral closing wedge high‐tibial osteotomy is a long‐lasting option for patients under the age of 55 with medial compartment osteoarthritis

Journal of Experimental Orthopaedics
Purpose Assess the survival of the closing wedge high tibial osteotomy (CWHTO) with failure defined as progression to total knee arthroplasty (TKA) and perioperative complications.
Ahmed Mahmoud, Bashirr Garba, Tim McMeniman, Brett Collins, Peter McMeniman, Peter Myers   +5 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Optimalisasi Media Praktik Alignment

, 2016
Dalam optimalisasi media praktik alignment ini menggunakan metodologi perancangan dimana sistemnya melalui beberapa tahap yaitu studi literatur indentifikasi masalah perancangan evaluasi rancangan proses manufaktur perakitan dan uji coba.
Musfikar, Dian Safitri, Riksan Hamid, Nurmayanti   +3 more
core  

Question Word Intonation in Tashlhiyt Berber: Is ‘high’ good enough?

Laboratory Phonology, 2017
The present study investigates the intonational marking of question words (qwords) in Tashlhiyt Berber. The first part of the study identifies a number of possible prosodic patterns on qwords as employed in conversational contexts.
Anna Bruggeman
doaj   +2 more sources

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source