Results 81 to 90 of about 4,843 (156)
Alirocumab in Pediatric Patients With Heterozygous Familial Hypercholesterolemia
International audienceImportance Many pediatric patients with heterozygous familial hypercholesterolemia (HeFH) cannot reach recommended low-density lipoprotein cholesterol (LDL-C) concentrations on statins alone and require adjunct lipid-lowering ...Manvelian, Garen, Daniels, Stephen, Caprio, Sonia, Averna, Maurizio, Garon, Genevieve, Cariou, Bertrand, Scemama, Michel, Poulouin, Yann, Santos, Raul, D, Wiegman, Albert +9 morecore +1 more sourceEffects of Alirocumab on Cardiovascular Events After Coronary Bypass Surgery
, 2019 BACKGROUND Patients with acute coronary syndrome (ACS) and history of coronary artery bypass grafting (CABG) are at high risk for recurrent cardiovascular events and death.OBJECTIVES This study sought to determine the clinical benefit of adding ...Chumburidze, Vakhtang, Toma, Mustafa, Ahuad Guerrero, Rodolfo A., Marcus, Jill, DeVore, Adam D., Markov, Dimitar T., Morisset, Anne, Dong, Yugang, Alexander, John H., Perkins, Lynn, Codutti, Oscar R., Letierce, Alexia, Rossi, Paulo R. F., Ritt, Luiz Eduardo F., Midzic, Zlatko, Garrahy, Paul J., Vrolix, Mathias C. M., Jure, Horacio O., Collins, Nicholas, Sousa, Luciano, Novotny, Vojtech, Araneda, Guillermo, Sujjavanich, Darin, Shi, Xubo, Muslibegovic, Adis, Pecin, Ivan, Kristensen, Kjeld S., Durak-Nalbantic, Azra, Motovska, Zuzana, Mansourati, Jacques, Precoma, Dalton B., Nielsen, Peter Kaiser, Sassone, Sonia A., Bang, Lia E., Ramos Lopez, Gabriel Arturo, Xu, Biao, Zhou, Yujie, Dorsel, Thomas, Erglis, Andrejs, Pearce, Stephen, Striekwold, Harry, Jatin, Fernando G. Manzur, Li, Huanming, Colombo, Hugo R., Flores, Romulo E. Oqueli, Sabbah, Eric, Kalil, Renato, Hameed, Adnan, Schmidt, Ekkehard, Soots, Mai, Dong, Shaohong, Montenegro Valdovinos, Pablo Carlos, Machado, Leandro, Fong, Peter, Alves De Lima, Alberto E., Lopes, Renato D., Aboyans, Victor, Horowitz, John, Fazlibegovic, Emir, Vejar, Margarita, Zheng, Yang, Hrabar, Adrian D., Lin, Wenhua, Zweiker, Robert, Duda, Norberto, Probst, Vincent, Cestari, Horacio G., Jones, William Schuyler, Schwartz, Gregory G., Silva, Pedro G. M. de B., Pincetti, Cristian, Yusoff, Khalid, Nicolau, Jose C., Fell, David, de Souza, Juliana A., Dimov, Bojidar I., Ristic, Arsen D., Edelberg, Jay M., Olivares, Claudia, Gislason, Gunnar, Wollaert, Bart, Xu, Xiping, Fernandez, Angela M., Bono, Julio O. E., Colquhoun, David, Hove, Jens D., Lai, Christopher, Zeiher, Andreas M., Yan, Andrew Tze-Kay, Vidotti, Maria H., Bata, Iqbal, Davidsen, Flemming, Pagava, Zurab, Raffo, Carlos A., Steg, Philippe Gabriel, Lominadze, Zaza, Todorov, Georgi V., Zhao, Xingsheng, Arstall, Margaret A., Cools, Frank, De Salazar, Dora I. Molina, Herazo, Aristides Sotomayor, Lopez-Jaramillo, Patricio, Karpov, Yuri, Sherwood, Matthew W., Correa Flores, Roger M., Vizel, Saul, Patel, Chetan B., Marusincova, Ivana, Ghlonti, Ramaz, Leclercq, Florence, Huber, Kurt, Yu, Yihua, Rogers, James F., Cleveland, David, Stratmann, Matthias, Lianopoulos, Emmanouil, Silva, Ricardo P., Harrington, Robert A., Zong, Wenxia, Hii, Chris L. S., Valgimigli, Marco, Hemetsberger, Rayyan, Guo, Ying, Zahger, Doron, Marx, Nikolaus, Li, Jianping, Mendoza, Jose L. Accini, Dorobantu, Maria, Ruiz, Ricardo L. Fernandez, Paterlini, Gustavo A., Luo, Zhurong, Lillis, Linda, Lin, Jinxiu, Zhang, Zheng, Armaganijan, Luciana, Ostadal, Petr, Hlatky, Mark A., Vervoort, Geert, Moriarty, Patrick M., Gosselin, Gilbert, Brennan, J. Matthew, Cui, Lan, Silveira, Jose A., Su, Xi, Laucevicius, Aleksandras, Gomez Vilamajo, Oscar A., Hermans, Kurt, Meloni, Chiara, Vahula, Veiko, Yang, Xiangjun, Beauloye, Christophe, Halvorsen, Sigrun, Botelho, Roberto V., Higuera, Juan Diego, van Diepen, Sean F. P., Giorgeto, Flavio E., Chen, Dandan, Qu, Baiming, Reis, Gilmar, Guneri, Sema, Chen, Yundai, Huidobro, Laura, Zheng, Zeqi, Wang, Jingfeng, Pesant, Yves, Szarek, Michael, Dombrowski, Keith, Kim, Sang-Hyun, Mincheva, Valentina M., Pojskic, Belma, Leung, Raymond, Shaburishvili, Tamaz, Lehman, Sam J., Berger, Rudolf, Kichukov, Kostadin N., Parkhomenko, Alexander, Leaes, Paulo E., Rodes-Cabau, Josep, Wei, Meng, Walichiewicz, Piotr Maria, Wang, Jian'An, Juonala, Markus, Fu, Guosheng, Delarche, Nicolas, Pirenne, Bruno, Vogel, Robert, Huang, Shi'An, Maron, David J., Ge, Junbo, Budaj, Andrzej, Zaidman, Cesar J., Sritara, Piyamitr, Starmer, Gregory, Steg, Ph Gabriel, Souza, Weimar K. S. B., Montana, Oscar R., Jiang, Weihong, Kolls, Bradley J., Larsen, John, Endsley, Patricia, Heinc, Petr, Schiele, Francois, Vallejos, Julio A., Perez, Luis, Eppinger, Arleen, Liberman, Alberto, Feitosa, Gilson S., Pordy, Robert, Clifton, Shaun, Kedev, Sasko, Caime, Guillermo D., Martsin, Kaja, Bagai, Akshay, Sy, Rody G., Drexel, Heinz, Roberts-Thomson, Philip, Feng, Yi, Davies, Richard, Patocchi, Cristian A., Fadlallah, Hussein, Johansen, Peter Betton, Cheng, Xiaoshu, Xu, Dingli, Spinar, Jindrich, de Silva, H. Asita, Terzic, Ibrahim, Lepage, Serge, Vallejo, Gregorio Sanchez, Kormann, Adrian, Jeppesen, Jorgen, Pimentel Filho, Pedro, Alings, Marco, Hess, Connie Ng, Klausen, Ib C., Ding, Chunhua, Sinnaeve, Peter, Kong, David F., Abrantes, Jose Antonio M., Taskinen, Marja-Riitta, Garrido, Marcelo, MacDonald, Paul, Yuan, Zuyi, Xavier, Denis, Kiviniemi, Tuomas, Knowles, Joshua W., Castadot, Marc, Bonfanti, Alberto J. Cadena, Blumberg, Eduardo D. S., Cerqueira, Maria Jose A. G., Nigro, Frank, Chen, Jiyan, Sijbrands, Eric J. G., Cartasegna, Luis R., Dion, Danielle, Soopold, sllar, Garcia Brasca, Daniela F., Wang, Jianzhong, Cha, James, Frost, Lars, Michaud, Nicolas, Dalby, Anthony J., Neuenschwander, Fernando, Lopez, Gabriel Arturo Ramos, Yanez, Mario, Stone, James, Tunon, Jose, Wilson, Matthew D., Rauch-Kroehnert, Ursula, Hanotin, Corinne, Lazov, Petar V., Mathews, Robin, Chaitman, Bernard, Kaucak, Vladimir, Nielsen, Tonny, Hoppe, Uta, Simoons, Maarten L., Mehta, Rajendra H., Morais, Joao, Liu, Shaowen, Lefevre, Thierry, Mackinnon, Ignacio J., Bordonava, Anselmo P., Amuchastegui, Marcos, Costa, Fernando, Gotcheva, Nina N., Silva, Sandra I. Barrera, Berland, Jacques, Omran, Heyder, Naplava, Robert, Clerc, Jerome, Puymirat, Etienne, Caccavo, Alberto, Kaiser, Sergio, Duronto, Ernesto A., Paganelli, Franck, Aguirre, Arnoldo, Bahit, Maria Cecilia, Medrano Allende, Juan C., Podpera, Ivo, Taurio, Jyrki, Eliaschewitz, Freddy G., Coufal, Zdenek, Jukema, J. Wouter, Goodman, Shaun G., Stasek, Josef, Zizka, Jiri, Shah, Bimal R., Barone-Rochette, Gilles, Rosenson, Robert, Huang, Weijian, Schmidberg, Jorge M., Botia, Diana C. Luna, Ray, Kausik K., Hagstrom, Emil, Moryusef, Angele, White, Harvey D., Shaw, James, Lorenzatti, Alberto J., Yao, Zhuhua, Bittner, Vera A., Vico, Marisa L., Lopez, Rodrigo Botero, Luquez, Hugo A., Li, Ying, Arroyo, Julian A. Coronel, Raev, Dimitar H., Bustamante Labarta, Miguel H., Mehta, Shamir, Huikuri, Heikki, Vikman, Saila, Kim, Hyo Soo, Angel Hominal, Miguel, Nani, Sebastian, Li, Xiaodong, Waisman, Gabriel D., Michalaros, Yorghos L., Coste, Pierre, Roe, Matthew T., Khintibidze, Irakli, Su, Guohai, Bhatt, Deepak L., Diaz, Ariel, Ducas, John, Novaretto, Leonardo P., Nikolov, Fedya P., Olsson, Anders G., Kiss, Robert Gabor, Danchin, Nicolas, Liberopoulos, Evangelos, Alvarisqueta, Andres F., Sun, Yuemin, Tumbev, Haralin S., Dilic, Mirza, Kuchar, Jiri, Belhassane, Abdelkader, Berli, Mario A., Hoffer, Etienne, Barakovic, Fahir, Khabeishvili, George, Ilieva-Pandeva, Katya A., Kouz, Simon, Fang, Weiyi, Moura Jorge, Jose C., Ivanova, Raya, Luciardi, Hector L., de Santos, Mayler O. N., Horak, David, Nogareda, Gustavo, Airaksinen, Juhani K., Soggia, Ana Priscila, Posio, Pirjo, Prieto, Juan-Carlos, Lin, Xuefeng, Zhang, Xuelian, Montalescot, Gilles, Guzman, Pablo N., Tse, Hung-Fat, Weidinger, Franz, Hoag, Gordon, Roosen, John, Pandey, Amritanshu, Lozada, Henry J. Garcia, Deloatch, Shalonda, Mentz, Robert J., Hedman, Anu, Coverdale, Steven G. M., Ke, Yuannan, Robinson, Simon, May, Ole, Rouleau, Jean-Lucien, Shehova-Yankova, Nina S., Sussex, Bruce, Sader, Mark, Saavedra, Silvia S., Povolny, Petr, Morel, Olivier, Kaikkonen, Kari, Yang, Xinchun, Reiner, Zeljko, Faes, Dirk, Triana, Miguel A. Urina, Savard, Daniel, Shou, Xiling, Porthan, Kimmo, Florenzano, Fernando, Parada, Jeffrey Castellanos, Ferrari, Emile, Potthoff, Sergio, Appel, Karl-Friedrich, Acevedo, Monica, Schiavi, Lilia B., Waites, Jonathon H., Caruso, Orlando C., Benov, Haralambi O., Yong, Huo, Senaratne, Manohara, Ducrocq, Gregory, Marin Neto, Jose A., Lomholdt, Jens D., Vijayaraghavan, Ram, Hald, Flemming, Dujardin, Karl, Raungaard, Bent, Murin, Jan, Machova, Vilma, Giuliano, Maria E., Jaramillo, Nicolas, Chua, Terrance, Novoa, Federico, Stellbrink, Christoph, Kornder, Jan, Huang, Lan, Varleta, Paola, Fernandez, Mauricio, Alan, David, Bottcher, Morten, Dran, Ricardo D., Soward, Allan, Zhu, Hong, Clemmensen, Peter, Dickey, Sheila, Pereira, Sabrina Bernardez, Leonardi, Sergio, Fras, Zlatko, Tzekova, Maria L., Jordan, Joseph Dedrick, Rech, Rafael, Muller, Christian, Eapen, Zubin, Fernandes Manenti, Euler Roberto F., Boccara, Franck, Kelsey, Sheryl F., Petranov, Stanislav L., Viigimaa, Margus, Cottin, Yves, Dupuis, Robert, Rokyta, Richard, Nieminen, Markku S., Barbato, Emanuele, Garcia Duran, Ruben O., Aidar Ayoub, Jose Carlos, Leone, Attilio, Velcheva, Elena S., Peng, Daoquan, Bodanese, Luiz C., Linhart, Ales, Claeys, Marc, Giordano, Jorge A., Bourgeois, Ronald, Raffel, Owen, De Wolf, Luc, Convens, Carl, Poulsen, Steen Hvitfeldt, Huynh, Thao, Reis, Helder J. L., Stringfellow, Kenya, Trotter, Charlene, Vulic, Dusko, Diaz, Rafael, Carnero, Gabriela S., Maia, Lilia Nigro, Povsic, Thomas J., Carroll, Patrick A., Vuurmans, Tycho, Adamkova, Vera, Alexander, Karen, Bai, Feng, Saporito, Wladimir, Moreira, Humberto Graner, Aylward, Philip E., Mollov, Mihail N., Videbaek, Lars, Kimura, Takeshi, Svab, Premysl, Chiang, Chern-En +495 morecore +2 more sourcesThe roles of apo(a) size, phenotype, and dominance pattern in PCSK9-inhibition-induced reduction in Lp(a) with alirocumab[S]
Journal of Lipid Research, 2017 An elevated level of lipoprotein (a) [Lp(a)] is a risk factor for CVD. Alirocumab, a monoclonal antibody to proprotein convertase subtilisin/kexin type 9, is reported to reduce Lp(a) levels.Byambaa Enkhmaa, Erdembileg Anuurad, Wei Zhang, Kun Yue, Ching-Shang Li, Lars Berglund +5 moredoaj +1 more sourceAlirocumab inhibits atherosclerosis, improves the plaque morphology, and enhances the effects of a statin
, 2014 Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibition is a potential novel strategy for treatment of CVD. Alirocumab is a fully human PCSK9 monoclonal antibody in phase 3 clinical development.Hoek, A.M. van den, Jukema, J.W., Kühnast, S., Pieterman, E.J., Peyman, A., Sasiela, W.J., Gusarova, V., Schäfer, H.L., Schwahn, U., Princen, H.M.G., Hoorn, J.W.A. van der +10 morecore Relationship between alirocumab, PCSK9, and LDL-C levels in four phase 3 ODYSSEY trials using 75 and 150 mg doses [PDF]
, 2019 BACKGROUND: Alirocumab is a monoclonal antibody to proprotein convertase subtilisin/kexin type 9 (PCSK9). OBJECTIVE: Changes in PCSK9, alirocumab, and low-density lipoprotein cholesterol (LDL-C) levels were assessed after treatment with alirocumab at ...DiCioccio, A Thomas, DiCioccio, A. Thomas, Cannon, Christopher P., Robinson, Jennifer G., Roth, Eli M., Cannon, Christopher P, Roth, Eli M, Colhoun, Helen M, Baccara-Dinet, Marie T., Baccara-Dinet, Marie T, Colhoun, Helen M., Pordy, Robert, Farnier, Michel, Taskinen, Marja-Riitta, Robinson, Jennifer G, Brunet, Aurelie, Lecorps, Guillaume, Kastelein, John J P, Kastelein, John J. P. +18 morecore +1 more sourceEffect of PCSK9 Inhibition With Alirocumab in Patients With Probable Familial Hypercholesterolemia or Type III Hyperlipoproteinemia: Results From the ODYSSEY OUTCOMES Trial
Journal of the American Heart Association: Cardiovascular and Cerebrovascular DiseaseBackground In this post hoc analysis of the ODYSSEY OUTCOMES (Evaluation of Cardiovascular Outcomes After an Acute Coronary Syndrome During Treatment With Alirocumab) trial, we evaluated the efficacy of alirocumab in patients with probable heterozygous ...Gregory P. Geba, Kusha A. Mohammadi, Amy Damask, Charles Paulding, Luca A. Lotta, George Hindy, Robert Pordy, Garen Manvelian, Michael D. Shapiro, Vera A. Bittner, Deepak L. Bhatt, Michael Szarek, Gregory G. Schwartz, Ph. Gabriel Steg, Sergio Fazio +14 moredoaj +1 more source
