Results 21 to 30 of about 21,558 (210)

Molecular basis of antibiotic sensing by the TetR family regulator CecR – a structural perspective

open access: yesThe FEBS Journal, EarlyView.
Escherichia coli CecR, a member of the TetR family regulators, senses selected antibiotics and activates the expression of a putative drug efflux pump. Although present in many pathogenic Enterobacteriales strains, CecR remains poorly characterized. We present the first CecR crystal structure, which reveals a unique tunnel‐like ligand‐binding cavity ...
Agnieszka J. Pietrzyk‐Brzezinska   +5 more
wiley   +1 more source

Selección fenotípica de árboles plus de tres especies forestales maderables en poblaciones naturales en el Distrito de Molinopampa (Amazonas)

open access: yesRevista de Investigación en Agroproducción Sustentable, 2017
El estudio se realizó en el distrito de Molinopampa en el departamento de Amazonas, cuyo objetivo fue seleccionar Árboles Plus de las especies maderables de “aliso” Alnus acuminata, “cedro” Cedrela odorata e “ishpingo” Ocotea sp.
Mario Oliva, Ysaías Rimachi
doaj   +1 more source

Space‐based remote imaging spectroscopy of the Aliso Canyon CH4 superemitter [PDF]

open access: yesGeophysical Research Letters, 2016
AbstractThe Aliso Canyon gas storage facility near Porter Ranch, California, produced a large accidental CH4 release from October 2015 to February 2016. The Hyperion imaging spectrometer on board the EO‐1 satellite successfully detected this event, achieving the first orbital attribution of CH4 to a single anthropogenic superemitter.
D. R. Thompson   +9 more
openaire   +5 more sources

GATA3 Deletion Associated With Juvenile Idiopathic Arthritis: Expanding the Phenotypic Spectrum of Hypoparathyroidism, Sensorineural Deafness, and Renal Dysplasia (HDR) Syndrome

open access: yesAmerican Journal of Medical Genetics Part A, Volume 200, Issue 3, Page 733-737, March 2026.
ABSTRACT Hypoparathyroidism, sensorineural deafness, and renal dysplasia (HDR) syndrome is caused by pathogenic variants in the GATA3 gene located on chromosome 10p14. Here we present a 10‐year‐old girl with HDR syndrome who also has oligoarticular juvenile idiopathic arthritis (JIA).
Lauren N. Meiss   +8 more
wiley   +1 more source

Human FASTK preferentially binds single‐stranded and G‐rich RNA

open access: yesThe FEBS Journal, Volume 293, Issue 3, Page 729-748, February 2026.
Although FASTK is known to play a role in mRNA biology, the mechanism through which it recognizes RNA has yet to be unraveled. Here, we used purified human FASTK to characterize its RNA‐binding properties in vitro. We found that FASTK prefers ssRNA oligonucleotides containing guanines with the potential to form G‐quadruplexes and binds robustly to any ...
Daria M. Dawidziak   +7 more
wiley   +1 more source

High-Resolution Genomic Profiling of Chromosomal Abnormalities in Human Stem Cells Using the 135 K StemArray

open access: yesStem Cells International, 2012
Culturing stem cells for an extended period of time can lead to acquired chromosomal aberrations. Determining the copy number variant (CNV) profile of stem cell lines is critical since CNVs can have dramatic effects on gene expression and tumorigenic ...
Aaron M. Elliott   +2 more
doaj   +1 more source

Screening-Level Safety Assessment of Personal Care Product Constituents Using Publicly Available Data

open access: yesCosmetics, 2018
Organizations recommend evaluating individual ingredients when assessing the safety of personal care or cosmetic products. The goal of this study was to present a screening-level safety assessment methodology to evaluate the safety of a product by ...
Ernest S. Fung   +7 more
doaj   +1 more source

Syntheses and Structures of Water‐Soluble Model Complexes Related to the Active Site of Molybdenum and Tungsten‐Dependent Oxidoreductases

open access: yesZeitschrift für anorganische und allgemeine Chemie, Volume 652, Issue 1, January 6, 2026.
Complex salts with potassium counter cations and bisdithiolene oxido molybdate or tungstate anions are water tolerant and soluble in purely aqueous medium. Four different synthetic routes to water‐soluble complexes of the type K2[MOx(dt)2] (M = Mo, W; dt = ene‐1,2‐dithiolate, x = 1, 2) applicable to different ligand precursors are presented.
Sebastian Pätsch   +6 more
wiley   +1 more source

Associations among particulate matter, hazardous air pollutants and methane emissions from the Aliso Canyon natural gas storage facility during the 2015 blowout

open access: yesEnvironment International, 2019
In October of 2015, a large underground storage well at the Aliso Canyon natural gas storage facility experienced a massive methane leak (also referred to as “natural gas blowout”), which resulted in the largest ever anthropogenic release of methane from
Diane A. Garcia-Gonzales   +6 more
doaj   +1 more source

Structural insights into how vacuolar sorting receptor recognizes the C‐terminal sorting determinant of a vicilin‐like seed storage protein

open access: yesThe FEBS Journal, Volume 293, Issue 1, Page 257-270, January 2026.
Soluble cargo proteins are sorted to the vacuoles via a receptor‐mediated mechanism. Combining crystallographic and mutagenesis studies, we showed how the C‐terminal sorting determinant (ctVSD) of vicilin‐like seed storage protein VL22 is recognized by the protease‐associated domain of Arabidopsis vacuolar‐sorting receptor 1.
Shu Nga Lui   +4 more
wiley   +1 more source

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