Results 21 to 30 of about 207,130 (329)

Prognostic Impact of Baseline Liver Metastasis in ALK Fusion-Positive Metastatic Lung Cancer: A Retrospective Review

South Asian Journal of Cancer, 2022
Akhil Kapoor Introduction The prognosis of anaplastic lymphoma kinase (ALK) fusion-positive metastatic non-small cell lung cancer (mNSCLC) patients has improved drastically since the introduction of targeted
Satvik Khaddar, Akhil Kapoor, Vanita Noronha, Vijay M. Patil, Nandini Menon, Abhishek Mahajan, Amit Janu, Rajiv Kumar, Nilendu Purandare, Kumar Prabhash   +9 more
doaj   +1 more source

Detection of ALK fusion transcripts in FFPE lung cancer samples by NanoString technology [PDF]

, 2017
Background: ALK-rearranged lung cancers exhibit specific pathologic and clinical features and are responsive to anti-ALK therapies. Therefore, the detection of ALK-rearrangement is fundamental for personalized lung cancer therapy. Recently, new molecular
A Cesano, Adriana Cruvinel Carloni, Adriane F. Evangelista, AP Becker, AS Crystal, AT Shaw, Cristovam Scapulatempo-Neto, DR Camidge, DW-S Wong, EL Kwak, EM Gaughan, FH Wilson, Flávia E. de Paula, I Dagogo-Jack, Iberê Cauduro Soares, J Wu, JM Heuckmann, Jose Elias Miziara, JS Reis-Filho, K McKeage, K Rikova, K Takeuchi, LS Yamane, M Soda, Maicon F. Zanon, Maressa Ferreira-Neto, Mariana Andozia Morini, ME Lira, MM Kulkarni, MW Wynes, Pedro de Marchi, R Roskoski, Rui M. Reis, S-H Jung, SM Ali, SW Morris, T-M Rogers, YP Mossé   +37 more
core   +2 more sources

The impact of perennial allergic rhinitis with/without allergic asthma on sleep, work and activity level

Allergy, Asthma & Clinical Immunology, 2019
Background Allergic respiratory diseases such as allergic rhinitis (AR) and allergic asthma (AA) are common conditions that can influence sleep and daytime functioning. However, the significance of this impact is unclear—particularly in perennial allergy
Mercedes Rodriguez Romano, Stephanie James, Emily Farrington, Richard Perry, Lisa Elliott   +4 more
doaj   +1 more source

F-18 FDG PET/CT characterization and predictive efficacy for driver mutation positive and negative pulmonary adenocarcinoma in correlation with clinico-pathologic data

National Board of Examinations Journal of Medical Sciences, 2023
Background: Fluorine-18 (isotope)-Fluoro-deoxyglucose positron emission tomography computed tomography (F-18-FDG PET/CT) as a non-invasive method could predict driver mutation status in pulmonary adenocarcinoma.
Ashish Acharya K, Shelley Simon, Indirani M   +2 more
doaj   +1 more source

Discovery of 3,5-Diamino-1,2,4-triazole Ureas as Potent Anaplastic Lymphoma Kinase Inhibitors [PDF]

, 2011
A series of novel 3,5-diamino-1,2,4-triazole benzyl ureas was identified as having potent anaplastic lymphoma kinase (ALK) inhibition exemplified by 15a, 20a, and 23a, which exhibited antiproliferative IC50 values of 70, 40, and 20 nM in Tel-ALK ...
Deng, Xianming, George, Rani E., Gray, Nathanael Schiander, Jänne, Pasi A., Kim, Nam Doo, Luther, William, Sasaki, Takaaki, Sim, Taebo, Wang, Jinhua, Zhang, Jianming   +9 more
core   +2 more sources

Delivery options for sublingual immunotherapy for allergic rhinoconjunctivitis: clinical considerations for North America [PDF]

Rhinology Online, 2022
Background: Sublingual immunotherapy (SLIT) can be delivered via tablets (SLIT-T) or aqueous drops (SLIT-D). SLIT-D dosing recommendations using North American extracts were published in 2015.
Kent Lam, Jayant M. Pinto, Stella E. Lee, Karen Rance, Hendrik Nolte   +4 more
doaj   +1 more source

Resonance reliability and importance measure analysis of multi-span pipe conveying fluid embedded in temperature-varying matrix

Xibei Gongye Daxue Xuebao, 2021
Pipe system conveying fluid faces the problem of multi-order resonance failure caused by broadband excitation. For solving above problem, the dynamic stiffness method is employed to solve the dynamic equations of multi-span pipes considering the ...
WU Nan, GUO Qing, TONG Guojun, LIU Yongshou   +3 more
doaj   +1 more source

The Effect of Cement Dust on the Activity of GOT , GPT and ALK Enzymes in Al-Qaim Cement Factory Workers [PDF]

مجلة جامعة الانبار للعلوم الصرفة, 2012
This research was conducted on a random sample of (58) individuals , (38) of them were directly exposed to cement dust . They were distributed according to units into (9) in oven department , (17) individuals in cement grinding department and (12) in ...
Ziad Khazer Abdul Razaaq, Haitham Latef Abd, Mustafa Nuhad Jumaa   +2 more
doaj   +1 more source

Research Progress of Proteolysis Targeting Chimeria in NSCLC Therapy

Chinese Journal of Lung Cancer, 2022
Proteolysis targeting chimeria (PROTAC) degrades target proteins by utilizing the ubiquitin-proteasome pathway, subverting the concept of traditional small molecule inhibitors.
Lin JIANG, Jingbo ZHANG, Jiaqi HU, Haixiang QI, Heng XU   +4 more
doaj   +1 more source

Intra-Seasonal Initiation of the SQ-Standardised Grass Allergy Immunotherapy Tablet Routinely Applied by Allergy Specialists and General Practitioners with Experience in Treatment of Allergy: A Non-Interventional Observational Study

Pulmonary Therapy, 2018
Introduction Intra-seasonal start of treatment with the SQ® grass sublingual immunotherapy(SLIT) tablet (GRAZAX®, ALK, Denmark) has been previously demonstrated to be well-tolerated. The objective of our study was to investigate the tolerability of intra-
Jan-Alexander Schwab, Hendrik Wolf, Jörg Schnitker, Eike Wüstenberg   +3 more
doaj   +1 more source