Results 31 to 40 of about 96,322 (259)

How does conformational flexibility influence key structural features involved in activation of anaplastic lymphoma kinase? [PDF]

, 2014
Anaplastic Lymphoma Kinase (ALK) plays a major role in developing tumor processes and therefore has emerged as a validated therapeutic target. Applying atomistic molecular dynamics simulations on the wild type enzyme and the nine most frequently ...
Lee, Christian, Donev, Rossen, Christov, Christo, Black, Gary, Karabencheva-Christova, Tatyana   +4 more
core   +1 more source

A brief report on the mutational landscape in non-small cell lung cancer of South Asian patients: Comparison at a US and an Indian Institution

Lung India, 2022
Background: Various molecular underpinnings of lung cancer have been noted in Asian populations, especially with targetable oncogenic drivers such as EGFR mutations and ALK rearrangements, although they have been lesser described in South Asian/Indian ...
Mohana Roy, Amanjit Bal, Nalini Gupta, Kuruswamy T Prasad, Heather A Wakelee, Navneet Singh   +5 more
doaj   +1 more source

Non-small-cell lung cancer: how to manage ALK-, ROS1- and NTRK-rearranged disease

Drugs in Context, 2022
Oncogene addiction in non-small-cell lung cancer (NSCLC) has profound diagnostic and therapeutic implications. ALK, ROS1 and NTRK rearrangements are found in about 2–7%, 1–2% and 0.2% of unselected NSCLC samples, respectively; however, their frequency is
Daniele Marinelli, Marco Siringo, Giulio Metro, Biagio Ricciuti, Alain J Gelibter   +4 more
doaj   +1 more source

BiolDentification of Alk-associated signaling complexes

, 2022
Anaplastic lymphoma kinase (Alk) is a receptor tyrosine kinase (RTK) of the insulin receptor family. Alterations in human ALK signaling have been implicated in multiple malignancies including pediatric neuroblastoma.
Uçkun, Ezgi
core   +1 more source

Intra-Seasonal Initiation of the SQ-Standardised Grass Allergy Immunotherapy Tablet Routinely Applied by Allergy Specialists and General Practitioners with Experience in Treatment of Allergy: A Non-Interventional Observational Study

Pulmonary Therapy, 2018
Introduction Intra-seasonal start of treatment with the SQ® grass sublingual immunotherapy(SLIT) tablet (GRAZAX®, ALK, Denmark) has been previously demonstrated to be well-tolerated. The objective of our study was to investigate the tolerability of intra-
Jan-Alexander Schwab, Hendrik Wolf, Jörg Schnitker, Eike Wüstenberg   +3 more
doaj   +1 more source

Characteristics, quality of life and control of respiratory allergic diseases caused by house dust mites (HDMs) in Spain: a cross-sectional study

Clinical and Translational Allergy, 2019
This multicentre, cross-sectional study conducted in Spain assessed the clinical characteristics and quality of life of patients who were aged 14–55 years and had allergic rhinitis and/or asthma, which was due to house dust mite sensitisation, for at ...
Beristain Ana, Fernando de la Torre, the EpidMite Study Group   +2 more
doaj   +1 more source

Identification and characterization of peripheral T-cell lymphoma-associated SEREX antigens. [PDF]

, 2011
Peripheral T-cell lymphomas (PTCL) are generally less common and pursue a more aggressive clinical course than B-cell lymphomas, with the T-cell phenotype itself being a poor prognostic factor in adult non-Hodgkin lymphoma (NHL).
Graham P. Collins, Liggins, Amanda P., Liggins, AP, Lawrie, Charles H., Banham, Alison H., Pulford, Karen, Pulford Karen, Christopher D. O. Cooper, Cooper Christopher D. O., Christian S. R. Hatton, Hatton, Christian S.R., Cooper, CD, Hatton Christian S. R., Lawrie, CH, Liggins Amanda P., Banham, Alison, Christopher D O Cooper, Hatton, CS, Banham, AH, Collins, GP, Charles H Lawrie, Pulford, K, Amanda P Liggins, Banham Alison H., Karen Pulford, Charles H. Lawrie, Amanda P. Liggins, Collins Graham P., Graham P Collins, Collins, Graham P., Alison H Banham, Christian S R Hatton, Lawrie Charles H., Cooper, Christopher D.O., Alison H. Banham   +34 more
core   +2 more sources

Opportunities and challenges of circulating biomarkers in neuroblastoma [PDF]

Open Biology, 2019
Molecular analysis of nucleic acid and protein biomarkers is becoming increasingly common in paediatric oncology for diagnosis, risk stratification and molecularly targeted therapeutics. However, many current and emerging biomarkers are based on analysis
Ricky M. Trigg, Jacqui A. Shaw, Suzanne D. Turner   +2 more
doaj   +1 more source

Targeting ALK in Neuroendocrine Tumors of the Lung. [PDF]

, 2022
Background Anaplastic lymphoma kinase (ALK) rearrangements are known oncogenic drivers in non-small cell lung cancer (NSCLC). Few case reports described the occurrence of such rearrangements in large cell neuroendocrine carcinomas (LCNECs) of the lung
Kiessling, Michael K, Akhoundova, Dilara, Curioni-Fontecedro, Alessandra, Höller, Sylvia, Fritsch, Ralph, Rüschoff, Jan H, Rechsteiner, Markus, Kiessling, Michael K., Rüschoff, Jan H., Haberecker, Martina   +9 more
core   +2 more sources

Ultra-deep mutational analysis of NPM-ALK and possible implications on target therapy in anaplastic large cell lymphoma of childhood [PDF]

, 2013
Anaplastic Large Cell Lymphoma (ALCL) represents a distinct subset of aggressive T-cell non-Hodgkin lymphoma (NHL) accounting for about 3% of adult NHL and 10 to 15% of childhood lymphomas.
Lovisa, Federica
core