Results 41 to 50 of about 96,322 (259)

Central Nervous System Tumors Among Infants in Canada: A Report From CYP‐C

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Central nervous system (CNS) tumors in infants are rare, pose unique clinical challenges, and lack large‐scale evidence‐based data to guide management. This study seeks to describe CNS tumors in Canadian infants and to compare their outcomes with those of older children.
Samuel Sassine, Hallie Coltin, Sylvia Cheng, Lucie Lafay‐Cousin, Vanan Issai Magimairajan, Craig Erker, Stéphanie Vairy, Lynette Bowes, Adam Fleming, Donna Johnston, Sarah McKillop, Roona Sinha, Julie Bennett, Christina Coleman, Laura Wheaton, Shayna Zelcer, Samuele Renzi, Thai Hoa Tran   +17 more
wiley   +1 more source

Physiological Changes and alk Gene Instability in Pseudomonas oleovorans during Induction and Expression of alk Genes [PDF]

, 1996
The alk genes of Pseudomonas oleovorans, which is able to metabolize alkanes and alkenes, are organized in alkST and alkBFGHJKL clusters, in which the expression of alkBFGHJKL is positively regulated by AlkS.
Witholt, Bernard, Witholt, Bernard,, Janssen, Dick B., Dick B. Janssen, Chen, Qi, Chen, Qi,, Qi Chen, Bernard Witholt, Janssen, Dick B.,   +8 more
core   +1 more source

Comparative Drug Response Profiling in Neuroblastoma Cell Lines and Patient‐Derived Tumor Organoids

Pediatric Blood &Cancer, EarlyView.
ABSTRACT High‐risk neuroblastoma remains a leading cause of pediatric cancer mortality, and improved preclinical models are needed to guide therapeutic developments. We screened seven high‐risk neuroblastoma cell lines and three patient‐derived tumor organoids with 528 compounds alongside bone marrow controls, and compared them with external datasets ...
Krzysztof Wierbiłowicz, Se Whee Sammy Park, Aironas Los, Ernest Liu, Nona Struyf, Tom Erkers, Sören Lehmann, Jan J. Molenaar, Jakob Stenman, Olli Kallioniemi, Päivi Östling, Brinton Seashore‐Ludlow, Kasper Karlsson   +12 more
wiley   +1 more source

Transformationspotential von NPM-ALK, p21SNFT und Tax in Reifen T Lymphozyten [PDF]

, 2010
To date it is not clear at which stage of differentiation mature T cell leukaemia/lymphoma is initiated. Previous studies in our group showed that mature T cells are relatively resistant to transformation.
Kumar, Ashok
core  

Primary ALK-1-negative anaplastic large cell lymphoma of the brain: Case report and review of the literature [PDF]

, 2009
Anaplastic large cell lymphoma (ALCL) is a type of non-Hodgkin lymphoma composed of CD30-positive cells. Anaplastic lymphoma kinase (ALK) -1 positive ALCL frequently involves both lymph nodes and extranodal sites.
Kodama, Kunihiko, Kawaguchi, Kenji, Hokama, Masanobu, Hongo, Kazuhiro, Tanaka, Yuichiro   +4 more
core   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Global variations of IgE cross-reactivity in Cupressus allergy

Journal of Allergy and Clinical Immunology: Global
Background: Seasonal allergic rhinitis triggered by Cupressaceae species is a significant concern worldwide, particularly in regions such as Japan, China, Spain, and the United States.
Takeru Sugawara, MSc, Tingting Ma, MD, Xueyan Wang, MD, Neera Chakrapani, PhD, Hiroki Matsuhara, BSc, Danying Peng, MSc, Carlos Blanco, MD, PhD, Domingo Barber, PhD, Kathrine Beck Sylvestersen, PhD, Edward G. Brooks, MD, Peter Sejer Andersen, PhD, Katsuyo Ohashi-Doi, PhD, Jens Emil Vang Petersen, PhD   +12 more
doaj   +1 more source

Praca na własny rachunek a ochrona w zakresie zbiorowego prawa pracy

Acta Universitatis Lodziensis Folia Iuridica, 2022
W wyniku nowelizacji ustawy o związkach zawodowych, która weszła w życie 1 stycznia 2019 r., osoby świadczące pracę na własny rachunek spełniające kryteria wskazane w art. 11 pkt 1 ustawy o związkach zawodowych zostały wyposażone w szersze prawo koalicji
Monika Latos-Miłkowska
doaj   +1 more source

IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo

FEBS Open Bio, EarlyView.
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley   +1 more source

Identification of the primary sensitizing mite (dominant mite) in patients with allergic respiratory disease sensitized to Dermatophagoides pteronyssinus and Lepidoglyphus destructor

World Allergy Organization Journal
Objective: To identify the dominant mite in patients with allergic respiratory disease (ARD) and double sensitization to Dermatophagoides pteronyssinus (Dpt) and Lepidoglyphus destructor (Ld).
José Arias-Irigoyen, MD, Irene Arias-Talavera, MD, Manuel Lombardero, PhD, Agustín Galán, BSc, Rafael I. Monsalve, PhD   +4 more
doaj   +1 more source