Results 31 to 40 of about 207,130 (329)

Characteristics, quality of life and control of respiratory allergic diseases caused by house dust mites (HDMs) in Spain: a cross-sectional study

Clinical and Translational Allergy, 2019
This multicentre, cross-sectional study conducted in Spain assessed the clinical characteristics and quality of life of patients who were aged 14–55 years and had allergic rhinitis and/or asthma, which was due to house dust mite sensitisation, for at ...
Beristain Ana, Fernando de la Torre, the EpidMite Study Group   +2 more
doaj   +1 more source

ALK Mutations Conferring Differential Resistance to Structurally Diverse ALK Inhibitors [PDF]

Clinical Cancer Research, 2011
Abstract Purpose: EML4–ALK fusions define a subset of lung cancers that can be effectively treated with anaplastic lymphoma kinase (ALK) inhibitors. Unfortunately, the duration of response is heterogeneous and acquired resistance limits their ultimate efficacy. Thus, a better understanding of resistance mechanisms will help to enhance
Heuckmann, J., Hölzel, M., Sos, M., Heynck, S., Balke-Want, H., Koker, M., Peifer, M., Weiss, J., Lovly, C., Grütter, C., Rauh, D., Pao, W., Thomas, R.   +12 more
openaire   +3 more sources

Aggressive inflammatory myofibroblastic tumor of the tongue (clinical case)

Опухоли головы и шеи, 2020
The study objective is to present a rare clinical case of an aggressive myofibroblastic tumor of the tongue.Clinical case. A 24-year-old patient was revealed a 44 × 25 × 50 mm volumetric formation of the left side of the tongue spreading to the ...
A. P. Polyakov, A. V. Mordovsky, M. V. Ratushny, I. V. Rebrikova, O. V. Matorin, I. V. Reshetov   +5 more
doaj   +1 more source

A brief report on the mutational landscape in non-small cell lung cancer of South Asian patients: Comparison at a US and an Indian Institution

Lung India, 2022
Background: Various molecular underpinnings of lung cancer have been noted in Asian populations, especially with targetable oncogenic drivers such as EGFR mutations and ALK rearrangements, although they have been lesser described in South Asian/Indian ...
Mohana Roy, Amanjit Bal, Nalini Gupta, Kuruswamy T Prasad, Heather A Wakelee, Navneet Singh   +5 more
doaj   +1 more source

Molecular rationale for the use of PI3K/AKT/mTOR pathway inhibitors in combination with crizotinib in ALK-mutated neuroblastoma [PDF]

, 2014
Mutations in the ALK tyrosine kinase receptor gene represent important therapeutic targets in neuroblastoma, yet their clinical translation has been challenging.
Azarova, Anna M., Bhatnagar, Namrata, Chesler, Louis, Christie, Amanda L., Drake, Lauren E., Frumm, Stacey, George, Rani E., Gray, Nathanael S., Kung, Andrew L., Liu, Qinsong S., Moore, Nathan F., Ross, Kenneth N., Sanda, Takaomi, Stegmaier, Kimberly   +13 more
core   +3 more sources

ALK-positive large B-cell lymphomas with cryptic SEC31A-ALK and NPM1-ALK fusions

Haematologica, 2010
We report 2 ALK-positive large B-cell lymphoma cases showing granular cytoplasmic and cytoplasmic/nuclear ALK immunostaining in which cryptic ALK rearrangements were identified by fluorescent in situ hybridization and molecular analysis. In the first case, the ALK-involving t(2;3)(p23;q27) masked the cryptic SEC31A-ALK fusion generated by an insertion ...
Van Roosbroeck, Katrien, Cools, Jan, Dierickx, Daan, Thomas, José, Vandenberghe, Peter, Stul, Michel, Delabie, Jan, Peeters, Christiane, Marynen, Peter, Wlodarska, Iwona   +9 more
openaire   +4 more sources

ALK Inhibitor Response in Melanomas Expressing EML4-ALK Fusions and Alternate ALK Isoforms [PDF]

Molecular Cancer Therapeutics, 2018
Abstract Oncogenic ALK fusions occur in several types of cancer and can be effectively treated with ALK inhibitors; however, ALK fusions and treatment response have not been characterized in malignant melanomas. Recently, a novel isoform of ALK (ALKATI) was reported in 11% of melanomas but the response of melanomas expressing ALKATI ...
Kasey L, Couts, Judson, Bemis, Jacqueline A, Turner, Stacey M, Bagby, Danielle, Murphy, Jason, Christiansen, Jennifer D, Hintzsche, Anh, Le, Todd M, Pitts, Keith, Wells, Allison, Applegate, Carol, Amato, Pratik, Multani, Edna, Chow-Maneval, John J, Tentler, Yiqun G, Shellman, Matthew J, Rioth, Aik-Choon, Tan, Rene, Gonzalez, Theresa, Medina, Robert C, Doebele, William A, Robinson   +21 more
openaire   +2 more sources

Non-small-cell lung cancer: how to manage ALK-, ROS1- and NTRK-rearranged disease

Drugs in Context, 2022
Oncogene addiction in non-small-cell lung cancer (NSCLC) has profound diagnostic and therapeutic implications. ALK, ROS1 and NTRK rearrangements are found in about 2–7%, 1–2% and 0.2% of unselected NSCLC samples, respectively; however, their frequency is
Daniele Marinelli, Marco Siringo, Giulio Metro, Biagio Ricciuti, Alain J Gelibter   +4 more
doaj   +1 more source

Toward a general theory of linking invariants

, 2005
Let N_1, N_2, M be smooth manifolds with dim N_1 + dim N_2 +1 = dim M$ and let phi_i, for i=1,2, be smooth mappings of N_i to M with Im phi_1 and Im phi_2 disjoint.
Arnol’d, Arnol’d, Arnol’d, Chas, do Carmo, Gusarov, Kaiser, Low, Low, Rudyak, Stong, Switzer, Turaev, Turaev, Turaev, Vassiliev, Vladimir V Chernov, Voronov, Yuli B Rudyak   +18 more
core   +3 more sources

A novel patient-derived tumorgraft model with TRAF1-ALK anaplastic large-cell lymphoma translocation. [PDF]

, 2014
Although anaplastic large-cell lymphomas (ALCL) carrying anaplastic lymphoma kinase (ALK) have a relatively good prognosis, aggressive forms exist. We have identified a novel translocation, causing the fusion of the TRAF1 and ALK genes, in one patient ...
...], Abate, F., Abele, C., Acquaviva, A., Agostinelli, C., Aime, S., Aliberti, S., Barreca, A., Bertoni, F., Bessone, L., Boi, M., Cerchietti, L., Chan, W.C., Cheng, M., Crescenzo, R., Di Giacomo, F., Falini, B., Ficarra, E., Gaudiano, M., Inghirami, G., Iqbal, J., Kwee, I., Landra, I., Lasorsa, E., Longo, D.L., Machiorlatti, R., Messana, K., Novero, D., Pera-Gresely, B., Piccaluga, P.P., Pileri, S., Piva, R., Ponzoni, M., Rabadan, R., Rinaldi, A., Ruggeri, B., Shultz, L.D., Tabb\uf2, F., The European T-cell Lymphoma Study Group [..., Tiacci, E., Todaro, M., Tousseyn, T., Van Der Krogt, J.-A., Wlodarska, I.   +43 more
core   +1 more source