Results 71 to 80 of about 96,322 (259)

Growth Differentiation Factor 15 as a Cerebrospinal Fluid Biomarker for the Diagnosis and Prognosis of Leptomeningeal Metastasis

Annals of Neurology, EarlyView.
Objective As leptomeningeal metastasis (LM) has a poor prognosis, reliable cerebrospinal fluid (CSF) diagnostic biomarkers are urgently needed. This study evaluated the diagnostic value of CSF growth differentiation factor 15 (GDF15) in LM from lung adenocarcinoma (LUAD) and breast cancer (BC).
Haoyu Ruan, Jie Li, Fuhai Wang, Lei Zhang, Jie Luo, Yuan Mu, Ting Wang, Yuqing Wu, Jingping Liu, Yunyun Ning, Xuan Deng, Ming Guan, Jian Xu   +12 more
wiley   +1 more source

Die Aza‐Büchner–Curtius–Schlotterbeck‐Reaktion: Selektive Bildung Quartärer Kohlenstoffzentren

Angewandte Chemie, EarlyView.
Wir stellen die Aza‐Büchner–Curtius–Schlotterbeck‐(ABCS)‐Reaktion vor: eine milde, katalysatorfreie Methode zur Homologierung von Aryliminen. Im Gegensatz zum traditionellen BCS‐Mechanismus durchläuft das Diazo‐Intermediat eine selektive C─C‐Insertion zur Bildung eines quartären Zentrums.
Simon O. Angerer, Vincent George, Aryaman Pattanik, Gaia Carpentiero, Tereza Morcinková, Julia Rehbein, Burkhard König   +6 more
wiley   +1 more source

Real-World Shelf Life of Epinephrine Auto-Injectors in Canada: Implications for Renewal Frequency and Patient Burden

Journal of Market Access & Health Policy
Although patients in Canada at risk of anaphylaxis are recommended to maintain access to two in-date epinephrine auto-injectors (EAIs) at all times, underuse during emergencies remains common.
John Papastergiou, Mille Vang Lybech, Christoffer Mertz, Anne Danø, Jess Finney, David Grabowski   +5 more
doaj   +1 more source

Synthese von Aminocyclopropanen durch redoxneutrale Aminoalkylierung

Angewandte Chemie, EarlyView.
Wir berichten über eine Synthese von Aminocyclopropanen durch Hydroaminoalkylierung unter Einsatz kostengünstiger, leicht zugänglicher Ausgangsmaterialien. Der Ansatz bietet Orthogonalität zu gängigen Methoden und ermöglicht eine breite Toleranz gegenüber funktionellen Gruppen.
Gwyndaf A. Oliver, Konstantin Günther, Chiara Sebastianelli‐Schoditsch, Sophie Woolford, Iina Ludwig, Harald H. Sitte, Nuno Maulide   +6 more
wiley   +1 more source

ALK-Positive Histiocytosis with Peripheral Blood Histiocytes: A Case Report

, 2021
Histiocytoses are a diverse group of rare, clinically heterogeneous disorders characterised by tissue infiltration of histiocytes, which may result in organ dysfunction and failure.
Williams, Bronwyn, Barbaro, Pasquale, Swain, Fiona   +2 more
core   +1 more source

Plant‐Derived Silver Nanoparticles From Senegalia catechu: Antimicrobial Activity and Sunlight‐Driven Photocatalysis

Asia-Pacific Journal of Chemical Engineering, EarlyView.
ABSTRACT Silver nanoparticles (Ag NPs) have garnered attention for their environmental and medicinal potential, emphasizing the need for eco‐friendly synthesis. This study produces Ag NPs by reacting silver nitrate with aqueous Senegalia catechu leaf extract, a reductant and stabilizer.
Devendra Khadka, Suraksha Sharma, Janaki Baral, Milan Babu Poudel, Bhoj Raj Poudel, Bishnu Prasad Bastakoti, Megh Raj Pokhrel   +6 more
wiley   +1 more source

Ceritinib in the treatment of ALK-positive patients with nonsmall-cell lung cancer

Медицинский совет, 2019
Ceritinib is the second ALK tyrosine kinase inhibitor after crizotinib, registered in the Russian Federation for the treatment of ALKpositive patients with non-small cell lung cancer (NSCLC). Later alectinib was registered. Thus, we have the opportunity,
K. K. Laktionov, E. V. Reutova
doaj   +1 more source

Thermophilic anaerobic treatment and biogas generation from wastewater produced in an advanced biorefinery process

Biofuels, Bioproducts and Biorefining, EarlyView.
Abstract Anaerobic digestion can be an alternative method for treating wastewater from second‐generation biorefineries while simultaneously producing biogas. However, the feasibility of the process and key operational parameters by which wastewater produced in lignocellulosic biorefineries affects reactor performance remain poorly understood.
Jairo M. Carrillo‐Osorio, Germán Buitrón   +1 more
wiley   +1 more source

Efficacy, safety and cost‐effectiveness of CAR‐T therapy

British Journal of Clinical Pharmacology, EarlyView.
CAR T‐cells demonstrate high efficacy in blood cancers, including ALL, MM and DLBCL. Innovations target solid tumours despite challenges such as antigen escape. Combination therapies enhance the delivery and infiltration of CAR T cells. Toxicity, cost and resistance remain major barriers to clinical use.
Emina Karahmet Sher, Amina Džidić‐Krivić, Emma Pinjic, Nejra Selak, Kanita Omerbasic, Alexandar Chupin, Andrej Belancic, Almir Fajkic   +7 more
wiley   +1 more source

Modelling the impact of sublingual immunotherapy versus subcutaneous immunotherapy on patient travel time and CO2 emissions in Sweden

Scientific Reports
In Sweden, allergy immunotherapy (AIT) is available as either subcutaneous immunotherapy (SCIT) injections or sublingual immunotherapy (SLIT) tablets and is used to treat moderate-severe allergic rhinitis (AR).
Lars-Olaf Cardell, Thomas Sterner, Waqas Ahmed, Andreas Kallsoy Slættanes, Mikael Svärd, Richard F. Pollock   +5 more
doaj   +1 more source