Results 91 to 100 of about 96,322 (259)

Diagnose ALK transclocation in non small lung cancer patient

, 2017
A nem kis sejtes tüdődaganatok (non-small-cell lung cancers, NSCLC) 85%-át teszik ki az összes tüdődaganatnak. Az ALK- EML4 génátrendeződés az NSCLC 2–5%-ában mutatható ki, döntően adenocarcinoma szövettani típusban.
Nagy, Valéria
core  

Efficacy and Safety of Durvalumab and Tremelimumab in Metastatic Non‐Small Cell Lung Cancer: A Systematic Review and Meta‐Analysis of Randomized Controlled Trials

Chronic Diseases and Translational Medicine, EarlyView.
PRISMA 2020 flow diagram of included studies. ABSTRACT Purpose Immune checkpoint inhibitors have transformed treatment strategies for metastatic non‐small cell lung cancer (mNSCLC). This study aimed to assess the efficacy and safety of durvalumab combined with tremelimumab compared with those of standard chemotherapy, particularly in patients with low ...
Ikhwan Rinaldi, Eric Ricardo Yonatan, Tasia Esterita   +2 more
wiley   +1 more source

Current approaches to treatments for schizophrenia spectrum disorders, part I: an overview and medical treatments

Neuropsychiatric Disease and Treatment, 2013
Wai Tong Chien, Annie LK Yip School of Nursing, Faculty of Health and Social Sciences, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong Abstract: During the last three decades, an increasing understanding of the etiology ...
Chien WT, Yip ALK
doaj  

Role of Quality of Life in Daily Functioning, Communication with Care Teams, and Treatment Decisions in Patients with ALK+ NSCLC

JTO Clinical and Research Reports
Introduction: This study investigated quality of life (QoL) and its role in treatment decision making among patients with anaplastic lymphoma kinase (ALK)+ NSCLC.
Heather Law, MA, Huamao M. Lin, PhD, Eileen Curran, PhD, Annette Szumski, MS, Jacinta Wiens, PhD, Jennifer Blender, PhD, Emily S. Venanzi, PhD, Erin L. Schenk, MD, PhD, Jessica J. Lin, MD, Jennifer C. King, PhD   +9 more
doaj   +1 more source

The Prognosis of Advanced Non-Small Cell Lung Cancer Patients with Precision-Targeted Therapy Guided by NGS Testing or Routine Testing

Cancer Management and Research, 2023
Tingting Tu,1,2,* Dandan Chen,1,2,* Houjun Jiang,1,2,* Jianhua Ma,1,2 Hongwei Wang,1,2 Cheng Chen1,2 1Department of Radiotherapy, Lianyungang Clinical Institute, Jiangsu University (The Second People’s Hospital of Lianyungang), Lianyungang ...
Tu T, Chen D, Jiang H, Ma J, Wang H, Chen C   +5 more
doaj  

ALK-positive large B-cell lymphomas with cryptic SEC31A-ALK and NPM1-ALK fusions [PDF]

, 2010
We report 2 ALK-positive large B-cell lymphoma cases showing granular cytoplasmic and cytoplasmic/nuclear ALK immunostaining in which cryptic ALK rearrangements were identified by fluorescent in situ hybridization and molecular analysis.
Delabie, Jan, Wlodarska, Iwona, Peeters, Christiane, Cools, Jan, Dierickx, Daan, Thomas, José, Stul, Michel, Vandenberghe, Peter, Van Roosbroeck, Katrien, Marynen, Peter   +9 more
core   +1 more source

Toward Fit‐for‐Purpose Data for Drug Assessment in Non‐small Cell Lung Cancer: A Core Dataset

Clinical Pharmacology &Therapeutics, EarlyView.
Considering the high unmet medical need in people with non‐small cell lung cancer (NSCLC), the drug assessment for targeted therapies often rely on small populations and single‐arm trials, challenging the evaluation by regulatory authorities, health technology assessment bodies (HTAb), and clinicians.
Geeske F. Grit, Maaike van Dartel, Laura Rodwell, Hanneke van der Woude, Cornelis Boersma, Peter G. M. Mol, Doranne Hilarius   +6 more
wiley   +1 more source

Association between PD-L1 expression with EGFR, ALK, and ROS1 driver oncogene mutations in non-small cell lung cancer

Indian Journal of Pathology and Microbiology
Background: Driver mutations and immunological expressions have gained importance in recent years for targeted therapies and immunotherapies of nonsmall cell lung cancer (NSCLC). Aims: This study examined the association between PD-L1 expression and ALK,
Dülger Onur, Yaylım İlhan, Öz Büge
doaj   +1 more source

Un nouveau rôle de la tyrosine kinase oncogénique NPM-ALK dans le contrôle de l'expression génique au niveau post-trancriptionnel [PDF]

, 2011
La protéine hybride à activité tyrosine kinase, NPM-ALK est exprimée dans 75% des Lymphomes Anaplasiques à Grandes Cellules (LAGC). Bien que le phénotype tumoral de ces lymphomes soit en partie associé à l'activation constitutive de nombreuses voies de ...
Bergalet, Julie
core  

Utility of Fine Needle Aspiration Supernatant for Real‐Time PCR–Based Mutation Analysis in Non–Small Cell Lung Cancer

Diagnostic Cytopathology, EarlyView.
ABSTRACT Background The emergence of personalized therapy and molecular sequencing has significantly transformed the management of advanced non–small cell lung carcinoma (NSCLC). Supernatants obtained from fine needle aspiration (FNA) have been shown to be a reliable source of high‐quality nucleic acid for molecular testing.
Adeyinka Akinsanya, Riley Gorden, Madison Rector, Hamna Muhammad, Melissa Randolph, Matt Sperling, Kemin Xu, Sheila Segura, Omer Saeed, Tieying Hou   +9 more
wiley   +1 more source