Results 101 to 110 of about 96,322 (259)
Novel therapeutic and diagnostic approaches to EML4-ALK-driven cancers
EML4-ALK drives progression of ~5% of non-small cell lung cancers and multiple EML4-ALK variants exist as a result of alternative EML4 breakpoints. Of these, V3 is correlated with the most aggressive disease and increased metastasis in patients however ...
Savvas Papageorgiou (13308312)
core +1 more source
Synthetic Strategies for the Construction of Cyclobutane‐Fused Heterocycles
European Journal of Organic Chemistry, EarlyView.Cyclobutane‐fused heterocycles are important motifs commonly present in bioactive compounds, recognized for their rigid 3D structures that confer unique properties. However, synthesizing these compounds remains challenging. This review discusses current methods for their synthesis, such as photochemical, metal‐catalyzed, and Lewis acid‐mediated [2 + 2]
Michela Vargiu +2 more
wiley +1 more source
Chelation‐Assisted Metal‐Catalyzed Ligation and Cleavage Reactions for Chemical Biology
European Journal of Organic Chemistry, EarlyView.Chelation‐assisted transition metal catalysis has emerged as a promising complement to bioorthogonal click chemistry for studying biological processes. By pre‐organizing catalytic metal centers, designed coordinating substrates enhance reactivity and biocompatibility, enabling site‐selective ligation and decaging reactions in complex biological media ...
Emilie Plantiveau +3 more
wiley +1 more source
Harnessing Diversity: Majority‐Group Acculturation Predicts Creativity and Flourishing Over Time
European Journal of Social Psychology, EarlyView.ABSTRACT Creativity and flourishing are core aims of higher education (HE) institutions and government initiatives globally. Large‐scale projects have linked creativity and flourishing with cultural diversity, yet their associations with majority‐group acculturation (i.e., how members of dominant culture groups adopt minority‐cultural elements and/or ...
David Colledge +9 more
wiley +1 more source
New treatment options for ALK+ advanced non-small-cell lung cancer: critical appraisal of ceritinib [PDF]
, 2016 Sacha I Rothschild Department of Internal Medicine, Medical Oncology, University Hospital Basel, Basel, Switzerland Abstract: Rearrangements in ALK gene and EML4 gene were first described in 2007.
Rothschild SI
core
Inherited metabolic epilepsies–established diseases, new approaches
Epilepsia Open, EarlyView.Abstract Inherited metabolic epilepsies (IMEs) represent the inherited metabolic disorders (IMDs) in which epilepsy is a prevailing component, often determining other neurodevelopmental outcomes associated with the disorder. The different metabolic pathways affected by individual IMEs are the basis of their rarity and heterogeneity.
Itay Tokatly Latzer, Phillip L. Pearl
wiley +1 more source
Targeted inhibition in tumors with ALK dependency
, 2013 Eunice L Kwak, Jeffrey W Clark, Alice T ShawMassachusetts General Hospital Cancer Center, Boston, MA, USAAbstract: The oncogenic function of gene translocations involving the anaplastic lymphoma kinase (ALK) was first reported in rare subtypes of non ...
Clark JW, Shaw AT, Kwak EL
core
Identification of a novel inherited ALK variant M1199L in the WNT type of medulloblastoma
, 2016 Rearrangements involving the ALK gene were identified in a variety of cancers, including paediatric tumour neuroblastoma where presence of ALK expression is also associated with adverse prognosis.
Maria Łastowska +7 more
core +1 more source
iMeta, EarlyView.The Human Biomarker Navigator integrates the disease continuum, biomarker dynamics, cross‐organ biomarker networks, biomarker classification, and technology‐driven paradigms. It maps how biomarkers link multi‐system physiology and pathology across the nervous, respiratory, endocrine, circulatory, immune, digestive, urinary, reproductive, and ...
Meng‐Yao Li +29 more
wiley +1 more source
ALK-rearranged lung adenocarcinoma without EML4-ALK and KIF5B-ALK.
, 2012 Panel A shows the results of anti-ALK immunohistochemistry with the iAEP method on pulmonary adenocarcinoma in situ, nonmucinous. The staining pattern was diffusely cytoplasmic.
Manabu Soda (184596) +8 more
core +1 more source