Results 191 to 200 of about 321,976 (264)

Quantitative Systems Toxicology Model Predicts Obeticholic Acid‐Associated Liver Injury in Metabolic Dysfunction‐Associated Steatotic Liver Disease

Clinical Pharmacology &Therapeutics, EarlyView.
Obeticholic acid (OCA), a synthetic analog of chenodeoxycholic acid, was approved in 2016 for the treatment of primary biliary cholangitis. Early clinical trials revealed elevated liver biomarkers in healthy subjects receiving supratherapeutic OCA doses (100–250 mg).
Abigail K. Mayo, James J. Beaudoin, Jeffrey L. Woodhead, Paul B. Watkins, Kim L. R. Brouwer   +4 more
wiley   +1 more source

Alkaline phosphatase and acid phosphatase in health and disease - A systematic review. [PDF]

J Oral Maxillofac Pathol
Swetha S, Rao GN, Mahalakshmi V, Sathya R.   +3 more
europepmc   +1 more source

Mosaic activation of the zebrafish hsp70l heat shock promoter: Implications for interpreting transgenes

Developmental Dynamics, EarlyView.
Abstract Background The promoters and enhancers of heat shock genes, such as the 1.5‐kb promoter of the zebrafish hsp70l gene, are valuable tools for temporal activation of transgenes. It has been widely purported that heat shock treatments result in ubiquitous expression of hsp70l‐driven transgenes.
Jong‐Su Park, Xiangyun Wei
wiley   +1 more source

Alkaline Phosphatase Activity in Serum as Indicator for Skeletal Maturity in Assamese Population - An Ex-Vivo Study.

J Pharm Bioallied Sci
Bhattacharjee R, Baruah N, Bora M, Khan RUA, Das SDC.   +4 more
europepmc   +1 more source

Serum alkaline phosphatase levels at admission are associated with unfavorable prognosis in acute ischemic stroke patients undergoing endovascular thrombectomy. [PDF]

Front Neurol
Tang X, Li Q, Zhang W.
europepmc   +1 more source

Three‐dimensional observation of the muscle–tendon integration process in mouse embryos

Developmental Dynamics, EarlyView.
Abstract Background Muscle–tendon integration is a crucial step in the morphogenesis of the vertebrate locomotion system. As the limb muscle and tendon progenitor cells derive from distinct embryonic origin, their integration requires precise mutual positioning.
Ramu Sagasaki, Anzu Taniguchi, Shunsuke Oka, Mizuki Mishima, Yuki Yamasaki, Yutaro Kawa, Saundra Schlesinger, Ryo Fujita, Chisa Shukunami, Hiroshi Asahara, Masafumi Inui   +10 more
wiley   +1 more source

Neuronal alkaline phosphatase promotes the spread of Tau-induced pathology, and its blockade prevents neurodegeneration and memory loss. [PDF]

Neurotherapeutics
Soria-Tobar L, Ouro-Corredera D, Roman-Valero L, Hernández F, Millán JL, Álvarez-Castelao B, Sebastián-Serrano Á, Aivar P, Díaz-Hernández M.   +8 more
europepmc   +1 more source

High‐Strength, Fluorescent, Triboelectric Cellulose Hydrogel‐Derived Plastics Through Molecular Network Engineering for Energy Harvesting and Motion Sensing

ENERGY &ENVIRONMENTAL MATERIALS, EarlyView.
Multifunctional cellulose hydrogel‐derived plastics (FCBPs) are fabricated via a novel molecular network engineering strategy involving epoxy cross‐linking, solvent exchange, and hot‐pressing techniques. The resulting materials exhibit high mechanical strength, excellent thermal/solvent resistance, stable fluorescence, complete biodegradability, and ...
Fuyuan Lu, Yifan Jiao, Yuxuan Chen, Zhezhe Zhou, Gaobo Lou, Caicai Li, Gaojie Jiao, Mark Lynch, Jialong Wen, Xiaochun Zhang, Pingan Song, Dan Sun   +11 more
wiley   +1 more source

Letter to the editor: Commentary on "Prognostic significance of the albumin-to-alkaline phosphatase ratio in gastrointestinal cancer patients: a systematic review and meta-analysis". [PDF]

Int J Surg
Wang Y, Li P, Zhang Y.
europepmc   +1 more source