Results 181 to 190 of about 321,976 (264)

Multifunctional polycaprolactone‐based composite fibers with icariin and glutathione for effective repair of critical‐sized bone defects

BMEMat, EarlyView.
A multifunctional PCL‐based scaffold co‐delivering Icariin and Glutathione synergistically enhances osteogenesis, angiogenesis, and oxidative stress resistance, achieving near‐complete repair of critical‐sized bone defects in vivo. This cell‐free platform represents a promising strategy for accelerated bone regeneration.
Abdurohman Mengesha Yessuf, Yaqi Zhang, Bharat Prasad Sharma, Yake Wang, Tibebu Shiferaw Kassa, Abdul Qadir, Ye Jinqiu, Mohamedazeem M. Mohideen, Ahmed M. Salama, Weiguo Wang, Qidong Zhang, Yong Liu   +11 more
wiley   +1 more source

Alkaline Phosphatase-Activated NIR-II AIEgens Nanosystem for Surgical and Postoperative Closed-Loop Therapy of Advanced Osteosarcoma. [PDF]

Adv Sci (Weinh)
Liu K, Li R, Zhang L, Lu H, Yang B, Hu Q, Tao Y, Mu H, Han J, Zan P, Shen J, Zuo D, Wang H, Sun W, Zhu X.   +14 more
europepmc   +1 more source

Nacre‐inspired layered composite with excellent mechanical support and osteogenic potential for cervical interbody cage

BMEMat, EarlyView.
The cervical interbody cage needs to take both biomechanical and biological requirements into account. Here, a new‐style degradable, multicomponent, and bioinspired nacre‐like cervical interbody cage composite, which exhibits promising mechanical‐support‐related behavior and osteogenesis‐related potential, is designed and prepared.
Xiu‐Wu Guo, Shao‐Meng Wen, Tian‐Yu Xing, Yang Zhou, Chun‐Xin Wang, Chang Ge, Si‐Ming Chen, Wen‐Zhi Zhang, Shu‐Hong Yu   +8 more
wiley   +1 more source

Salivary and serum alkaline phosphatase as biomarkers in type 2 diabetes mellitus: Association with periodontal health and disease. [PDF]

Bioinformation
Desai K, Dave B, Nagrani T, Chaudhary R, Patel A, Gohil S.   +5 more
europepmc   +1 more source

A bioinspired catalytic nanoplatform for ferroptosis‐immunotherapy synergy in metastatic cancer

BMEMat, EarlyView.
The bioinspired nanoplatform MnMSN@MnP‐PEG co‐delivers manganese peroxidase and manganese ions to synergistically induce immunogenic ferroptosis and activate the cGAS‐STING pathway, eliciting potent antitumor immunity against primary and metastatic tumors.
Panpan Xue, Hai Cai, Ying Sun, Yaxin Ma, Siyuan Liu, Jinying Zhu, Yan Chen, Xuemei Zeng, Shuangqian Yan   +8 more
wiley   +1 more source

Alkaline Phosphatase Supplementation During Hypothermic and Normothermic Machine Perfusion Improves Metabolic Dysfunction in a Porcine Model of Donor Kidney Preservation. [PDF]

Transplant Direct
Steenvoorden TS, Tellez Garcia JM, van der Heijden JW, Bemelman F, Rood JAJ, Florquin S, Tammaro A, Leuvenink H, Vogt L.   +8 more
europepmc   +1 more source

Oocyte–cumulus cell interaction: a key factor in early embryo development

Biological Reviews, EarlyView.
ABSTRACT The evaluation of oocyte competence is a fundamental step in achieving successful outcomes following assisted reproduction techniques (ART). At present, however, conventional oocyte maturation assessment is carried out by morphological observation, which is a subjective method that does not consider molecular features.
Marc Torres‐Garrido, Marc Yeste, Yentel Mateo‐Otero   +2 more
wiley   +1 more source

Targeted Alkaline Phosphatase Therapy Enhances Alveolar Bone Healing in X-Linked Hypophosphatemia in Mice. [PDF]

J Periodontal Res
Phanrungsuwan A, Donnelly B, Millán JL, Foster BL.   +3 more
europepmc   +1 more source

Virtual Twin Approach Using Physiologically Based Pharmacokinetic Modeling to Support Precision Dosing of Valproic Acid in Geriatric Patients

Clinical Pharmacology &Therapeutics, EarlyView.
Personalized dosing is particularly important for drugs with narrow therapeutic indices in geriatric patients, who exhibit substantial physiological variability and limited pharmacokinetic (PK) evidence to guide individualized dose selection. Valproic acid (VPA) is an effective treatment option for bipolar disorder in older adults, yet dosing largely ...
Yoo Jin Jang, Dong‐Gyu Heo, Eunjin Hong   +2 more
wiley   +1 more source

Intra-individual fluctuations in alkaline phosphatase predict mortality and CKD progression: insights from a large CKD cohort. [PDF]

Clin Kidney J
Kim Y, Wu PH, Kwon S, Han SH, Lee J, Lin MY, Chiu YW, Son NH, Paek JH, Kim DK, Han S, Lim CS, Hwang SJ, Lee JP.   +13 more
europepmc   +1 more source