Results 41 to 50 of about 321,976 (264)
Measurement of Secreted Embryonic Alkaline Phosphatase
Bio-Protocol, 2023 Secreted reporters have been demonstrated to be simple and useful tools for analyzing transcriptional regulation in mammalian cells. The distinctive feature of these assays is the ability to detect reporter gene expression in the culture supernatant ...
Meiyan Wang, Xinyi Wang, Haifeng Ye
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Arthritis Care &Research, EarlyView.Objective We aimed to construct and evaluate the first laboratory‐based frailty index (FI‐Lab) for predicting adverse outcomes in systemic lupus erythematosus (SLE) and to compare its predictive ability to that of an existing clinical FI. Methods We used data from a single‐center prospective cohort of adult patients with SLE whose baseline visit ...
Grace Burns +2 more
wiley +1 more source
Clinics, 2015 OBJECTIVE: Bone metastasis is frequently associated with nasopharyngeal carcinoma. The diagnosis and follow-up of bone metastatic patients usually relies on skeletal X-ray and bone scintigraphy, which are time-consuming and costly.
Ying Jin +3 more
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The Kinetics of Alkaline Phosphatase
Journal of Biological Chemistry, 1966 The advantages of an integrated rate equation for the analysis of the reaction kinetics of the alkaline phosphatase of Escherichia coli were demonstrated.
W T, Jenkins, L, D'Ari
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Advanced Healthcare Materials, EarlyView.Nanoemulsion delivery of a TLR7 agonist enhances safety and promotes colocalization with Leishmania‐infected macrophages in skin lesions, enabling a ∼2‐log reduction in parasite burden. However, tissue‐level constraints and TLR‐driven regulatory feedback generate a mixed immune response that limits complete parasite clearance.
Carmen Palomino‐Cano +11 more
wiley +1 more source
Talanta OpenAbnormal alkaline phosphatase levels have been associated with several diseases, including tumor growth, diabetes, liver dysfunction and so on. Generally, the occurrence and prognosis of these diseases can be reflected by the serum alkaline phosphatase ...
Chen-Xi Zhao, Xiao-Xia Li, Yang Shu
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Advanced Materials, EarlyView.A multifunctional bioactive PEEK‐based implant (Mn@p/MBG‐SPEEK) is engineered to combat implant‐associated infections while promoting osteogenesis. The hybrid surface activates PI3K/Akt/mTOR and AP‐1 signaling pathways for osteogenic differentiation, while Mn coordination induces electronic coupling that narrows the HOMO‐LUMO energy gap and enhances ...
Zhiyan Xu +7 more
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Immunity, Inflammation and DiseaseAim Kikuchi‐Fujimoto disease (KFD) rarely affects pediatric patients and is characterized by prolonged fever and cervical lymphadenopathy. The diagnosis of KFD remains challenging and often requires an invasive biopsy.
Shintaro Fujiwara +2 more
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Advanced Materials, EarlyView.Targeting cancer‐associated fibroblasts (CAFs) with fibroblast activation protein (FAP)‐directed nanoprobes for multimodal imaging and photothermal remodeling of the immunosuppressive microenvironment to enhance immunotherapy in triple‐negative breast cancer (TNBC).
Ling Zhan +6 more
wiley +1 more source
Single-Molecule Analysis of Alkaline Phosphatase
Kinases and PhosphatasesChemical studies usually consist of measurements made on large ensembles of molecules with data representing average values for the population. It has been shown that individual molecules of a given enzyme have different properties. Large-scale averaging
Douglas B. Craig
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