Results 191 to 200 of about 287,843 (358)

Dietary‐Driven Gene Expansion

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Gene duplication has been shown to drive molecular evolution, with dietary pressures expanding detoxification genes across species. In humans, CYP2D6 gene duplications enhance alkaloid and drug metabolism, reflecting ancient dietary adaptations. Similarly, tobacco‐feeding aphids amplify CYP6CY3 for nicotine and insecticide resistance, and as recently ...
Magnus Ingelman‐Sundberg
wiley   +1 more source

Redefining the Skin Barrier: A Microbiome‐Integrated Multilayered Defense Model

open access: yesBarrier Immunity, EarlyView.
ABSTRACT The skin constitutes a dynamic interface orchestrating a sophisticated multilayered defense system comprising physical, chemical, immune, and microbial barriers. This review synthesizes current understanding of the structural and functional integration of these barriers, emphasizing their synergistic interactions in maintaining cutaneous ...
Jingjing Xia   +4 more
wiley   +1 more source

Interpretation of in vitro concentration‐response data for risk assessment and regulatory decision‐making: Report from the 2022 IWGT quantitative analysis expert working group meeting

open access: yesEnvironmental and Molecular Mutagenesis, EarlyView.
Abstract Quantitative risk assessments of chemicals are routinely performed using in vivo data from rodents; however, there is growing recognition that non‐animal approaches can be human‐relevant alternatives. There is an urgent need to build confidence in non‐animal alternatives given the international support to reduce the use of animals in toxicity ...
Marc A. Beal   +14 more
wiley   +1 more source

Emerging Techniques for the Recovery of Bioactive Compounds From Sweet Potato Leaves [Ipomoea batatas (L.) Lam] and Their Functional Health Benefits

open access: yesFood Bioengineering, EarlyView.
Emerging green extraction techniques are revolutionizing the recovery of bioactive compounds from sweet potato (Ipomoea batatas [L.] Lam) leaves. These approaches enhance the yield and stability of key phytochemicals like caffeoylquinic acids, flavonoids, and polyphenols, which offer potent antioxidants, anti‐inflammatory, and metabolic health benefits.
M. H. A. Jahurul, S. Islam
wiley   +1 more source

Home - About - Disclaimer - Privacy