Results 191 to 200 of about 225,386 (346)

High‐throughput liquid chromatography‐vacuum differential mobility spectrometry‐mass spectrometry for the analysis of isomeric drugs of abuse in human urine

Drug Testing and Analysis, EarlyView.
This report describes the potential of vacuum differential mobility spectrometry (DMS) as an additional separation dimension to reduce liquid chromatography (LC‐MS) analysis time while maintaining good quantitative performance. A 1‐min trap/elute LC‐vDMS‐SIM/MS method for quantification of 11 drugs of abuse was developed and applied to the analysis of ...
Maria Fernanda Cifuentes Girard, Patrick Knight, Gérard Hopfgartner   +2 more
wiley   +1 more source

AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury

, 2022
Hepatology, EarlyView.
Robert J. Fontana, Iris Liou, Adrian Reuben, Ayako Suzuki, M. Isabel Fiel, William Lee, Victor Navarro   +6 more
wiley   +1 more source

Increased Drug‐Loading Enhances the Activity of Ellipticine in Poly(N‐(2‐hydroxypropyl) Methacrylamide) PHPMA‐Based Polymeric Micelles in 2D and 3D Cancer Cell Models

Macromolecular Chemistry and Physics, Volume 224, Issue 1, January 2023., 2023
This study investigates the cellular uptake and penetration of polymeric micelles with different drug loading contents in 2D and 3D cancer cell models. The higher toxicity in micelles with higher drug loading content is associated with higher cellular uptake in both monolayer cell culture and multicellular tumor spheroids, monitored using confocal ...
Russul Mamdooh Al‐Nakashli, Cheng Cao, Radhika Raveendran, Hongxu Lu, Martina H. Stenzel   +4 more
wiley   +1 more source

Plant Alkaloids as Promising Anticancer Compounds with Blood-Brain Barrier Penetration in the Treatment of Glioblastoma: In Vitro and In Vivo Models. [PDF]

Molecules
Ożarowski M, Karpiński TM, Czerny B, Kamiński A, Seremak-Mrozikiewicz A.   +4 more
europepmc   +1 more source

Studies on the Alkaloids of Rutaceaous Plants. IV

, 1958
Masao Tomita, Hisashi Ishii
openalex   +2 more sources

The distribution and interrelationships of the alkaloids in the bark of Cinchona Ledgeriana [PDF]

, 1948
Heidi Birch, L. R. Doughty
openalex   +1 more source

Associations Between Self‐Reported Cocaine Use Patterns and Cocaine and Its Metabolites in Hair: Implications for Clinical and Forensic Practices

Drug Testing and Analysis, EarlyView.
This study demonstrates that concentrations of cocaine and its main metabolites in hair reliably predict an individual's actual intensity of cocaine use and effectively differentiate between dependent and non‐dependent users. ABSTRACT In forensic toxicology, it has been debated if hair testing allows an estimation of the intensity of cocaine use—an ...
Simon Grison, Lydia Johnson‐Ferguson, Matthias Vonmoos, Markus R. Baumgartner, Boris B. Quednow   +4 more
wiley   +1 more source

Deciphering Steroidal and Aporphine Alkaloids as Antileukemic Agents by Approaches of Molecular Networking and Metabolomics. [PDF]

ACS Omega
Liu S, Farias KS, Zanuncio VSS, Damasceno Júnior GA, Alves FM, Paredes-Gamero EJ, de Souza KFS, Pessatto LR, Torquato HFV, Carollo CA, Silva DB.   +10 more
europepmc   +1 more source

Comparative Computational Study on the Robinson–Gabriel Synthesis and Bischler–Napieralski Reaction: DFT Investigation of T3P®‐mediated Ring Closure

European Journal of Organic Chemistry, Accepted Article.
Previously, we reported novel and efficient methods for the Bischler–Napieralski and Robinson–Gabriel reactions of tryptamides under microwave conditions using T3P® reagent. Furthermore, we presented the first computational study on Bischler–Napieralski reaction of Nb‐benzoyltryptamine with T3P® leading to 1‐phenyl‐3,4‐dihydro‐β‐carboline.
Patrik Pollák, Mátyás Milen, Balázs Volk, Péter Ábrányi-Balogh   +3 more
wiley   +1 more source

Healing and leishmanicidal activity of <i>Zanthoxylum rhoifolium</i> Lam. [PDF]

Front Chem
Correa-Barbosa J, Brígido HPC, Matte BF, Campos PS, Lamers ML, Sodré DF, Nascimento PHC, Ferreira GG, Vale VV, Marinho AMDR, Siqueira JES, Coelho-Ferreira MR, Monteiro MC, Dolabela MF.   +13 more
europepmc   +1 more source