Results 211 to 220 of about 225,386 (346)

Divergent Total Syntheses of 7,20‐Epoxy, 3,20‐Epoxy and 6,7‐seco‐ent‐Kaurane Diterpenoids

open access: yesEuropean Journal of Organic Chemistry, Accepted Article.
The genus Isodon is a well‐known traditional medicinal herb that serves as a rich source of cytotoxic ent‐kaurane diterpenoids, which bear the same tetracyclic core of ent‐kaurane with different oxygenation, bond‐cleavage and rearrangement patterns.
Bo Wang   +6 more
wiley   +1 more source

Enantioselective Anion‐Binding‐Catalyzed Nucleophilic Addition to 4‐Quinolones

open access: yesEuropean Journal of Organic Chemistry, EarlyView.
The first organocatalytic enantioselective formal 1,4‐addition to 4‐quinolones has been developed. This method relies on chiral triazole‐based anion‐binding catalysis using enol nucleophiles, complementing previous metal catalytic approaches. Moderate to good yields and enantioselectivities were achieved by in situ silylation and formation of a key ...
Martin Aleksiev   +2 more
wiley   +1 more source

Interpretation of in vitro concentration‐response data for risk assessment and regulatory decision‐making: Report from the 2022 IWGT quantitative analysis expert working group meeting

open access: yesEnvironmental and Molecular Mutagenesis, EarlyView.
Abstract Quantitative risk assessments of chemicals are routinely performed using in vivo data from rodents; however, there is growing recognition that non‐animal approaches can be human‐relevant alternatives. There is an urgent need to build confidence in non‐animal alternatives given the international support to reduce the use of animals in toxicity ...
Marc A. Beal   +14 more
wiley   +1 more source

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