Results 51 to 60 of about 168,537 (253)

A new aporphine alkaloid from Sabia yunnanensis

, 2007
A new aporphine alkaloid, 1-hydroxy-2,3-dimethoxy-6-formyl-6a,7-dehydroaporphine, along with 15 known compounds have been isolated from the stems and leaves of Sabia yunnanensis.
Tang, TJ, Deng, Y, Li, X, Wu, FE, Wu, FE, Chinese Acad Sci, Chengdu Inst Biol, Chengdu 610041, Peoples R China.   +4 more
core  

'Dopamine-first' mechanism enables the rational engineering of the norcoclaurine synthase aldehyde activity profile. [PDF]

, 2015
Norcoclaurine synthase (NCS) (EC 4.2.1.78) catalyzes the Pictet-Spengler condensation of dopamine and an aldehyde, forming a substituted (S)-tetrahydroisoquinoline, a pharmaceutically important moiety.
Nicholas H. Keep, Markus C. Gershater, Helen C. Hailes, Ward, J.M., Pesnot, T, Eleanor D. Lamming, Pesnot, T., Thomas Pesnot, Hailes, HC, Gershater, M.C., Ward, JM, Lamming, E.D., Keep, Nicholas H., Altin Sula, Keep, NH, Hailes, H.C., Lichman, B.R., John M. Ward, Sula, Altin, Benjamin R. Lichman, Lichman, BR, Gershater, MC, Sula, A, Lamming, ED   +23 more
core   +1 more source

Real‐time monitoring of root dielectric properties for assessing crop plant damage caused by foliar application of glyphosate

Applications in Plant Sciences, EarlyView.
Abstract Premise There is a knowledge gap regarding how foliar injury and restricted water uptake can be detected by measuring root dielectric response. This pot study nondestructively evaluated the efficiency of real‐time dielectric measurement to monitor the effects of glyphosate spraying.
Imre Cseresnyés, Anna Füzy, Tünde Takács   +2 more
wiley   +1 more source

Integration of Nutrition and Organic Agriculture Framework in Managing Gastrointestinal Nematodes in Ruminants

Animal Research and One Health, EarlyView.
Gastrointestinal nematode infections damage the gastrointestinal epithelial tissues of ruminants, affecting nutrient utilization and overall production performance. This review outlines host‐gastrointestinal nematode interactions and discusses integrated control strategies, including nutritional supplementation, grazing management, vaccines, and ...
Wenxun Chen, Xiangfang Tang, Yimin Zhuang, Shengjun Zhao, Ying Ren, Xiaokang Lv   +5 more
wiley   +1 more source

From anthelmintic to neuro‐oncology: A systematic review of mebendazole repurposing for brain tumour therapy

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Mebendazole (MBZ), a benzimidazole anthelmintic with established clinical use, has emerged as a repurposing candidate for primary brain tumours due to its multimodal anticancer actions and central nervous system penetrance. This systematic review synthesizes preclinical and clinical evidence evaluating MBZ's efficacy, mechanisms of action ...
Ciara B. Blum, Milli McMenamin, Tessa Khoo, John M. Edwin, Prathibha Jose, Liam A. O’Callaghan   +5 more
wiley   +1 more source

The potential impact of H1 antihistamines on clinical outcomes in NSCLC patients undergoing EGFR‐TKIs treatment

British Journal of Clinical Pharmacology, EarlyView.
Background Epidermal growth factor receptor–tyrosine kinase inhibitors (EGFR‐TKIs) have substantially improved outcomes in non‐small cell lung cancer (NSCLC); however, the development of treatment resistance remains a major clinical challenge. This study examines the association between concomitant prescriptions of H1‐antihistamines (H1AHs) and ...
Van Thuan Nguyen, Ngoc Hoang Le, Nhu Quynh Phan, Toan Trung Duong, Le Thi Anh Thu, Hsuan‐Chia Yang, Chih‐Wei Huang, Min‐Huei Hsu, Jason C. Hsu, Chien‐Tien Su, Phung‐Anh Nguyen   +10 more
wiley   +1 more source

Transcriptomic signatures of experimental alkaloid consumption in a poison frog [PDF]

, 2019
In the anuran family Dendrobatidae, aposematic species obtain their toxic or unpalatable alkaloids from dietary sources, a process known as sequestering.
Lötters, Stefan, Schulz, Stefan, Miguel Vences, Stefan Schulz, Künzel, S., Saporito, R., Wollenberg Valero, K., Sanchez, Eugenia, Grau, Jose H., Ralph A. Saporito, Grau, J., Jose H. Grau, Saporito, Ralph A., Rodríguez, A., Vences, M., Lötters, S., Eva Ringler, Katharina C. Wollenberg Valero, Künzel, Sven, Schulz, S., Rodríguez, Ariel, Sven Künzel, Ringler, E., Ringler, Eva, Wollenberg Valero, Katharina C., Stefan Lötters, Sanchez, E., Eugenia Sanchez, Ariel Rodríguez, Vences, Miguel   +29 more
core   +2 more sources

Synthesis and Structures of Novel Chiral Cyclic Hypervalent Iodine(III) Reagents for Metal‐Free Ligand‐Transfer Reactions

Chemistry – A European Journal, EarlyView.
Several new chiral cyclic hypervalent iodine(III) reagents have been synthesized and characterized. Carbon‐based ligands were successfully installed onto the hypervalent iodine centers, giving thus access to novel chiral cyano‐, trifluoromethyl‐ or alkynyl‐bearing λ3‐iodanes.
Emmanuel Valzer, Jean‐Marc Sotiropoulos, Karinne Miqueu, Laurent Pouységu, Stéphane Quideau   +4 more
wiley   +1 more source

A novel alkaloid from Mitrephora maingayi

, 2005
A novel alkaloid, maingayinine, together with dicentrinone, dicentrinene, L-2-O-methyl-chiro-inositol, allantoin, glaucine, N-phenyl-2-naphthylamine, terephthalic acid and ayanin, was isolated from the twigs of Mitrephora maingayi Hook (Annonaceae ...
Ye, Q, Zhang, GL, Chinese Acad Sci, Chengdu Inst Biol, Chengdu 610041, Peoples R China., Li, BG, Yu, R, Zhang, GL   +4 more
core  

Citronamine A, an Antiplasmodial Isoquinoline Alkaloid from the Australian Marine Sponge Citronia astra

, 2020
Citronamine A (1), an isoquinoline alkaloid containing an unprecedented pentacyclic ring system, was isolated from the Australian marine sponge Citronia astra.
Prebble, Dale W, Carroll, Anthony R, Avery, Vicky M, Holland, Darren C, Robertson, Luke P   +4 more
core   +1 more source