Results 31 to 40 of about 115,190 (149)

Comparison of different extraction solvents for assay of the polyphenol content in the peel and pulp of 21 apple cultivars from Macedonia

Macedonian Journal of Chemistry and Chemical Engineering, 2016
Apples (Malus domestica Borkh.) contain a large array of phenolic compounds belonging to flavonoids and non-flavonoids. This study systematically evaluates the polyphenolic content of 21 apple cultivars from the Republic of Macedonia, both commercial and
Ana Petkovska, Viktor Gjamovski, Marina Stefova   +2 more
doaj   +1 more source

Topping and grafting affect the alkaloid content and gene expression patterns of tobacco (Nicotiana tabacum L.)

Plant Direct, 2023
In this study, we aimed to determine molecular mechanisms underlying the effects of topping and grafting in tobacco (Nicotiana tabacum L.) by comparing the alkaloid contents and enrichment pathways of differentially expressed genes (DEGs) among plants ...
Mengyue Zhang, Yuanyuan Zhao, Hongzhi Shi   +2 more
doaj   +1 more source

Cephalotaxus Alkaloids

, 2017
Cephalotaxus alkaloids represent a family of plant secondary metabolites known for 60 years. Significant activity against leukemia in mice was demonstrated for extracts of Cephalotaxus. Cephalotaxine (CET) (1), the major alkaloid of this series was isolated from Cephalotaxus drupacea species by Paudler in 1963.
Pérard-Viret, Joelle, Quteishat, Laith, Alsalim, Rana, Royer, Jacques, Dumas, Françoise   +4 more
openaire   +3 more sources

A Co-Culturing Approach Enables Discovery and Biosynthesis of a Bioactive Indole Alkaloid Metabolite

Molecules, 2020
Whole-genome sequence data of the genus Streptomyces have shown a far greater chemical diversity of metabolites than what have been discovered under typical laboratory fermentation conditions.
Fleurdeliz Maglangit, Qing Fang, Kwaku Kyeremeh, Jeremy M. Sternberg, Rainer Ebel, Hai Deng   +5 more
doaj   +1 more source

Exploration of the Electrophilic Reactivity of the Cytotoxic Marine Alkaloid Discorhabdin C and Subsequent Discovery of a New Dimeric C-1/N-13-Linked Discorhabdin Natural Product

Marine Drugs, 2020
The cytotoxic marine natural product discorhabdin C contains a 2,6-dibromo-cyclohexa-2,5-diene moiety, previously proposed to be a critical feature required for biological activity.
Cary F. C. Lam, Melissa M. Cadelis, Brent R. Copp   +2 more
doaj   +1 more source

Predictive analytical workflow for rapid structure elucidation and in silico toxicological qualification of an unidentified impurity in cefixime granules for oral suspension

Acta Pharmaceutica
During in-use stability testing of cefixime granules for oral suspension, an impurity with a relative retention time of 0.19 was consistently detected and increased during storage.
Mitrevska Ivana, Chachorovska Marina, Petrushevski Gjorgji   +2 more
doaj   +1 more source

Natural Compounds as Guides for the Discovery of Drugs Targeting G-Protein-Coupled Receptors

Molecules, 2020
G protein-coupled receptors (GPCRs), which constitute the most populous family of the human proteome, are the target of 35–45% of approved therapeutic drugs. This review focuses on natural products (excluding peptides) that target GPCRs.
Joan Serrano-Marín, Irene Reyes-Resina, Eva Martínez-Pinilla, Gemma Navarro, Rafael Franco   +4 more
doaj   +1 more source

Мultivariate analysis for rapid screening and prediction of solid-state compatibility in pharmaceutical preformulation studies-paving the road for machine learning

Macedonian Journal of Chemistry and Chemical Engineering
Multivariate analysis models were developed to evaluate the results obtained from a compatibility study designed for ibuprofen with a large group of different types of excipients, as a possible approach for rapid screening of the incompatibility between
Elena Cvetkovska Bogatinovska, Nikola Geškovski, Gjorgji Petrushevski, Viktor Stefov   +3 more
doaj   +1 more source

Acalypha Indica: Pemanfaatan dan Bioaktivitasnya

Titian Ilmu: Jurnal Ilmiah Multi Sciences, 2019
Acalypha indica (AI) atau yang dikenal dengan nama daun anting-anting telah lama digunakan masyarakat Indonesia sebagai obat tradisional. Pemanfaatan tumbuhan sebagai obat tradisional berhubungan dengan kandungan metabolit sekunder dan bioaktivitasnya ...
Marina Silalahi
doaj   +1 more source

Marine Streptomyces-Derived Novel Alkaloids Discovered in the Past Decade

Marine Drugs
Natural alkaloids originating from actinomycetes and synthetic derivatives have always been among the important suppliers of small-molecule drugs. Among their biological sources, Streptomyces is the highest and most extensively researched genus.
Zijun Liu, Wenyan Sun, Zhe Hu, Wei Wang, Huawei Zhang   +4 more
doaj   +1 more source