Results 91 to 100 of about 10,817 (260)

ALKBH8-mediated formation of a novel diastereomeric pair of wobble nucleosides in mammalian tRNA [PDF]

, 2011
Mammals have nine different homologues (ALKBH1–9) of the Escherichia coli DNA repair demethylase AlkB. ALKBH2 is a genuine DNA repair enzyme, but the in vivo function of the other ALKBH proteins has remained elusive.
Falnes, P. O., Kirpekar, F., Klungland, A., Krokan, H. E., Leihne, V., Leszczynska, G., Lien, G. F., Malkiewicz, A., Songe-Moller, L., Vagbo, C. B., van den Born, E.   +10 more
core   +1 more source

Inhibition of Alkbh5 Attenuates Lipopolysaccharide‐Induced Lung Injury by Promoting Ccl1 m6A and Treg Recruitment

Cell Proliferation, EarlyView.
In septic lung injury mice, Alkbh5 is highly expressed, promoting the demethylation of m6A on Ccl1 mRNA, thereby reducing the stability of Ccl1 mRNA and decreasing Ccl1 expression. This, in turn, leads to reduced recruitment of Tregs, further exacerbating the symptoms of septic lung injury.
Hongdou Ding, Xinnan Xu, Yaoyao Zhu, Xinyu Ling, Li Xu   +4 more
wiley   +1 more source

Dataset for Spectroscopic, Structural and Dynamic Analysis of Human Fe(II)/2OG-Dependent Dioxygenase ALKBH3

Data, 2023
Fe(II)/2OG-dependent dioxygenases of the AlkB family catalyze a direct removal of alkylated damages in the course of DNA and RNA repair. A human homolog of the E. coli AlkB ALKBH3 protein is able to hydroxylate N1-methyladenine, N3-methylcytosine, and N1-
Lyubov Yu. Kanazhevskaya, Alexey A. Gorbunov, Polina V. Zhdanova, Vladimir V. Koval   +3 more
doaj   +1 more source

Molecular modelling and Function Prediction of hABH7, human homologue of _E. coli_ ALKB7 [PDF]

, 2011
Human homologues of ALKB protein have shown the prime role in DNA damaging drugs, used for cancer therapy. Little is known about structure and function of hABH7, one of the members of this superfamily. Therefore, in the present study we intend to predict
Ambarish Sharan Vidyarthi, Mr. Shankaracharya, Saibal Das   +2 more
core   +1 more source

Extreme multivalency and a composite short linear motif facilitate PCNA‐binding, localisation and abundance of p21 (CDKN1A)

The FEBS Journal, EarlyView.
Regions flanking the PCNA‐binding motif in p21 contribute to high‐affinity binding through complementary charges without specific contacts. These regions affect p21 abundance, but their exact Lys/Arg composition is unimportant for PCNA binding. Conversely, both context and Lys/Arg composition of the N‐terminal flanking region are crucial for p21 ...
Signe Simonsen, Fia B. Larsen, Caroline K. Søgaard, Nicolas Jonsson, Kresten Lindorff‐Larsen, Per Bruheim, Marit Otterlei, Rasmus Hartmann‐Petersen, Birthe B. Kragelund   +8 more
wiley   +1 more source

Sequence Dependent Repair of 1,N6-Ethenoadenine by DNA Repair Enzymes ALKBH2, ALKBH3, and AlkB

Molecules, 2021
Mutation patterns of DNA adducts, such as mutational spectra and signatures, are useful tools for diagnostic and prognostic purposes. Mutational spectra of carcinogens derive from three sources: adduct formation, replication bypass, and repair.
Rui Qi, Ke Bian, Fangyi Chen, Qi Tang, Xianhao Zhou, Deyu Li   +5 more
semanticscholar   +1 more source

METTL3/YTHDF3 m6A axis promotes ferroptosis in diabetic kidney disease by stabilizing TfR1

Journal of Diabetes Investigation, EarlyView.
METTL3/YTHDF3 m6A axis promoted ferroptosis in DKD by stabilizing TfR1, which could provide a reference for DKD treatment. ABSTRACT Objective Diabetic kidney disease (DKD) is a common complication of diabetes. N6‐Methyladenosine (m6A) modification is a widely studied epigenetic mechanism.
Jinmei Zhang, Xiaoping Zhou, Bin Wang, Yan Yin, Daihao Wei, Kun Li   +5 more
wiley   +1 more source

Profiling Mechanisms of Alkane Hydroxylase Activity In Vivo Using the Diagnostic Substrate Norcarane [PDF]

, 2007
SummaryMechanistically informative chemical probes are used to characterize the activity of functional alkane hydroxylases in whole cells. Norcarane is a substrate used to reveal the lifetime of radical intermediates formed during alkane oxidation ...
Alexander-Ozinskas, Marselle, Austin, Rachel N., Bertrand, Erin M., Chae, Jong-Chan, Danahy, Michael, Deng, Dayi, Groves, John T., Moe, Luke A., Rozhkova-Novosad, Elena A., van Beilen, Jan B., Zylstra, Gerben J.   +10 more
core   +1 more source

Gaining insights into epigenetic memories through artificial intelligence and omics science in plants

Journal of Integrative Plant Biology, EarlyView.
This review explores how artificial intelligence and machine learning predict plant behavior in response to environmental stress by modeling molecular regulatory networks of plant stress responses. Their combined application with omics methods opens new avenues in understanding the functioning of plant memory and future plant memory‐based plant ...
Judit Dobránszki, Valya Vassileva, Dolores R. Agius, Panagiotis Nikolaou Moschou, Philippe Gallusci, Margot M.J. Berger, Dóra Farkas, Marcos Fernando Basso, Federico Martinelli   +8 more
wiley   +1 more source

The bacterial community structure of hydrocarbon-polluted marine environments as the basis for the definition of an ecological index of hydrocarbon exposure [PDF]

, 2013
The aim of this study was to design a molecular biological tool, using information provided by amplicon pyrosequencing of 16S rRNA genes, that could be suitable for environmental assessment and bioremediation in marine ecosystems.
Commendatore, Marta G., Dionisi, Hebe Monica, Gil, Mónica N., Lozada, Mariana, Marcos, Magalí Silvina   +4 more
core   +2 more sources