Results 91 to 100 of about 6,739 (216)

ALKBH5 Inhibits YTHDF2‐m6A‐Mediated Degradation of RCN1 mRNA to Promote Keloid Formation by Activating IRE1α‐XBP1‐Mediated ER Stress

Journal of Cosmetic Dermatology, Volume 24, Issue 4, April 2025.
ABSTRACT Background Reticulocalbin 1 (RCN1) was reported to be upregulated in keloid, but its molecular mechanism remains unclear. The aim of this study is to investigate the role of RCN1 in keloid. Methods The expression of RCN1 was detected in keloid tissues. Keloid fibroblasts were transfected with RCN1 overexpression vector.
Min Shi, Lu Zhang, Fangfang Bi, Zhuo Zhou   +3 more
wiley   +1 more source

Lactylation of HDAC1 Confers Resistance to Ferroptosis in Colorectal Cancer

Advanced Science, Volume 12, Issue 12, March 27, 2025.
HDAC inhibitor decreases HDAC1K412 lactylation to sensitize colorectal cancer to ferroptosis and the combination of HDAC inhibitor and ferroptosis inducers can be a promising therapeutic strategy for colorectal cancer. Abstract Colorectal cancer (CRC) is highly resistant to ferroptosis, which hinders the application of anti‐ferroptosis therapy. Through
Zhou Yang, Wei Su, Qinglin Zhang, Lili Niu, Baijie Feng, Yu Zhang, Feng Huang, Jiaxin He, Qinyao Zhou, Xin Zhou, Longjun Ma, Jingwan Zhou, Yuanrong Wang, Wenjing Xiong, Jun Xiang, Zhilin Hu, Qiang Zhan, Bing Yao   +17 more
wiley   +1 more source

Diversity of Metabolically Active Bacteria in Water-Flooded High-Temperature Heavy Oil Reservoir

Frontiers in Microbiology, 2017
The goal of this work was to study the overall genomic diversity of microorganisms of the Dagang high-temperature oilfield (PRC) and to characterize the metabolically active fraction of these populations.
Tamara N. Nazina, Natalya M. Shestakova, Ekaterina M. Semenova, Alena V. Korshunova, Nadezda K. Kostrukova, Tatiana P. Tourova, Liu Min, Qingxian Feng, Andrey B. Poltaraus   +8 more
doaj   +1 more source

Wilms' tumor 1‐associated protein aggravates ischemic stroke by promoting M1 polarization of microglia by enhancing PTGS2 mRNA stability in an m6A‐dependent manner

Cell Biology International, Volume 49, Issue 3, Page 288-302, March 2025.
Abstract Mounting evidence indicates the involvement of N6‐methyladenosine (m6A) alterations in diverse neurological disorders and the activation of microglia. However, the role of m6A methyltransferase Wilms' tumor 1‐associated protein (WTAP) in regulating microglial polarization during ischemic stroke (IS) remains unknown. We performed bioinformatics
Haijing Sui, Chang Liu, Zhenyu Sun, Hongjie Xi   +3 more
wiley   +1 more source

Understanding plant-microbe interactions for phytoremediation of petroleum-polluted soil.

PLoS ONE, 2011
Plant-microbe interactions are considered to be important processes determining the efficiency of phytoremediation of petroleum pollution, however relatively little is known about how these interactions are influenced by petroleum pollution.
Ming Nie, Ming Nie, Yijing Wang, Jiayi Yu, Ming Xiao, Lifen Jiang, Ji Yang, Changming Fang, Jiakuan Chen, Bo Li   +9 more
doaj   +1 more source

Sequence analysis of 16S rDNA, gyrB and alkB genes of plant-associated Rhodococcus species from Tunisia.

International Journal of Systematic and Evolutionary Microbiology, 2020
The genus Rhodococcus contains several species with agricultural, biotechnological and ecological importance. Within this genus, many phyllosphere, rhizosphere and endosphere strains are plant growth promoting bacteria, whereas strains designated as R ...
S. Dhaouadi, A. Mougou, Chaojun Wu, M. Gleason, A. Rhouma   +4 more
semanticscholar   +1 more source

Detection, molecular function and mechanisms of m5C in cancer

Clinical and Translational Medicine, Volume 15, Issue 3, March 2025.
The role of m5C in cancers. The role of m5C regulators‐ writers, erasers, and readers‐ in various cancer types, including NSCLC, PCa, GC, AML, BCa, and HCC. Abstract Interest in RNA posttranscriptional modifications, particularly 5‐methylcytosine (m5C), has surged in recent years.
Linhui Zhang, Yuelong Li, Liqing Li, Fei Yao, Maoping Cai, Dingwei Ye, Yuanyuan Qu   +6 more
wiley   +1 more source

Effects of changes in intracellular iron pool on AlkB-dependent and AlkB-independent mechanisms protecting E.coli cells against mutagenic action of alkylating agent

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 2015
An Escherichia coli hemH mutant accumulates protoporphyrin IX, causing photosensitivity of cells to visible light. Here, we have shown that intracellular free iron in hemH mutants is double that observed in hemH(+) strain. The aim of this study was to recognize the influence of this increased free iron concentration on AlkB-directed repair of alkylated
Anna Sikora, Katarzyna Pawlak, Małgorzata Dylewska, Jarosław Poznański, Tomasz Pilżys, Elżbieta Grzesiuk, Jan Piwowarski, Michał Marcinkowski, Agnieszka M. Maciejewska, Wioletta Jakubczak   +9 more
openaire   +4 more sources

Identity and mechanisms of alkane-oxidizing metalloenzymes from deep-sea hydrothermal vents

Frontiers in Microbiology, 2013
Six aerobic alkanotrophs (organism that can metabolize alkanes as their sole carbon source) isolated from deep-sea hydrothermal vents were characterized using the radical clock substrate norcarane to determine the metalloenzyme and reaction mechanism ...
Rachel Narehood Austin, Erin M. Bertrand, Erin M. Bertrand, John T Groves, Costantino eVetriani, Ramaydalis eKeddis   +5 more
doaj   +1 more source

Structural basis for substrate discrimination byE. colirepair enzyme, AlkB

RSC Advances, 2018
Positive charge on methylated nucleotides is a prime criterion for substrate recognition byE. coliAlkB.
Namrata Jayanth, Nirmala Ogirala, Anil Yadav, Mrinalini Puranik   +3 more
openaire   +4 more sources