Results 111 to 120 of about 10,817 (260)

Conformational and Mechanistic Studies of AlkB and AlkBH2 DNA Demethylases

The FASEB Journal, 2019
DNA demethylases play a crucial role in DNA repair mechanisms and have been linked to pathologies. AlkB enzyme and its human homolog AlkBH2 have been very intensively studied both experimentally and computationally. It is well known also that AlkB exhibits broader substrate specificity than AlkBH2.
Tatyana G. Karabencheva-Christova, Christo Z. Christov, Rajeev Ramanan, Shobhit S. Chaturvedi, Sodic Waheed   +4 more
openaire   +2 more sources

Diversity and abundance of n-alkane-degrading bacteria in the near-surface soils of a Chinese onshore oil and gas field [PDF]

Biogeosciences, 2013
Alkane-degrading bacteria have long been used as an important biological indicator for oil and gas prospecting, but their ecological characteristics in hydrocarbon microseep habitats are still poorly understood. In this study, the diversity and abundance
K. Xu, Y. Tang, C. Ren, K. Zhao, Y. Sun
doaj   +1 more source

Cloning protocol and sequence analysis of the alkB gene in Gordonia otitidis [PDF]

, 2017
A bacteria, Gordonia otitidis, was previously isolated from soil at the University of the Fraser Valley Abbotsford campus based on its ability to metabolize used motor oil.

core   +1 more source

The Arabidopsis epitranscriptome [PDF]

, 2015
The most prevalent internal modification of plant messenger RNAs, N6-methyladenosine (m6A), was first discovered in the 1970s, then largely forgotten. However, the impact of modifications to eukaryote mRNA, collectively known as the epitranscriptome, has
Fray, Rupert G., Simpson, Gordon G.
core   +2 more sources

Mitigation of Ferroptosis in Diabetic Kidney Disease Through Mesenchymal Stem Cell Intervention via the Smad2/3/METTL3/S1PR1 Axis

The FASEB Journal, Volume 39, Issue 12, 30 June 2025.
MSCs modulate ferroptosis in DKD via Smad2/3/METTL3/S1PR1 axis. ABSTRACT Diabetic kidney disease (DKD) is a leading cause of end‐stage renal disease (ESRD) and is associated with heightened cardiovascular risk and increased overall mortality. Although mesenchymal stem cells (MSCs) have demonstrated therapeutic potential in DKD, their precise mechanisms
Li‐Lan Huang, Yue‐Yuan Hou, Ji Yang, Xing‐Na Liao, Jin‐Sha Ma, Wen‐Chao Wang, Yi‐Xiao Quan, Hong‐Ying Jiang, Yi‐Hua Bai   +8 more
wiley   +1 more source

Prevalence of alkane monooxygenase genes in Arctic and Antarctic hydrocarbon-contaminated and pristine soils [PDF]

, 2017
The prevalence of four alkane monooxygenase genotypes (Pseudomonas putida GPo1, Pp alkB; Rhodococcus sp. strain Q15, Rh alkB1 and Rh alkB2; and Acinetobacter sp.
Greer, C.W., Labbé, D., Luz, A.P., Pellizari, V., Schultz, A., van Beilen, J.B., Whyte, L.G.   +6 more
core  

Engineering von Transmembran‐Alkan‐Monooxygenasen zur Verbesserung des Schlüsselschritts in der Biosynthese des Polymervorläufers Tulipalin A

Angewandte Chemie, Volume 137, Issue 25, June 17, 2025.
Ein Biosyntheseweg für den Polymervorläufer Tulipalin A ausgehend von Isoprenylacetat wird hier präsentiert. Die Alkan‐Monooxygenase AlkB katalysiert die chemo‐ und regioselektive terminale Hydroxylierung von Isoprenylacetat und die Aktivität konnte durch rationelles Engineering des Membranenzyms weiter gesteigert werden. Die vollständige Oxidation zur
Andrea Nigl, Veronica Delsoglio, Lucija Sovic, Marina Grgić, Lenny Malihan‐Yap, Kamela Myrtollari, Jelena Spasic, Margit Winkler, Gustav Oberdorfer, Andreas Taden, Iva Anić, Robert Kourist   +11 more
wiley   +1 more source

Degradation of long-chain n-alkanes in soil microcosms by two actinobacteria [PDF]

, 2012
The ability of two recently isolated actinobacteria, that degrade medium and long chain n-alkanes in laboratory water medium, was investigated in soil microcosms using different standard soils that were artificially contaminated with n-alkanes of ...
DE PASQUALE, Claudio, LO PICCOLO, Luca, PALAZZOLO, Eristanna, QUATRINI, Paola   +3 more
core   +1 more source

Recent Findings in N6‐Methyladenosine Modification and Significance in Pancreatic Cancer

Cancer Medicine, Volume 14, Issue 11, June 2025.
ABSTRACT Background RNA modifications are widely detected in cells and are involved in RNA structural stabilization and regulation of gene expression. In cancer cells, RNA modifications are altered, resulting in abnormal expression of numerous genes and promoting cancer growth. N1‐methyladenosine (m1A), N6‐methyladenosine (m6A), N3‐methylcytosine (m3C),
Tomoaki Hara, Sikun Meng, Yasuko Arao, Yoshiko Saito, Kana Inoue, Sarah Rennie, Ken Ofusa, Toru Kitagawa, Hideshi Ishii   +8 more
wiley   +1 more source

ERCC1-deficient cells and mice are hypersensitive to lipid peroxidation [PDF]

, 2018
Lipid peroxidation (LPO) products are relatively stable and abundant metabolites, which accumulate in tissues of mammals with aging, being able to modify all cellular nucleophiles, creating protein and DNA adducts including crosslinks.
Barańczyk-Kuźma, Anna, Bednarek, Małgorzata, Cieśla, Jarosław M., Czerwińska, Jolanta, Dziuban-Lech, Dorota, Gackowski, Daniel, Gajewska, Beata, Gregg, Siobhán Q., Gurkar, Aditi U., Kosicki, Konrad, Kołata, Daria, McGowan, Sara J., Niedernhofer, Laura J., Nowak, Małgorzata, Oliński, Ryszard, Rigatti, Lora H., Robinson, Andria R., Shane, Hillary L., Speina, Elzbieta, Tudek, Barbara, Wojtczak, Patrycja, Yousefzadeh, Matt J., Zarakowska, Ewelina   +22 more
core   +1 more source