Results 121 to 130 of about 10,817 (260)

M6A Modified miR‐31‐5p Suppresses M1 Macrophage Polarization and Autoimmune Dry Eye by Targeting P2RX7

Advanced Science, Volume 12, Issue 17, May 8, 2025.
The upregulation of FTO in autoimmune dry eye suppresses the recognition of pri‐miR‐31 by DGCR8, thereby inhibiting the maturation of miR‐31‐5p and reducing its inhibitory effect on the target gene P2RX7. The activation of P2RX7 subsequently triggers the p38 MAPK signaling pathway and increases the level of M1‐related genes, thus exacerbating the ...
Lu Zhao, Xuejia Li, Min Gao, Lin Liu, Binyun Ma, Xun Liu, Jiachen Zhang, Ruoxuan Liu, Bei Du, Ruihua Wei, Hong Nian   +10 more
wiley   +1 more source

A real-time PCR-based quantitative assay for 3-methylcytosine demethylase activity of ALKBH3

Biochemistry and Biophysics Reports, 2016
Human AlkB homolog 3 (ALKBH3), a homolog of the Escherichia coli protein AlkB, demethylates 1-methyladenine and 3-methylcytosine (3-meC) in single-stranded DNA and RNA by oxidative demethylation.
Yuko Ueda, Kaori Kitae, Ikumi Ooshio, Yasuyuki Fusamae, Megumi Kawaguchi, Kentaro Jingushi, Kazuo Harada, Kazumasa Hirata, Kazutake Tsujikawa   +8 more
doaj   +1 more source

微生物機能測定手法を利用した熱帯および温帯沿岸生態系管理に関する研究 [PDF]

, 2018
この博士論文は内容の要約のみの公開（または一部非公開）になっています筑波大学 (University of Tsukuba ...
MYAT THWE MYINT AUNG
core   +1 more source

Helicobacter pylori CagA elevates FTO to induce gastric cancer progression via a “hit‐and‐run” paradigm

Cancer Communications, Volume 45, Issue 5, Page 608-631, May 2025.
Abstract Background Helicobacter pylori (H. pylori) infection contributes significantly to gastric cancer (GC) progression. The intrinsic mechanisms of H. pylori‐host interactions and their role in promoting GC progression need further investigation.
Bing He, Yiyang Hu, Yuyun Wu, Chao Wang, Limin Gao, Chunli Gong, Zhibin Li, Nannan Gao, Huan Yang, Yufeng Xiao, Shiming Yang   +10 more
wiley   +1 more source

Diversity of Metabolically Active Bacteria in Water-Flooded High-Temperature Heavy Oil Reservoir

Frontiers in Microbiology, 2017
The goal of this work was to study the overall genomic diversity of microorganisms of the Dagang high-temperature oilfield (PRC) and to characterize the metabolically active fraction of these populations.
Tamara N. Nazina, Natalya M. Shestakova, Ekaterina M. Semenova, Alena V. Korshunova, Nadezda K. Kostrukova, Tatiana P. Tourova, Liu Min, Qingxian Feng, Andrey B. Poltaraus   +8 more
doaj   +1 more source

Electrochemical Characterization of Escherichia coli Adaptive Response Protein AidB [PDF]

, 2012
When exposed to known DNA-damaging alkylating agents, Escherichia coli cells increase production of four DNA repair enzymes: Ada, AlkA, AlkB, and AidB. The role of three enzymes (Ada, AlkA, and AlkB) in repairing DNA lesions has been well characterized ...
Becker, Bowles, Byron, Catherine Drennan, Chohan, Cintyu Wong, Clark, Delaney, Demple, Evensen, Falnes, Falnes, Fink, Frerman, Frick, Ghisla, Hamill, He, Husain, Johnson, Karran, Kim, Landini, Landini, Lenn, Leys, Maier, Marco Jost, Massey, Massey, Massey, Michael Hamill, Mulrooney, Nicholas Bene, Pace, Rippa, Roberts, Roberts, Rohankhedkar, Saenger, Samson, Sean Elliott, Sedgwick, Sedgwick, Sedgwick, Stankovich, Stiehler, Swanson, Toogood, Toogood, Trewick, Vetter, Volkert, Volkert   +53 more
core   +2 more sources

Polymorphisms in the FTO Gene and Their Association With Cancer Risk: A Comprehensive Review and Meta‐Analysis

Cancer Reports, Volume 8, Issue 5, May 2025.
ABSTRACT Background This meta‐analysis aimed to clarify the connection between six polymorphisms in the FTO gene and susceptibility to cancer. Methods The relevant literature on the relationship between FTO variants and cancer susceptibility was comprehensively gathered from PubMed, Scopus, Embase, Medline, and Web of Science prior to May 20, 2024 ...
Fengran Guo, Yilong Gao, Hu Wang, Pengfei Zhou, Yanping Zhang, Zhihai Teng, Yaxuan Wang, Zhenwei Han   +7 more
wiley   +1 more source

Understanding plant-microbe interactions for phytoremediation of petroleum-polluted soil.

PLoS ONE, 2011
Plant-microbe interactions are considered to be important processes determining the efficiency of phytoremediation of petroleum pollution, however relatively little is known about how these interactions are influenced by petroleum pollution.
Ming Nie, Ming Nie, Yijing Wang, Jiayi Yu, Ming Xiao, Lifen Jiang, Ji Yang, Changming Fang, Jiakuan Chen, Bo Li   +9 more
doaj   +1 more source

Effects of changes in intracellular iron pool on AlkB-dependent and AlkB-independent mechanisms protecting E.coli cells against mutagenic action of alkylating agent

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 2015
An Escherichia coli hemH mutant accumulates protoporphyrin IX, causing photosensitivity of cells to visible light. Here, we have shown that intracellular free iron in hemH mutants is double that observed in hemH(+) strain. The aim of this study was to recognize the influence of this increased free iron concentration on AlkB-directed repair of alkylated
Anna Sikora, Katarzyna Pawlak, Małgorzata Dylewska, Jarosław Poznański, Tomasz Pilżys, Elżbieta Grzesiuk, Jan Piwowarski, Michał Marcinkowski, Agnieszka M. Maciejewska, Wioletta Jakubczak   +9 more
openaire   +4 more sources

Identification and use of an alkane transporter plug-in for application in biocatalysis and whole-cell biosensing of alkanes [PDF]

, 2014
Effective application of whole-cell devices in synthetic biology and biocatalysis will always require consideration of the uptake of molecules of interest into the cell.
Baganz, Frank, Dalby, Paul A., Deszcz, Dawid, Folliard, Thomas, Grant, Chris, Martinez-Torres, Rubens Julio, Morris, Phattaraporn, Sreenivasan, Rakesh, Ward, John M., Wei, Yu-Chia, Woodley, John M.   +10 more
core   +2 more sources