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The biological function of demethylase ALKBH1 and its role in human diseases [PDF]
HeliyonAlkB homolog 1 (ALKBH1) is a member of the AlkB family of dioxygenases that are dependent on Fe(II) and α-ketoglutarate. Mounting evidence demonstrates that ALKBH1 exhibits enzymatic activity against various substrates, including N6-methyladenosine (m6A),
Jing Zhong +4 more
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Chinese journal of physiology, 2023 Prostate cancer (PCa) is one of the leading causes of cancer-related death in males worldwide and exploring more reliable biomarkers for PCa is essential for the diagnosis and therapeutics for the disease.
Xun Li +4 more
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Microorganisms, 2023 Rhodococcus sp. strain CH91 is capable of utilizing long-chain n-alkanes as the sole carbon source. Two new genes (alkB1 and alkB2) encoding AlkB-type alkane hydroxylase were predicted by its whole-genome sequence analysis.
Wei Xiang +3 more
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CPA-seq reveals small ncRNAs with methylated nucleosides and diverse termini
Cell Discovery, 2021 High-throughput sequencing reveals the complex landscape of small noncoding RNAs (sRNAs). However, it is limited by requiring 5′-monophosphate and 3′-hydroxyl in RNAs for adapter ligation and hindered by methylated nucleosides that interfere with reverse
Heming Wang +9 more
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Frontiers in Cell and Developmental Biology, 2021 The AlkB family consists of Fe(II)- and α-ketoglutarate-dependent dioxygenases that can catalyze demethylation on a variety of substrates, such as RNA and DNA, subsequently affecting tumor progression and prognosis.
Geting Wu +8 more
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Structure of AlkB–AlkG shows details of alkane terminal C–H selectivity and functionalization
Nature Structural & Molecular Biology, 2023 The cryo-EM structure of a natural AlkB–AlkG fusion from Fontimonas thermophila reveals the mechanistic basis for its selectivity towards, and functionalization of, alkane terminal C–H groups. AlkB contains an alkane entry tunnel and a diiron active site,
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Pseudomonas putida AlkA and AlkB proteins comprise different defense systems for the repair of alkylation damage to DNA - in vivo, in vitro, and in silico studies. [PDF]
PLoS ONE, 2013 Alkylating agents introduce cytotoxic and/or mutagenic lesions to DNA bases leading to induction of adaptive (Ada) response, a mechanism protecting cells against deleterious effects of environmental chemicals.
Damian Mielecki +9 more
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AlkB RNA demethylase homologues and N 6 ‐methyladenosine are involved in Potyvirus infection
Molecular plant pathology, 2022 Proteins of the alkylation B (AlkB) superfamily show RNA demethylase activity removing methyl adducts from N 6‐methyladenosine (m6A). m6A is a reversible epigenetic mark of RNA that regulates human virus replication but has unclear roles in plant virus ...
Jianying Yue +7 more
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Arab Journal of Basic and Applied Sciences, 2023 Thirty-four different soil Streptomyces isolates previously recovered from soils of different gas stations that were historically polluted with fuel oil for long time were analyzed for their ability to produce five different hydrolytic enzymes, as well ...
Ismail Saadoun +5 more
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Frontiers in Plant Science, 2022 The AlkB homologs (ALKBH) gene family regulates N6-methyladenosine (m6A) RNA methylation and is involved in plant growth and the abiotic stress response. Poplar is an important model plant for studying perennial woody plants.
Ye Zhao +10 more
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