Results 41 to 50 of about 10,817 (260)
Viral AlkB proteins repair RNA damage by oxidative demethylation [PDF]
Nucleic Acids Research, 2008 Bacterial and mammalian AlkB proteins are iron(II)- and 2-oxoglutarate-dependent dioxygenases that reverse methylation damage, such as 1-methyladenine and 3-methylcytosine, in RNA and DNA. An AlkB-domain is encoded by the genome of numerous single-stranded, plant-infecting RNA viruses, the majority of which belong to the Flexiviridae family.
Erwin van den Born +6 more
openalex +4 more sources
Microorganisms, 2023 Rhodococcus sp. strain CH91 is capable of utilizing long-chain n-alkanes as the sole carbon source. Two new genes (alkB1 and alkB2) encoding AlkB-type alkane hydroxylase were predicted by its whole-genome sequence analysis.
Wei Xiang +3 more
semanticscholar +1 more source
CPA-seq reveals small ncRNAs with methylated nucleosides and diverse termini
Cell Discovery, 2021 High-throughput sequencing reveals the complex landscape of small noncoding RNAs (sRNAs). However, it is limited by requiring 5′-monophosphate and 3′-hydroxyl in RNAs for adapter ligation and hindered by methylated nucleosides that interfere with reverse
Heming Wang +9 more
doaj +1 more source
Growth of Rhodococcus sp. strain BCP1 on gaseous n-alkanes: New metabolic insights and transcriptional analysis of two soluble di-iron monooxygenase genes [PDF]
, 2015 Rhodococcus sp. strain BCP1 was initially isolated for its ability to grow on gaseous n-alkanes, which act as inducers for the co-metabolic degradation of low-chlorinated compounds.
Cappelletti M. +6 more
core +5 more sources
Frontiers in Cell and Developmental Biology, 2021 The AlkB family consists of Fe(II)- and α-ketoglutarate-dependent dioxygenases that can catalyze demethylation on a variety of substrates, such as RNA and DNA, subsequently affecting tumor progression and prognosis.
Geting Wu +8 more
doaj +1 more source
Structure of AlkB–AlkG shows details of alkane terminal C–H selectivity and functionalization
Nature Structural & Molecular Biology, 2023 The cryo-EM structure of a natural AlkB–AlkG fusion from Fontimonas thermophila reveals the mechanistic basis for its selectivity towards, and functionalization of, alkane terminal C–H groups. AlkB contains an alkane entry tunnel and a diiron active site,
semanticscholar +1 more source
AlkB RNA demethylase homologues and N 6 ‐methyladenosine are involved in Potyvirus infection
Molecular plant pathology, 2022 Proteins of the alkylation B (AlkB) superfamily show RNA demethylase activity removing methyl adducts from N 6‐methyladenosine (m6A). m6A is a reversible epigenetic mark of RNA that regulates human virus replication but has unclear roles in plant virus ...
Jianying Yue +7 more
semanticscholar +1 more source
Pseudomonas putida AlkA and AlkB proteins comprise different defense systems for the repair of alkylation damage to DNA - in vivo, in vitro, and in silico studies. [PDF]
PLoS ONE, 2013 Alkylating agents introduce cytotoxic and/or mutagenic lesions to DNA bases leading to induction of adaptive (Ada) response, a mechanism protecting cells against deleterious effects of environmental chemicals.
Damian Mielecki +9 more
doaj +1 more source
Arab Journal of Basic and Applied Sciences, 2023 Thirty-four different soil Streptomyces isolates previously recovered from soils of different gas stations that were historically polluted with fuel oil for long time were analyzed for their ability to produce five different hydrolytic enzymes, as well ...
Ismail Saadoun +5 more
doaj +1 more source
In Vivo Evolution of Butane Oxidation by Terminal Alkane Hydroxylases AlkB and CYP153A6 [PDF]
, 2009 Enzymes of the AlkB and CYP153 families catalyze the first step in the catabolism of medium-chain-length alkanes, selective oxidation of the alkane to the 1-alkanol, and enable their host organisms to utilize alkanes as carbon sources.
Arnold, Frances H. +3 more
core +3 more sources