Results 51 to 60 of about 10,817 (260)

Contribution of transcription-coupled DNA repair to MMS-induced mutagenesis in E. coli strains deficient in functional AlkB protein. [PDF]

, 2010
In Escherichia coli the alkylating agent methyl methanesulfonate (MMS) induces defense systems (adaptive and SOS responses), DNA repair pathways, and mutagenesis.
Chojnacka, Aleksandra, Grzesiuk, Elzbieta, Kozłowski, Marek, Krwawicz, Joanna, Mielecki, Damian, Nieminuszczy, Jadwiga, Sikora, Anna, Wrzesiński, Michał   +7 more
core   +1 more source

Genome-wide identification of the AlkB homologs gene family, PagALKBH9B and PagALKBH10B regulated salt stress response in Populus

Frontiers in Plant Science, 2022
The AlkB homologs (ALKBH) gene family regulates N6-methyladenosine (m6A) RNA methylation and is involved in plant growth and the abiotic stress response. Poplar is an important model plant for studying perennial woody plants.
Ye Zhao, Qi Guo, Sen Cao, Yanting Tian, K. Han, Yuhan Sun, Juan Li, Qingshan Yang, Qingju Ji, R. Sederoff, Yun Li   +10 more
semanticscholar   +1 more source

Structural and mechanistic studies of AlkB

The FASEB Journal, 2008
Recently, there has been rapid progress in understanding the molecular functions of DNA repair enzymes in the AlkB superfamily, which are present in many eubacteria and all higher eukaryotes. These enzymes have been demonstrated to catalyze direct repair of adenine and cytosine bases that have been alkylated on endocyclic nitrogen atoms, a toxic DNA ...
Ramy Farid, Richard A. Friesner, John F. Hunt, Bomina Yu, Brian R. Gibney, Gregory Liebisch, William Edstrom, Chiara Pastore, Burce Ergel   +8 more
openaire   +1 more source

Case Report: Biallelic Variant in the tRNA Methyltransferase Domain of the AlkB Homolog 8 Causes Syndromic Intellectual Disability

Frontiers in Genetics, 2022
Intellectual disability (ID) has become very common and is an extremely heterogeneous disorder, where the patients face many challenges with deficits in intellectual functioning and adaptive behaviors.
Ahmed Waqas, A. Nayab, Shabnam Shaheen, S. Abbas, Muhammad Latif, M. Rafeeq, I. Al-Dhuayan, A. Alqosaibi, M. M. Alnamshan, Ziaullah M. Sain, A. H. Habib, Q. Alam, Muhammad Umair, M. Saqib   +13 more
semanticscholar   +1 more source

Adaptive Response Enzyme AlkB Preferentially Repairs 1-Methylguanine and 3-Methylthymine Adducts in Double-Stranded DNA [PDF]

, 2018
The AlkB protein is a repair enzyme that uses an α-ketoglutarate/Fe(II)-dependent mechanism to repair alkyl DNA adducts. AlkB has been reported to repair highly susceptible substrates, such as 1-methyladenine and 3-methylcytosine, more efficiently in ss ...
Bian, Ke, Chen, Fangyi, Drennan, Catherine L., Essigmann, John M, Humulock, Zachary T., Jost, Marco, Li, Deyu, Tang, Qi, Yang, Xuedong   +8 more
core   +1 more source

Electrochemical Hydroxylation of C3–C12 n-Alkanes by Recombinant Alkane Hydroxylase (AlkB) and Rubredoxin-2 (AlkG) from Pseudomonas putida GPo1

Scientific Reports, 2017
An unprecedented method for the efficient conversion of C3–C12 linear alkanes to their corresponding primary alcohols mediated by the membrane-bound alkane hydroxylase (AlkB) from Pseudomonas putida GPo1 is demonstrated. The X-ray absorption spectroscopy
Yi-Fang Tsai, Wen-I Luo, Jen-Lin Chang, Chun-Wei Chang, Huai-Chun Chuang, Ravirala Ramu, Guor-Tzo Wei, Jyh-Myng Zen, Steve S.-F. Yu   +8 more
doaj   +1 more source

The alkane 1-monooxigenase gene alkB of Pseudomonas sp. FF2 is upregulated during colonisation of Arabidopsis thaliana leaves

bioRxiv
Bacteria on leaf surfaces encounter highly variable access to nutrients and water. This oligotrophic environment is partly due to the presence of cuticular waxes that render the leaf surface hydrophobic, reducing the leaching of nutrients and water loss ...
R. Schlechter, Laura Voss, Evan J. Kear, Mila Oeltjen, Mitja N. P. Remus‐Emsermann   +4 more
openalex   +2 more sources

The AlkB Family of Fe(II)/α-Ketoglutarate-dependent Dioxygenases: Repairing Nucleic Acid Alkylation Damage and Beyond [PDF]

, 2015
The AlkB family of Fe(II)- and α-ketoglutarate-dependent dioxygenases is a class of ubiquitous direct reversal DNA repair enzymes that remove alkyl adducts from nucleobases by oxidative dealkylation.
Delaney, James C., Essigmann, John M., Fedeles, Bogdan I., Li, Deyu, Singh, Vipender   +4 more
core   +1 more source

M. tuberculosis AlkX Encoded by rv3249c Regulates a Conserved Alkane Hydroxylase System That Is Important for Replication in Macrophages and Biofilm Formation

Microbiology Spectrum, 2022
Mycobacterium tuberculosis is a highly specialized human pathogen. The success of M. tuberculosis is due to its ability to replicate within host macrophages, resist host immune responses, and ultimately enter a persistent state during a latent ...
Haley Stokas, Heather L. Rhodes, Marit B. Simmons, Richard Zhang, Catherine C. Wright, Georgiana E. Purdy   +5 more
doaj   +1 more source

1,N 6 -α-hydroxypropanoadenine, the acrolein adduct to adenine, is a substrate for AlkB dioxygenase [PDF]

, 2017
1,N6-α-hydroxypropanoadenine (HPA) is an exocyclic DNA adduct of acrolein – an environmental pollutant and endocellular oxidative stress product. Escherichia coli AlkB dioxygenase belongs to the superfamily of α-ketoglutarate (αKG)- and iron-dependent ...
Dylewska, Małgorzata, Kusmierek, Jaroslaw T., Maciejewska, Agnieszka M., Pilżys, Tomasz, Poznański, Jarosław   +4 more
core   +1 more source