Results 61 to 70 of about 6,739 (216)

The Shu complex prevents mutagenesis and cytotoxicity of single-strand specific alkylation lesions

eLife, 2021
Three-methyl cytosine (3meC) are toxic DNA lesions, blocking base pairing. Bacteria and humans express members of the AlkB enzymes family, which directly remove 3meC. However, other organisms, including budding yeast, lack this class of enzymes.
Braulio Bonilla, Alexander J Brown, Sarah R Hengel, Kyle S Rapchak, Debra Mitchell, Catherine A Pressimone, Adeola A Fagunloye, Thong T Luong, Reagan A Russell, Rudri K Vyas, Tony M Mertz, Hani S Zaher, Nima Mosammaparast, Ewa P Malc, Piotr A Mieczkowski, Steven A Roberts, Kara A Bernstein   +16 more
doaj   +1 more source

Plant n-alkane production from litterfall altered the diversity and community structure of alkane degrading bacteria in litter layer in lowland subtropical rainforest in Taiwan [PDF]

Biogeosciences, 2018
n-Alkane and alkane-degrading bacteria have long been used as crucial biological indicators of paleoecology, petroleum pollution, and oil and gas prospecting.
T.-Y. Huang, T.-Y. Huang, B.-M. Hsu, B.-M. Hsu, W.-C. Chao, C.-W. Fan   +5 more
doaj   +1 more source

Suppression of Escherichia coli alkB mutants by Saccharomyces cerevisiae genes [PDF]

Journal of Bacteriology, 1995
The alkB gene is one of a group of alkylation-inducible genes in Escherichia coli, and its product protects cells from SN2-type alkylating agents such as methyl methanesulfonate (MMS). However, the precise biochemical function of the AlkB protein remains unknown.
Ying-Fei Wei, Leona D. Samson, Beiru Jia Chen   +2 more
openaire   +3 more sources

Alkane Hydroxylase Gene (alkB) Phylotype Composition and Diversity in Northern Gulf of Mexico Bacterioplankton

Frontiers in Microbiology, 2013
Natural and anthropogenic activities introduce alkanes into marine systems where they are degraded by alkane hydroxylases expressed by phylogenetically diverse bacteria. Partial sequences for alkB, one of the structural genes of alkane hydroxylase, have
Conor Blake Smith, Bradley B Tolar, James T Hollibaugh, Gary M King   +3 more
doaj   +1 more source

Distribution of alkB genes within n-alkane-degrading bacteria [PDF]

Journal of Applied Microbiology, 2000
Fifty-four bacterial strains belonging to 37 species were tested for their ability to assimilate short chain and/or medium chain liquid n-alkanes. A gene probe derived from the alkB gene of Pseudomonas oleovorans ATCC 29347 was utilized in hybridization experiments.
A. Vomberg, U. Klinner
openaire   +3 more sources

Human ALKBH6 Is Required for Maintenance of Genomic Stability and Promoting Cell Survival During Exposure of Alkylating Agents in Pancreatic Cancer

Frontiers in Genetics, 2021
Alpha-ketoglutarate-dependent dioxygenase (ALKBH) is a DNA repair gene involved in the repair of alkylating DNA damage. There are nine types of ALKBH (ALKBH1-8 and FTO) identified in humans.
Shengyuan Zhao, Rodan Devega, Aaliyah Francois, Dawit Kidane   +3 more
doaj   +1 more source

m6A‐Mediated TMCO3 Promotes Hepatocellular Carcinoma Progression by Facilitating the Membrane Translocation and Activation of AKT

Advanced Science, EarlyView.
TMCO3 as a downstream target of ALKBH5 is found, which regulates its expression in an m6A‐dependent manner, and then a new phosphorylation site on TMCO3 is identified and determines the specific mechanism of TMCO3 with AKT. Moreover, the combined treatment of targeting the TMCO3 and inhibition of AKT in mice models with HCC achieves great results ...
Xinxin Li, Mengzhen Han, He Zhu, Yonglong Pan, Chen Su, Yachong Liu, Zhibin Liao, Bixiang Zhang, Xiaoping Chen   +8 more
wiley   +1 more source

Repair of DNA Alkylation Damage by the Escherichia coli Adaptive Response Protein AlkB as Studied by ESI-TOF Mass Spectrometry

Journal of Nucleic Acids, 2010
DNA alkylation can cause mutations, epigenetic changes, and even cell death. All living organisms have evolved enzymatic and non-enzymatic strategies for repairing such alkylation damage.
Deyu Li, James C. Delaney, Charlotte M. Page, Alvin S. Chen, Cintyu Wong, Catherine L. Drennan, John M. Essigmann   +6 more
doaj   +1 more source

Phylogenomic identification of five new human homologs of the DNA repair enzyme AlkB

BMC Genomics, 2003
Background Combination of biochemical and bioinformatic analyses led to the discovery of oxidative demethylation – a novel DNA repair mechanism catalyzed by the Escherichia coli AlkB protein and its two human homologs, hABH2 and hABH3. This discovery was
Papaj Grzegorz, Bhagwat Ashok S, Kurowski Michal A, Bujnicki Janusz M   +3 more
doaj   +1 more source

MdDSK2a‐Like‐MdMTA Module Functions in Apple Cold Response via Regulating ROS Detoxification and Cell Wall Deposition

Advanced Science, EarlyView.
Under cold stress, MdDSK2a‐like is degraded via the 26S proteasome pathway, thereby alleviating the degradation of MdMTA induced by the 26S proteasome and autophagy pathways mediated by MdDSK2a‐like. The accumulated MdMTA increases the m6A levels of cold‐responsive genes, thereby contributing to increased ROS detoxification, deposition of cell wall, as
Nan Hou, Jieqiang He, Chana Bao, Fang Zhi, Xiaoxia Shen, Yu Liu, Chaoshuo Li, Tianle Fan, Xinyue Yang, Baohua Chu, Gege Qin, Zeyuan Liu, Chuang Mei, Bin Tan, Jiancan Feng, Fengwang Ma, Mickael Malnoy, Xuewei Li, Qingmei Guan   +18 more
wiley   +1 more source