Results 81 to 90 of about 6,739 (216)

tRF‐3a‐Pro: A Transfer RNA‐Derived Small RNA as a Novel Biomarker for Diagnosis of Hepatitis B Virus‐Related Hepatocellular Carcinoma

Cell Proliferation, EarlyView.
tRF‐3a is the main tsRNA subtype up‐regulated in HBV‐related HCC. tRF‐3a‐Pro is significantly up‐regulated in HBV‐related HCC tumour than that in paratumour tissues. The level of tRF‐3a‐Pro in serum is a promising candidate biomarker for HCC diagnosis. tRF‐3a‐Pro promotes cell proliferation and regulates cell cycle of HCC.
Jingyi Si, Yanting Zou, Yifan Gao, Jia Chen, Wei Jiang, Xizhong Shen, Changfeng Zhu, Qunyan Yao   +7 more
wiley   +1 more source

Diversity and abundance of n-alkane-degrading bacteria in the near-surface soils of a Chinese onshore oil and gas field [PDF]

Biogeosciences, 2013
Alkane-degrading bacteria have long been used as an important biological indicator for oil and gas prospecting, but their ecological characteristics in hydrocarbon microseep habitats are still poorly understood. In this study, the diversity and abundance
K. Xu, Y. Tang, C. Ren, K. Zhao, Y. Sun
doaj   +1 more source

Inhibition of Alkbh5 Attenuates Lipopolysaccharide‐Induced Lung Injury by Promoting Ccl1 m6A and Treg Recruitment

Cell Proliferation, EarlyView.
In septic lung injury mice, Alkbh5 is highly expressed, promoting the demethylation of m6A on Ccl1 mRNA, thereby reducing the stability of Ccl1 mRNA and decreasing Ccl1 expression. This, in turn, leads to reduced recruitment of Tregs, further exacerbating the symptoms of septic lung injury.
Hongdou Ding, Xinnan Xu, Yaoyao Zhu, Xinyu Ling, Li Xu   +4 more
wiley   +1 more source

Conformational and Mechanistic Studies of AlkB and AlkBH2 DNA Demethylases

The FASEB Journal, 2019
DNA demethylases play a crucial role in DNA repair mechanisms and have been linked to pathologies. AlkB enzyme and its human homolog AlkBH2 have been very intensively studied both experimentally and computationally. It is well known also that AlkB exhibits broader substrate specificity than AlkBH2.
Tatyana G. Karabencheva-Christova, Christo Z. Christov, Rajeev Ramanan, Shobhit S. Chaturvedi, Sodic Waheed   +4 more
openaire   +2 more sources

The m6A demethylase FTO promotes C/EBPβ‐LIP translation to perform oncogenic functions in breast cancer cells

The FEBS Journal, EarlyView.
N6‐methyladenosine is a key mRNA modification that regulates transcript turnover, translation, and other aspects of RNA fate. The m6A‐demethylase ‘eraser’ enzyme FTO reverses this modification. While FTO is known to promote oncogenic signaling in triple‐negative breast cancer, its wider role across the genome and specific downstream signaling has yet ...
Hidde R. Zuidhof, Christine Müller, Gertrud Kortman, René Wardenaar, Ekaterina Stepanova, Fabricio Loayza‐Puch, Cornelis F. Calkhoven   +6 more
wiley   +1 more source

Unique starch biosynthesis pathways in wild rice revealed by multi‐omics analyses

Plant Biotechnology Journal, EarlyView.
Summary Australian wild rice species (AWS) possess unique starch properties characterized by a slow digestibility rate. However, the genomic and transcriptomic variations of starch‐synthesis‐related genes (SSRGs) influencing starch physiochemical properties in AWS remain unclear.
Nurmansyah, Agnelo Furtado, Pauline Okemo, Robert J. Henry   +3 more
wiley   +1 more source

FoxO1 Deficiency in Monocytic Myeloid‐Derived Suppressor Cells Exacerbates B Cell Dysfunction in Systemic Lupus Erythematosus

Arthritis &Rheumatology, Volume 77, Issue 4, Page 423-438, April 2025.
Objective Myeloid‐derived suppressor cells (MDSCs) contribute to the pathogenesis of systemic lupus erythematosus (SLE), in part due to promoting the survival of plasma cells. FoxO1 expression in monocytic MDSCs (M‐MDSCs) exhibits a negative correlation with the SLE Disease Activity Index score.
Liping Tan, Wei Kong, Kangxing Zhou, Shuangan Wang, Jun Liang, Yayi Hou, Huan Dou   +6 more
wiley   +1 more source

Probe Capture Enrichment Sequencing of amoA Genes Improves the Detection of Diverse Ammonia‐Oxidising Archaeal and Bacterial Populations

Molecular Ecology Resources, Volume 25, Issue 3, April 2025.
ABSTRACT The ammonia monooxygenase subunit A (amoA) gene has been used to investigate the phylogenetic diversity, spatial distribution and activity of ammonia‐oxidising archaeal (AOA) and bacterial (AOB), which contribute significantly to the nitrogen cycle in various ecosystems. Amplicon sequencing of amoA is a widely used method; however, it produces
Satoshi Hiraoka, Minoru Ijichi, Hirohiko Takeshima, Yohei Kumagai, Ching‐Chia Yang, Yoko Makabe‐Kobayashi, Hideki Fukuda, Susumu Yoshizawa, Wataru Iwasaki, Kazuhiro Kogure, Takuhei Shiozaki   +10 more
wiley   +1 more source

AlkB Homologue 2–Mediated Repair of Ethenoadenine Lesions in Mammalian DNA [PDF]

Cancer Research, 2008
Abstract Endogenous formation of the mutagenic DNA adduct 1,N6-ethenoadenine (εA) originates from lipid peroxidation. Elevated levels of εA in cancer-prone tissues suggest a role for this adduct in the development of some cancers. The base excision repair pathway has been considered the principal repair system for εA lesions until ...
Ringvoll, J, Moen, MN, Nordstrand, LM, Meira, LB, Pang, B, Bekkelund, A, Dedon, PC, Bjelland, S, Samson, LD, Falnes, PO, Klungland, A   +10 more
openaire   +4 more sources

A real-time PCR-based quantitative assay for 3-methylcytosine demethylase activity of ALKBH3

Biochemistry and Biophysics Reports, 2016
Human AlkB homolog 3 (ALKBH3), a homolog of the Escherichia coli protein AlkB, demethylates 1-methyladenine and 3-methylcytosine (3-meC) in single-stranded DNA and RNA by oxidative demethylation.
Yuko Ueda, Kaori Kitae, Ikumi Ooshio, Yasuyuki Fusamae, Megumi Kawaguchi, Kentaro Jingushi, Kazuo Harada, Kazumasa Hirata, Kazutake Tsujikawa   +8 more
doaj   +1 more source