Electrochemical Characterization of Escherichia coli Adaptive Response Protein AidB [PDF]
, 2012 When exposed to known DNA-damaging alkylating agents, Escherichia coli cells increase production of four DNA repair enzymes: Ada, AlkA, AlkB, and AidB. The role of three enzymes (Ada, AlkA, and AlkB) in repairing DNA lesions has been well characterized ...
Becker +53 more
core +2 more sources
Dynamic states of the DNA repair enzyme AlkB regulate product release [PDF]
EMBO reports, 2008 The 2‐oxoglutarate (2OG)‐ and Fe2+‐dependent dioxygenase AlkB couples the demethylation of modified DNA to the decarboxylation of 2OG. Extensive crystallographic analyses have shown no evidence of significant structural differences between complexes binding either 2OG or succinate.
Bleijlevens, B +8 more
openaire +3 more sources
RNA‐Binding Proteins and Ferroptosis in Cancer: Mechanism and Therapeutic Implications
MedComm – Oncology, Volume 5, Issue 1, March 2026.Ferroptosis critically influences cancer cell fate and represents a promising therapeutic strategy. Emerging evidence identifies RNA‐binding proteins (RBPs) as key post‐transcriptional regulators of ferroptosis. The figure summarizes ferroptosis‐related RBPs across cancers: blue RBPs act as tumor suppressors by promoting ferroptosis, whereas red RBPs ...
Linlin Chang +6 more
wiley +1 more source
Mechanism of Repair of Acrolein- and Malondialdehyde-Derived Exocyclic Guanine Adducts by the α-Ketoglutarate/Fe(II) Dioxygenase AlkB [PDF]
, 2014 The structurally related exocyclic guanine adducts α-hydroxypropano-dG (α-OH-PdG), γ-hydroxypropano-dG (γ-OH-PdG), and M[subscript 1]dG are formed when DNA is exposed to the reactive aldehydes acrolein and malondialdehyde (MDA).
Delaney, James C. +8 more
core +3 more sources
Repair of Methylation Damage in DNA and RNA by Mammalian AlkB Homologues [PDF]
Journal of Biological Chemistry, 2005 Human and Escherichia coli derivatives of AlkB enzymes remove methyl groups from 1-methyladenine and 3-methylcytosine in nucleic acids via an oxidative mechanism that releases the methyl group as formaldehyde. In this report, we demonstrate that the mouse homologues of the alpha-ketoglutarate Fe(II) oxygen-dependent enzymes mAbh2 and Abh3 have ...
Lee, Dong-Hyun +5 more
openaire +4 more sources
Peripheral Nerves in Cancer: Regulatory Roles and Therapeutic Strategies
MedComm, Volume 7, Issue 2, February 2026.The interaction between cancer cells and peripheral nerves: (1) tumor cells could induce the growth of new neural axons and constructing a neural fiber network within the tumor tissue through secreting nerve growth factors; (2) nerve‐derived bioactive molecules can induce perineural invasion of tumor and regulate the malignant phenotype of tumor, such ...
Yan Fu +6 more
wiley +1 more source
Alkbh8 Regulates Selenocysteine-Protein Expression to Protect against Reactive Oxygen Species Damage [PDF]
, 2015 Environmental and metabolic sources of reactive oxygen species (ROS) can damage DNA, proteins and lipids to promote disease. Regulation of gene expression can prevent this damage and can include increased transcription, translation and post translational
Begley, Thomas J. +8 more
core +3 more sources
Analyses of both the alkB Gene Transcriptional Start Site and alkB Promoter-Inducing Properties of Rhodococcus sp. Strain BCP1 Grown on n -Alkanes [PDF]
Applied and Environmental Microbiology, 2011 ABSTRACT Rhodococcus sp. strain BCP1, known for its capacity to grow on short-chain n -alkanes (C 2 to C 7 ) and to cometabolize chlorinated solvents, was found to also utilize medium- and long-chain n -alkanes (C
CAPPELLETTI, MARTINA +5 more
openaire +2 more sources
Role of the Demethylase AlkB Homolog H5 in the Promotion of Dentinogenesis
Frontiers in Physiology, 2022 Dentinogenesis is a key process in tooth formation and is regulated by a series of pre- and post-transcriptional regulations. N6-methyl-adenosine (m6A), which is the most prevalent internal chemical modification that can be removed by the RNA demethylase AlkB homolog H5 (ALKBH5), has recently been reported to be involved in several biological processes.
Cheng Tian +12 more
openaire +3 more sources
Environmental Microbiology Reports, Volume 18, Issue 1, February 2026.The Antarctic Dietzia and Pusillimonas isolates were tested for bioremediation applications. Genomic analyses revealed the potential to degrade complex organic compounds, potential virulence factors and resistance genes. Physiological assays showed a wide range of adaptation to abiotic factors and sensitivity to different groups of antibiotics ...
Tomasz Krucoń +4 more
wiley +1 more source