Results 1 to 10 of about 110,088 (171)

The role of demethylase AlkB homologs in cancer [PDF]

Frontiers in Oncology, 2023
The AlkB family (ALKBH1-8 and FTO), a member of the Fe (II)- and α-ketoglutarate-dependent dioxygenase superfamily, has shown the ability to catalyze the demethylation of a variety of substrates, including DNA, RNA, and histones.
Qiao Li, Qiao Li, Qingsan Zhu
doaj   +7 more sources

Genome-wide identification of the AlkB homologs gene family, PagALKBH9B and PagALKBH10B regulated salt stress response in Populus [PDF]

Frontiers in Plant Science, 2022
The AlkB homologs (ALKBH) gene family regulates N6-methyladenosine (m6A) RNA methylation and is involved in plant growth and the abiotic stress response. Poplar is an important model plant for studying perennial woody plants.
Ye Zhao, Qi Guo, Sen Cao, Yanting Tian, Kunjin Han, Yuhan Sun, Juan Li, Qingshan Yang, Qingju Ji, Ronald Sederoff, Yun Li   +10 more
doaj   +7 more sources

Phylogenomic identification of five new human homologs of the DNA repair enzyme AlkB [PDF]

BMC Genomics, 2003
Background Combination of biochemical and bioinformatic analyses led to the discovery of oxidative demethylation – a novel DNA repair mechanism catalyzed by the Escherichia coli AlkB protein and its two human homologs, hABH2 and hABH3. This discovery was
Papaj Grzegorz, Bhagwat Ashok S, Kurowski Michal A, Bujnicki Janusz M   +3 more
doaj   +7 more sources

The AlkB Homolog SlALKBH10B Negatively Affects Drought and Salt Tolerance in Solanum lycopersicum. [PDF]

Int J Mol Sci, 2023
ALKBH proteins, the homologs of Escherichia coli AlkB dioxygenase, constitute a single-protein repair system that safeguards cellular DNA and RNA against the harmful effects of alkylating agents. ALKBH10B, the first discovered N6-methyladenosine (m6A) demethylase in Arabidopsis (Arabidopsis thaliana), has been shown to regulate plant growth ...
Shen H, Zhou Y, Liao C, Xie Q, Chen G, Hu Z, Wu T.   +6 more
europepmc   +6 more sources

Non-homologous functions of the AlkB homologs [PDF]

Journal of Molecular Cell Biology, 2015
The DNA repair enzyme AlkB was identified in E. coli more than three decades ago. Since then, nine mammalian homologs, all members of the superfamily of alpha-ketoglutarate and Fe(II)-dependent dioxygenases, have been identified (designated ALKBH1-8 and FTO). While E.
Rune Ougland, Torbjørn Rognes, Arne Klungland, Elisabeth Larsen   +3 more
semanticscholar   +5 more sources

Kinetic Studies on the 2-Oxoglutarate/Fe(II)-Dependent Nucleic Acid Modifying Enzymes from the AlkB and TET Families [PDF]

DNA, 2023
Nucleic acid methylations are important genetic and epigenetic biomarkers. The formation and removal of these markers is related to either methylation or demethylation.
Zhiyuan Peng, Jian Ma, Christo Z. Christov, Tatyana Karabencheva-Christova, Nicolai Lehnert, Deyu Li   +5 more
doaj   +3 more sources

Therapeutic potential of ALKB homologs for cardiovascular disease

Biomedicine & Pharmacotherapy, 2020
Cardiovascular diseases (CVDs) are the leading causes of human death. Recently, ALKB homologs, including ALKBH1-8 and FTO, have been found to have a variety of biological functions, such as histone demethylation, RNA demethylation, and DNA demethylation.
Mingzhu Xiao, Jiaming Liu, Cui-Ling Xian, Keng-Yu Chen, Zhongqiu Liu, Yuanyuan Cheng   +5 more
semanticscholar   +5 more sources

Dealkylation of Macromolecules by Eukaryotic α-Ketoglutarate-Dependent Dioxygenases from the AlkB-like Family [PDF]

Current Issues in Molecular Biology
Alkylating modifications induced by either exogenous chemical agents or endogenous metabolites are some of the main types of damage to DNA, RNA, and proteins in the cell.
Anastasiia T. Davletgildeeva, Nikita A. Kuznetsov   +1 more
doaj   +3 more sources

Genome-wide identification and characterization of ALKB homolog gene family in wheat (Triticum aestivum L.) [PDF]

Frontiers in Plant Science
IntroductionN6-methyladenosine (m6A) is the most prevalent posttranscriptional modification in eukaryotic mRNAs. AlkB homologs (ALKBHs) are involved in plant responses to stress by modulating m6A methylation.
Pengkun Wang, Tianye Zhang, Zechi Wu, Lei Yu, Pingan Liao, Jian Yang, Bingjian Sun   +6 more
doaj   +4 more sources

Human AlkB Homolog 1 Is a Mitochondrial Protein That Demethylates 3-Methylcytosine in DNA and RNA [PDF]

Journal of Biological Chemistry, 2008
The Escherichia coli AlkB protein and human homologs hABH2 and hABH3 are 2-oxoglutarate (2OG)/Fe(II)-dependent DNA/RNA demethylases that repair 1-methyladenine and 3-methylcytosine residues. Surprisingly, hABH1, which displays the strongest homology to AlkB, failed to show repair activity in two independent studies.
Marianne P. Westbye, Emadoldin Feyzi, Per Arne, Cathrine Broberg Vågbø, Vivi Talstad, Bodil Kavli, Lars Hagen, Ottar Sundheim, Mansour Akbari, Nina‐Beate Liabakk, Geir Slupphaug, Marit Otterlei, Hans E. Krokan   +12 more
semanticscholar   +6 more sources