The role of demethylase AlkB homologs in cancer [PDF]
Frontiers in Oncology, 2023 The AlkB family (ALKBH1-8 and FTO), a member of the Fe (II)- and α-ketoglutarate-dependent dioxygenase superfamily, has shown the ability to catalyze the demethylation of a variety of substrates, including DNA, RNA, and histones.
Qiao Li, Qiao Li, Qingsan Zhu
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Genome-wide identification of the AlkB homologs gene family, PagALKBH9B and PagALKBH10B regulated salt stress response in Populus [PDF]
Frontiers in Plant Science, 2022 The AlkB homologs (ALKBH) gene family regulates N6-methyladenosine (m6A) RNA methylation and is involved in plant growth and the abiotic stress response. Poplar is an important model plant for studying perennial woody plants.
Ye Zhao +10 more
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Human AlkB Homolog ABH8 Is a tRNA Methyltransferase Required for Wobble Uridine Modification and DNA Damage Survival [PDF]
Molecular and Cellular Biology, 2010 tRNA nucleosides are extensively modified to ensure their proper function in translation. However, many of the enzymes responsible for tRNA modifications in mammals await identification.
Tsz Yan Clement Chan +2 more
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Phylogenomic identification of five new human homologs of the DNA repair enzyme AlkB [PDF]
BMC Genomics, 2003 Background Combination of biochemical and bioinformatic analyses led to the discovery of oxidative demethylation – a novel DNA repair mechanism catalyzed by the Escherichia coli AlkB protein and its two human homologs, hABH2 and hABH3. This discovery was
Papaj Grzegorz +3 more
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Genome-wide identification and characterization of ALKB homolog gene family in wheat (Triticum aestivum L.) [PDF]
Frontiers in Plant ScienceIntroductionN6-methyladenosine (m6A) is the most prevalent posttranscriptional modification in eukaryotic mRNAs. AlkB homologs (ALKBHs) are involved in plant responses to stress by modulating m6A methylation.
Pengkun Wang +6 more
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Human ALKBH4 interacts with proteins associated with transcription. [PDF]
PLoS ONE, 2012 The Fe(II)- and 2-oxoglutarate (2OG)-dependent dioxygenase AlkB from E. coli is a demethylase which repairs alkyl lesions in DNA, as well as RNA, through a direct reversal mechanism. Humans possess nine AlkB homologs (ALKBH1-8 and FTO). ALKBH2 and ALKBH3
Linn G Bjørnstad +5 more
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Novel AlkB dioxygenases--alternative models for in silico and in vivo studies. [PDF]
PLoS ONE, 2012 BackgroundALKBH proteins, the homologs of Escherichia coli AlkB dioxygenase, constitute a direct, single-protein repair system, protecting cellular DNA and RNA against the cytotoxic and mutagenic activity of alkylating agents, chemicals significantly ...
Damian Mielecki +8 more
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Dealkylation of Macromolecules by Eukaryotic α-Ketoglutarate-Dependent Dioxygenases from the AlkB-like Family [PDF]
Current Issues in Molecular BiologyAlkylating modifications induced by either exogenous chemical agents or endogenous metabolites are some of the main types of damage to DNA, RNA, and proteins in the cell.
Anastasiia T. Davletgildeeva +1 more
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Can flavoprotein monooxygenases functionalize long-chain n-alkanes? [PDF]
PLoS ONELong-chain n-alkane functionalization is relevant for industrial and environmental applications, but it remains a significant challenge due to the inherent stability of their covalent bonds. Biocatalytic approaches offer promising strategies due to their
Raul Mireles +3 more
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Schizosaccharomyces pombe Ofd2 is a nuclear 2-oxoglutarate and iron dependent dioxygenase interacting with histones. [PDF]
PLoS ONE, 2011 2-Oxoglutarate (2OG) dependent dioxygenases are ubiquitous iron containing enzymes that couple substrate oxidation to the conversion of 2OG to succinate and carbon dioxide.
Hanne Korvald +6 more
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