The role of demethylase AlkB homologs in cancer [PDF]
Frontiers in Oncology, 2023 The AlkB family (ALKBH1-8 and FTO), a member of the Fe (II)- and α-ketoglutarate-dependent dioxygenase superfamily, has shown the ability to catalyze the demethylation of a variety of substrates, including DNA, RNA, and histones.
Qiao Li, Qiao Li, Qingsan Zhu
doaj +5 more sources
Genome-wide identification of the AlkB homologs gene family, PagALKBH9B and PagALKBH10B regulated salt stress response in Populus [PDF]
Frontiers in Plant Science, 2022 The AlkB homologs (ALKBH) gene family regulates N6-methyladenosine (m6A) RNA methylation and is involved in plant growth and the abiotic stress response. Poplar is an important model plant for studying perennial woody plants.
Ye Zhao +10 more
doaj +5 more sources
The AlkB Homolog SlALKBH10B Negatively Affects Drought and Salt Tolerance in Solanum lycopersicum. [PDF]
Int J Mol Sci, 2023 ALKBH proteins, the homologs of Escherichia coli AlkB dioxygenase, constitute a single-protein repair system that safeguards cellular DNA and RNA against the harmful effects of alkylating agents.
Shen H +6 more
europepmc +4 more sources
Dealkylation of Macromolecules by Eukaryotic α-Ketoglutarate-Dependent Dioxygenases from the AlkB-like Family [PDF]
Current Issues in Molecular BiologyAlkylating modifications induced by either exogenous chemical agents or endogenous metabolites are some of the main types of damage to DNA, RNA, and proteins in the cell.
Anastasiia T. Davletgildeeva +1 more
doaj +3 more sources
Phylogenomic identification of five new human homologs of the DNA repair enzyme AlkB [PDF]
BMC Genomics, 2003 Background Combination of biochemical and bioinformatic analyses led to the discovery of oxidative demethylation – a novel DNA repair mechanism catalyzed by the Escherichia coli AlkB protein and its two human homologs, hABH2 and hABH3. This discovery was
Papaj Grzegorz +3 more
doaj +4 more sources
Can flavoprotein monooxygenases functionalize long-chain n-alkanes? [PDF]
PLoS ONELong-chain n-alkane functionalization is relevant for industrial and environmental applications, but it remains a significant challenge due to the inherent stability of their covalent bonds. Biocatalytic approaches offer promising strategies due to their
Raul Mireles +3 more
doaj +3 more sources
DNA, 2023 Nucleic acid methylations are important genetic and epigenetic biomarkers. The formation and removal of these markers is related to either methylation or demethylation.
Zhiyuan Peng +5 more
doaj +2 more sources
Generalization of Classification of AlkB Family Alkane Monooxygenases from <i>Rhodococcus</i> (<i>sensu lato</i>) Group Based on Phylogenetic Analysis and Genomic Context Comparison. [PDF]
Int J Mol SciAlkane-oxidizing bacteria play a crucial role in the global carbon cycle. Rhodococcus species are well-known hydrocarbon degraders, distinguished by the harboring of multiple homologs of AlkB family alkane monooxygenases.
Petrikov KV +4 more
europepmc +2 more sources
Novel AlkB dioxygenases--alternative models for in silico and in vivo studies.
PLoS ONE, 2012 BackgroundALKBH proteins, the homologs of Escherichia coli AlkB dioxygenase, constitute a direct, single-protein repair system, protecting cellular DNA and RNA against the cytotoxic and mutagenic activity of alkylating agents, chemicals significantly ...
Damian Mielecki +8 more
doaj +2 more sources
Genome mining and screening for plastic-degrading potential in marine bacteria [PDF]
Applied Microbiology and BiotechnologyMarine plastic litter, including microplastics, has a profound impact on the ocean and its wildlife, and strategies to remove/eliminate it are needed. Microbial biodegradation, particularly by bacteria, offers a potential solution, where a link between ...
Rafaela Perdigão +5 more
doaj +2 more sources