Results 151 to 160 of about 110,088 (171)

Sirtuin4 impacts mitochondrial homeostasis in pancreatic cancer cells by reducing the stability of AlkB homolog 1 via deacetylation of the HRD1-SEL1L complex

Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 2023
Pancreatic ductal adenocarcinoma (PDAC) is a highly malignant tumor with a poor prognosis. As a tumor inhibitor, the specific tumor suppressor mechanism of Sirtuin4(SIRT4) in PDAC remains elusive. In this study, SIRT4 was found to inhibit PDAC by impacting mitochondrial homeostasis. SIRT4 deacetylated lysine 547 of SEL1L and increased the protein level
Dongnan Ping, Xiaofan Pu, Guoping Ding, Chaolei Zhang, Junbin Jin, Chengjie Xu, Jiazheng Liu, Shengnan Jia, Liping Cao   +8 more
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ALKB homolog 5 (ALKBH5)-induced circPUM1 upregulation facilitated the progression of neuroblastoma via miR-423–5p/PA2G4 axis

Pathology - Research and Practice, 2023
The oncogenic role of circPUM1 has been revealed in multiple cancers. Nevertheless, the specific role and molecular mechanism of circPUM1 in neuroblastoma (NB) have never been reported.The expression of genes was detected using RT-qPCR and Western Blot assay.
Lin Liu, He Zhao, Jing Li, Jie Huang, Yunyun Xu, Xiaolu Li, Yi Wu, Ping Li, Xinxian Guan, Ruze Tang   +9 more
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A positive feedback loop between AlkB homolog 5 and miR-193a-3p promotes growth and metastasis in esophageal squamous cell carcinoma

Human Cell, 2020
Esophageal squamous cell carcinoma (ESCC) is one of the most frequent malignancies worldwide. miR-193a-3p acts as an oncogene or tumor suppressor in different cancers. However, the functional role and regulatory mechanism of miR-193a-3p in ESCC remain to be elucidated.
Jinliang Xue, Peng Xiao, Xiangdong Yu, Xiao Zhang   +3 more
openalex   +4 more sources

Anti-Tumor Effect of AlkB Homolog 3 Knockdown in Hormone- Independent Prostate Cancer Cells

Current Cancer Drug Targets, 2012
Castrate resistant prostate cancer (CRPC) is a disease that is resistant to both hormone therapy and chemotherapy. At present, no curative therapy for CRPC has been established. Therefore, it is necessary to determine a novel molecular target for the development of therapeutic agents.
Kazuo Koike, Yuko Ueda, Hiroaki Hase, Kaori Kitae, Yasuyuki Fusamae, Seiko Masai, Takeshi Inagaki, Yasuka Saigo, Serabi Hirasawa, K Nakajima, Ikumi Ohshio, Y. Makino, Nakao Konishi, Hiroaki Yamamoto, Kazutake Tsujikawa   +14 more
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High expression of AlkB homolog 5 suppresses the progression of non‐small cell lung cancer by facilitating ferroptosis through m6A demethylation of SLC7A11

Environmental Toxicology
AbstractObjectiveNon‐small cell lung cancer (NSCLC) is a prevailing LC characterized by poor outcomes. AlkB homolog 5 (ALKBH5) functions as a tumor suppressor in several cancers. This study delved into the role of ALKBH5 in NSCLC development.MethodsTCGA database predicted ALKBH5 expression in NSCLC patients.
Zhangzhou Huang, Gen Lin, Yaping Hong, Lihong Weng, Kai Zhu, Wu Zhuang   +5 more
openalex   +3 more sources

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The AlkB Family of Fe (II)/Alpha-Ketoglutarate-Dependent Dioxygenases Modulates Embryogenesis through Epigenetic Regulation.

Current Stem Cell Research & Therapy, 2018
BACKGROUND The study of epigenetic regulation has made substantial progress in recent years. The AlkB family in E. coli was identified as a type of DNA repair enzyme that removes alkyl adducts from nucleobases. Recently, nine mammalian homologs, ALKBH1-9,
Yuting Liu, Q. Yuan, Liang Xie
semanticscholar   +1 more source

A new method for the detection of alkane-monooxygenase homologous genes (alkB) in soils based on PCR-hybridization

Journal of Microbiological Methods, 2006
An improved method was developed that allowed the specific detection of the gene alkB (coding for the rubredoxin dependent alkane monooxygenase) from bacteria without any obvious strain specific discrimination using a combination of PCR and hybridization.
Michael Schloter, Jean Charles Munch, Karin Kloos   +2 more
openaire   +3 more sources

Genome-wide characterization of the AlkB homolog (ALKBH) gene family in Litopenaeus vannamei identifies LvALKBH1 and LvALKBH8 as promising crustacean m6A demethylases involved in molting regulation and ammonia stress response

International Journal of Biological Macromolecules
Yiguo Lei, Boquan Wan, C. O. Ao, Miao Yang, Yue Jiang, Wei Wang   +5 more
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Abundance and Diversity of n-Alkane-Degrading Bacteria in a Forest Soil Co-Contaminated with Hydrocarbons and Metals: A Molecular Study on alkB Homologous Genes

Microbial Ecology, 2011
Unraveling functional genes related to biodegradation of organic compounds has profoundly improved our understanding of biological remediation processes, yet the ecology of such genes is only poorly understood. We used a culture-independent approach to assess the abundance and diversity of bacteria catalyzing the degradation of n-alkanes with a chain ...
Alfredo Pérez-de-Mora, Michael Schloter, Marion Engel   +2 more
openaire   +3 more sources

A comparative study of most probable number (MPN)-PCR vs. real-time-PCR for the measurement of abundance and assessment of diversity of alkB homologous genes in soil

Journal of Microbiological Methods, 2010
The utilization of quantitative PCR (qPCR) approaches such as MPN-qPCR and real-time-qPCR for in situ assessment of functional genes yields substantial quantitative and qualitative differences. We show this by targeting the alkB gene related to biodegradation of aliphatic alkanes in a set of environmental samples with differing hydrocarbon content.
Stephan Schulz, Michael Schloter, Alfredo Peréz-de-Mora, Marion Engel, Jean Charles Munch   +4 more
openaire   +2 more sources