The AlkB Homolog SlALKBH10B Negatively Affects Drought and Salt Tolerance in Solanum lycopersicum. [PDF]
Int J Mol Sci, 2023 ALKBH proteins, the homologs of Escherichia coli AlkB dioxygenase, constitute a single-protein repair system that safeguards cellular DNA and RNA against the harmful effects of alkylating agents. ALKBH10B, the first discovered N6-methyladenosine (m6A) demethylase in Arabidopsis (Arabidopsis thaliana), has been shown to regulate plant growth ...
Shen H +6 more
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AlkB homolog 3-mediated tRNA demethylation promotes protein synthesis in cancer cells [PDF]
Scientific Reports, 2017 AbstractThe mammalian AlkB homolog (ALKBH) family of proteins possess a 2-oxoglutarate- and Fe(II)-dependent oxygenase domain. A similar domain in the Escherichia coli AlkB protein catalyzes the oxidative demethylation of 1-methyladenine (1-meA) and 3-methylcytosine (3-meC) in both DNA and RNA.
Yasuyuki Fusamae +2 more
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Genome-Wide Identification and Expression Analysis of the ALKB Homolog Gene Family in Potato (Solanum tuberosum L.). [PDF]
Int J Mol SciN6-methyladenosine (m6A) is an abundant and pervasive post-transcriptional modification in eukaryotic mRNAs. AlkB homolog (ALKBH) proteins play crucial roles in RNA metabolism and translation, participating in m6A methylation modification to regulate plant development.
Li Y, Dong X, Ma J, Sui C, Jian H, Lv D.
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Role of the viral AlkB homologs in RNA repair [PDF]
, 2014 AlkB proteins that repair DNA via reversing methylation damage are conserved in a broad range of prokaryotes and eukaryotes including plants. Surprisingly, AlkB-domains were discovered in the genomes of numerous plant positive-strand RNA viruses, majority of which belong to the family Flexiviridae. The major goal of this research was to reveal the AlkB
Munir Mawassi, Valerian V. Dolja
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Non-homologous functions of the AlkB homologs [PDF]
Journal of Molecular Cell Biology, 2015 The DNA repair enzyme AlkB was identified in E. coli more than three decades ago. Since then, nine mammalian homologs, all members of the superfamily of alpha-ketoglutarate and Fe(II)-dependent dioxygenases, have been identified (designated ALKBH1-8 and FTO). While E.
Rune Ougland +3 more
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Alpha-Ketoglutarate-Dependent Dioxygenase AlkB Homolog 7 [PDF]
, 2020 National Cancer Institute
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Therapeutic potential of ALKB homologs for cardiovascular disease
Biomedicine & Pharmacotherapy, 2020 Cardiovascular diseases (CVDs) are the leading causes of human death. Recently, ALKB homologs, including ALKBH1-8 and FTO, have been found to have a variety of biological functions, such as histone demethylation, RNA demethylation, and DNA demethylation.
Mingzhu Xiao +5 more
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Tricarboxylic Acid Cycle Relationships with Non-Metabolic Processes: A Short Story with DNA Repair and Its Consequences on Cancer Therapy Resistance. [PDF]
Int J Mol SciMetabolic changes involving the tricarboxylic acid (TCA) cycle have been linked to different non-metabolic cell processes. Among them, apart from cancer and immunity, emerges the DNA dam- age response (DDR) and specifically DNA damage repair.
Álvarez-González E, Sierra LM.
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Homology modeling, molecular dynamics, and site-directed mutagenesis study of AlkB human homolog 1 (ALKBH1) [PDF]
Journal of Molecular Graphics and Modelling, 2014 The ability to repair DNA is important for the conservation of genetic information of living organisms. Cells have a number of ways to restore damaged DNA, such as direct DNA repair, base excision repair, and nucleotide excision repair. One of the proteins that can perform direct repair of DNA bases is Escherichia coli AlkB.
Pavel Silvestrov +4 more
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Role of the Demethylase AlkB Homolog H5 in the Promotion of Dentinogenesis
Frontiers in Physiology, 2022 Dentinogenesis is a key process in tooth formation and is regulated by a series of pre- and post-transcriptional regulations. N6-methyl-adenosine (m6A), which is the most prevalent internal chemical modification that can be removed by the RNA demethylase AlkB homolog H5 (ALKBH5), has recently been reported to be involved in several biological processes.
Cheng Tian +9 more
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