Results 11 to 20 of about 110,088 (171)
Genome-Wide Identification and Expression Analysis of the ALKB Homolog Gene Family in Potato (Solanum tuberosum L.). [PDF]
Int J Mol SciN6-methyladenosine (m6A) is an abundant and pervasive post-transcriptional modification in eukaryotic mRNAs. AlkB homolog (ALKBH) proteins play crucial roles in RNA metabolism and translation, participating in m6A methylation modification to regulate plant development.
Li Y, Dong X, Ma J, Sui C, Jian H, Lv D.
europepmc +5 more sources
Role of the viral AlkB homologs in RNA repair [PDF]
, 2014 AlkB proteins that repair DNA via reversing methylation damage are conserved in a broad range of prokaryotes and eukaryotes including plants. Surprisingly, AlkB-domains were discovered in the genomes of numerous plant positive-strand RNA viruses, majority of which belong to the family Flexiviridae. The major goal of this research was to reveal the AlkB
Munir Mawassi, Valerian V. Dolja
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Role of the Demethylase AlkB Homolog H5 in the Promotion of Dentinogenesis [PDF]
Frontiers in Physiology, 2022 Dentinogenesis is a key process in tooth formation and is regulated by a series of pre- and post-transcriptional regulations. N6-methyl-adenosine (m6A), which is the most prevalent internal chemical modification that can be removed by the RNA demethylase AlkB homolog H5 (ALKBH5), has recently been reported to be involved in several biological processes.
Cheng Tian +9 more
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AlkB homolog 3-mediated tRNA demethylation promotes protein synthesis in cancer cells [PDF]
Scientific Reports, 2017 AbstractThe mammalian AlkB homolog (ALKBH) family of proteins possess a 2-oxoglutarate- and Fe(II)-dependent oxygenase domain. A similar domain in the Escherichia coli AlkB protein catalyzes the oxidative demethylation of 1-methyladenine (1-meA) and 3-methylcytosine (3-meC) in both DNA and RNA.
Yuko Ueda +9 more
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An alkB gene homolog is differentially transcribed during the Caulobacter crescentus cell cycle [PDF]
Journal of Bacteriology, 1997 A Caulobacter crescentus alkB gene homolog was identified in a clone previously shown to contain the heat shock genes dnaK and dnaJ; the homolog is located upstream of dnaK and is transcribed in the opposite orientation. An analysis of the alkB gene has shown that the deduced amino acid sequence is that of a 21-kDa protein, which is 42% identical and ...
Débora Colombi, Suely Lopes Gomes
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Generalization of Classification of AlkB Family Alkane Monooxygenases from Rhodococcus (sensu lato) Group Based on Phylogenetic Analysis and Genomic Context Comparison. [PDF]
Int J Mol SciAlkane-oxidizing bacteria play a crucial role in the global carbon cycle. Rhodococcus species are well-known hydrocarbon degraders, distinguished by the harboring of multiple homologs of AlkB family alkane monooxygenases.
Petrikov KV +4 more
europepmc +2 more sources
Characterization of a Trypanosoma brucei Alkb homolog capable of repairing alkylated DNA [PDF]
Experimental Parasitology, 2012 Trypanosoma brucei encodes a protein (denoted TbABH) that is homologous to AlkB of Escherichia coli and AlkB homolog (ABH) proteins in other organisms, raising the possibility that trypanosomes catalyze oxidative repair of alkylation-damaged DNA. TbABH was cloned and expressed in E.
Jana M. Simmons +2 more
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Novel AlkB dioxygenases--alternative models for in silico and in vivo studies.
PLoS ONE, 2012 BackgroundALKBH proteins, the homologs of Escherichia coli AlkB dioxygenase, constitute a direct, single-protein repair system, protecting cellular DNA and RNA against the cytotoxic and mutagenic activity of alkylating agents, chemicals significantly ...
Damian Mielecki +8 more
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Frontiers in Cell and Developmental Biology, 2021 The AlkB family consists of Fe(II)- and α-ketoglutarate-dependent dioxygenases that can catalyze demethylation on a variety of substrates, such as RNA and DNA, subsequently affecting tumor progression and prognosis.
Geting Wu +8 more
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Human AlkB Homolog ABH8 Is a tRNA Methyltransferase Required for Wobble Uridine Modification and DNA Damage Survival [PDF]
Molecular and Cellular Biology, 2010 tRNA nucleosides are extensively modified to ensure their proper function in translation. However, many of the enzymes responsible for tRNA modifications in mammals await identification. Here, we show that human AlkB homolog 8 (ABH8) catalyzes tRNA methylation to generate 5-methylcarboxymethyl uridine (mcm(5)U) at the wobble position of certain tRNAs ...
Dragony Fu +8 more
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