Results 21 to 30 of about 1,546 (186)

Human AlkB Homolog 1 Is a Mitochondrial Protein That Demethylates 3-Methylcytosine in DNA and RNA [PDF]

Journal of Biological Chemistry, 2008
The Escherichia coli AlkB protein and human homologs hABH2 and hABH3 are 2-oxoglutarate (2OG)/Fe(II)-dependent DNA/RNA demethylases that repair 1-methyladenine and 3-methylcytosine residues. Surprisingly, hABH1, which displays the strongest homology to AlkB, failed to show repair activity in two independent studies.
Marianne P. Westbye, Emadoldin Feyzi, Per Arne, Cathrine Broberg Vågbø, Vivi Talstad, Bodil Kavli, Lars Hagen, Ottar Sundheim, Mansour Akbari, Nina‐Beate Liabakk, Geir Slupphaug, Marit Otterlei, Hans E. Krokan   +12 more
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An alkB gene homolog is differentially transcribed during the Caulobacter crescentus cell cycle [PDF]

Journal of Bacteriology, 1997
A Caulobacter crescentus alkB gene homolog was identified in a clone previously shown to contain the heat shock genes dnaK and dnaJ; the homolog is located upstream of dnaK and is transcribed in the opposite orientation. An analysis of the alkB gene has shown that the deduced amino acid sequence is that of a 21-kDa protein, which is 42% identical and ...
Débora Colombi, Suely Lopes Gomes
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Case Report: Biallelic Variant in the tRNA Methyltransferase Domain of the AlkB Homolog 8 Causes Syndromic Intellectual Disability

Frontiers in Genetics, 2022
Intellectual disability (ID) has become very common and is an extremely heterogeneous disorder, where the patients face many challenges with deficits in intellectual functioning and adaptive behaviors. A single affected family revealed severe disease phenotypes such as ID, developmental delay, dysmorphic facial features, postaxial polydactyly type B ...
Ahmed Waqas, Anam Nayab, Shabnam Shaheen, Safdar Abbas, Muhammad Latif, Misbahuddin M. Rafeeq, Ibtesam S. Al-Dhuayan, Amany I. Alqosaibi, Mashael M. Alnamshan, Ziaullah M. Sain, Alaa Hamed Habib, Qamre Alam, Muhammad Umair, Muhammad Arif Nadeem Saqib   +13 more
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Characterization of a Trypanosoma brucei Alkb homolog capable of repairing alkylated DNA [PDF]

Experimental Parasitology, 2012
Trypanosoma brucei encodes a protein (denoted TbABH) that is homologous to AlkB of Escherichia coli and AlkB homolog (ABH) proteins in other organisms, raising the possibility that trypanosomes catalyze oxidative repair of alkylation-damaged DNA. TbABH was cloned and expressed in E.
Jana M. Simmons, Donna J. Koslowsky, Robert P. Hausinger   +2 more
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The Schizosaccharomyces pombe AlkB homolog Abh1 exhibits AP lyase activity but no demethylase activity

DNA Repair, 2012
2-Oxoglutarate (2OG) and iron (Fe(II)) dependent dioxygenases catalyze a wide range of biological oxidations, including hydroxylation and demethylation of proteins and nucleic acids. AlkB from Escherichia coli directly reverses certain methyl lesions in DNA, and defines a subfamily of 2OG/Fe(II) dioxygenases that has so far been shown to be involved in
Hanne Korvald, Pål Ø. Falnes, Jon K. Laerdahl, Magnar Bjørås, Ingrun Alseth   +4 more
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The Atomic Resolution Structure of Human AlkB Homolog 7 (ALKBH7), a Key Protein for Programmed Necrosis and Fat Metabolism [PDF]

Journal of Biological Chemistry, 2014
ALKBH7 is the mitochondrial AlkB family member that is required for alkylation- and oxidation-induced programmed necrosis. In contrast to the protective role of other AlkB family members after suffering alkylation-induced DNA damage, ALKBH7 triggers the collapse of mitochondrial membrane potential and promotes cell death.
Guoqiang Wang, Qingzhong He, Chong Feng, Yang Liu, Zengqin Deng, Xiaoxuan Qi, Wei Wu, Pinchao Mei, Zhongzhou Chen   +8 more
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Oxidative demethylation of DNA damage by Escherichia coli AlkB and its human homologs ABH2 and ABH3 [PDF]

, 2003
The E. coli AlkB protein was implicated in the repair or tolerance of DNA methylation damage. However, despite the early isolation of an E. coli alkB mutant, the function of the AlkB protein had not been resolved (Kataoka et al., 1983). The E.
Trewick, Sarah Catherine
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Crystal Structure and RNA Binding Properties of the RNA Recognition Motif (RRM) and AlkB Domains in Human AlkB Homolog 8 (ABH8), an Enzyme Catalyzing tRNA Hypermodification [PDF]

Journal of Biological Chemistry, 2011
Humans express nine paralogs of the bacterial DNA repair enzyme AlkB, an iron/2-oxoglutarate-dependent dioxygenase that reverses alkylation damage to nucleobases. The biochemical and physiological roles of these paralogs remain largely uncharacterized, hampering insight into the evolutionary expansion of the AlkB family. However, AlkB homolog 8 (ABH8),
Chiara Pastore, Irini Topalidou, F. Forouhar, Amy Yan, Matthew Levy, J.F. Hunt   +5 more
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MiR-141-3p Promotes Malignant Progression in Prostate Cancer through AlkB Homolog 5-Mediated m6A Modification of Protein Arginine Methyltransferase 6

Chinese Journal of Physiology, 2023
Prostate cancer (PCa) is one of the leading causes of cancer-related death in males worldwide and exploring more reliable biomarkers for PCa is essential for the diagnosis and therapeutics for the disease. Although the functions of miR-141-3p and AlkB homolog 5 (ALKBH5) were identified in some cancers, whether they were ...
Xun Li, Bide Liu, Shuheng Wang, Jiuzhi Li, Xiaohu Ge   +4 more
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Genome-Wide Identification and Expression Analysis of the AlkB Homolog Gene Family in Tamarix chinensis [PDF]

Forests
Tamarix chinensis (T. chinensis), an esteemed salt-tolerant plant, holds significant importance in elucidating mechanisms of plant stress adaptation. The ALKBH genes family, which is involved in RNA N6-methyladenosine (m6A) demethylation, plays a crucial role in plant growth, development, and stress responses.
Jingjing Zhang, Wenhui Guo, Huijuan Yin, Kongshu Ji, Qiong Yu   +4 more
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