Results 21 to 30 of about 110,088 (171)

Case Report: Biallelic Variant in the tRNA Methyltransferase Domain of the AlkB Homolog 8 Causes Syndromic Intellectual Disability [PDF]

Frontiers in Genetics, 2022
Intellectual disability (ID) has become very common and is an extremely heterogeneous disorder, where the patients face many challenges with deficits in intellectual functioning and adaptive behaviors. A single affected family revealed severe disease phenotypes such as ID, developmental delay, dysmorphic facial features, postaxial polydactyly type B ...
Ahmed Waqas, Anam Nayab, Shabnam Shaheen, Safdar Abbas, Muhammad Latif, Misbahuddin M. Rafeeq, Ibtesam S. Al-Dhuayan, Amany I. Alqosaibi, Mashael M. Alnamshan, Ziaullah M. Sain, Alaa Hamed Habib, Qamre Alam, Muhammad Umair, Muhammad Arif Nadeem Saqib   +13 more
openalex   +3 more sources

Homology modeling, molecular dynamics, and site-directed mutagenesis study of AlkB human homolog 1 (ALKBH1) [PDF]

Journal of Molecular Graphics and Modelling, 2014
The ability to repair DNA is important for the conservation of genetic information of living organisms. Cells have a number of ways to restore damaged DNA, such as direct DNA repair, base excision repair, and nucleotide excision repair. One of the proteins that can perform direct repair of DNA bases is Escherichia coli AlkB.
Pavel Silvestrov, Tina Müller, Kristen N. Clark, Robert P. Hausinger, G. Andrés Cisneros   +4 more
openalex   +4 more sources

The Schizosaccharomyces pombe AlkB homolog Abh1 exhibits AP lyase activity but no demethylase activity

DNA Repair, 2012
2-Oxoglutarate (2OG) and iron (Fe(II)) dependent dioxygenases catalyze a wide range of biological oxidations, including hydroxylation and demethylation of proteins and nucleic acids. AlkB from Escherichia coli directly reverses certain methyl lesions in DNA, and defines a subfamily of 2OG/Fe(II) dioxygenases that has so far been shown to be involved in
Hanne Korvald, Pål Ø. Falnes, Jon K. Laerdahl, Magnar Bjørås, Ingrun Alseth   +4 more
openalex   +4 more sources

RNA or DNA? Revisiting the Chemical Nature of the Cenancestral Genome. [PDF]

J Mol Evol
One of the central issues in the understanding of early cellular evolution is the characterisation of the cenancestor. This includes the description of the chemical nature of its genome.
Cottom-Salas W, Becerra A, Lazcano A.
europepmc   +2 more sources

Crystal Structure and RNA Binding Properties of the RNA Recognition Motif (RRM) and AlkB Domains in Human AlkB Homolog 8 (ABH8), an Enzyme Catalyzing tRNA Hypermodification [PDF]

Journal of Biological Chemistry, 2011
Humans express nine paralogs of the bacterial DNA repair enzyme AlkB, an iron/2-oxoglutarate-dependent dioxygenase that reverses alkylation damage to nucleobases. The biochemical and physiological roles of these paralogs remain largely uncharacterized, hampering insight into the evolutionary expansion of the AlkB family. However, AlkB homolog 8 (ABH8),
Chiara Pastore, Irini Topalidou, F. Forouhar, Amy Yan, Matthew Levy, J.F. Hunt   +5 more
openalex   +3 more sources

3,N4-Etheno-5-methylcytosine blocks TET1-3 oxidation but is repaired by ALKBH2, 3 and FTO. [PDF]

Nucleic Acids Res
5-Methyldeoxycytidine (5mC) is a major epigenetic marker that regulates cellular functions in mammals. Endogenous lipid peroxidation can convert 5mC into 3,N4-etheno-5-methylcytosine (ϵ5mC).
Ma J, Qi R, Harcourt EM, Chen YT, Barbosa GM, Peng Z, Howarth S, Delaney S, Li D.   +8 more
europepmc   +2 more sources

Characterization of human AlkB homolog 1 produced in mammalian cells and demonstration of mitochondrial dysfunction in ALKBH1-deficient cells

Biochemical and Biophysical Research Communications, 2017
Alkbh1 is a mammalian homolog of the Escherichia coli DNA repair enzyme AlkB, an Fe(II) and 2-oxoglutarate dependent dioxygenase that removes alkyl lesions from DNA bases. The human homolog ALKBH1 has been associated with six different enzymatic activities including DNA, mRNA, or tRNA hydroxylation, cleavage at abasic (AP) sites in DNA, as well as ...
Tina Müller, Sarah Struble, Katheryn Meek, Robert P. Hausinger   +3 more
openalex   +5 more sources

MiR-141-3p Promotes Malignant Progression in Prostate Cancer through AlkB Homolog 5-Mediated m6A Modification of Protein Arginine Methyltransferase 6

Chinese Journal of Physiology, 2023
Prostate cancer (PCa) is one of the leading causes of cancer-related death in males worldwide and exploring more reliable biomarkers for PCa is essential for the diagnosis and therapeutics for the disease. Although the functions of miR-141-3p and AlkB homolog 5 (ALKBH5) were identified in some cancers, whether they were ...
Xun Li, Bide Liu, Shuheng Wang, Jiuzhi Li, Xiaohu Ge   +4 more
openalex   +4 more sources

Engineering of Transmembrane Alkane Monooxygenases to Improve a Key Reaction Step in the Synthesis of Polymer Precursor Tulipalin A

Angewandte Chemie International Edition, Accepted Article.
The α‐methylene‐γ‐butyrolactone tulipalin A, a defense compound found in tulips, can polymerize via addition at the vinyl group or via ring‐opening polymerization, making it a highly promising monomer for bio‐based polymers. Since the biosynthesis of tulipalin A in plants remains elusive, we propose an alternative pathway for its synthesis starting ...
Nigl A, Delsoglio V, Grgić M, Malihan-Yap L, Myrtollari K, Spasic J, Winkler M, Oberdorfer G, Taden A, Anić I, Kourist R.   +10 more
europepmc   +2 more sources

Proteome expansion in the Potyviridae evolutionary radiation. [PDF]

FEMS Microbiol Rev, 2022
Potyviridae, the largest family of known RNA viruses (realm Riboviria), belongs to the picorna-like supergroup and has important agricultural and ecological impacts.
Pasin F, Daròs JA, Tzanetakis IE.
europepmc   +2 more sources