The Atomic Resolution Structure of Human AlkB Homolog 7 (ALKBH7), a Key Protein for Programmed Necrosis and Fat Metabolism [PDF]
Journal of Biological Chemistry, 2014 ALKBH7 is the mitochondrial AlkB family member that is required for alkylation- and oxidation-induced programmed necrosis. In contrast to the protective role of other AlkB family members after suffering alkylation-induced DNA damage, ALKBH7 triggers the collapse of mitochondrial membrane potential and promotes cell death.
Guoqiang Wang +8 more
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Molecular Cloning and Functional Analysis of a Human cDNA Encoding an Escherichia Coli AlkB Homolog, a Protein Involved in DNA Alkylation Damage Repair [PDF]
Nucleic Acids Research, 1996 The Escherichia coli AlkB protein is involved in protecting cells against mutation and cell death induced specifically by SN2-type alkylating agents such as methyl methanesulfonate (MMS). A human cDNA encoding a polypeptide homologous to E.coli AlkB was discovered by searching a database of expressed sequence tags (ESTs) derived from high throughput ...
Y.-F. Wei +3 more
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Genome Sequencing Reveals the Potential of Achromobacter sp. HZ01 for Bioremediation
Frontiers in Microbiology, 2017 Petroleum pollution is a severe environmental issue. Comprehensively revealing the genetic backgrounds of hydrocarbon-degrading microorganisms contributes to developing effective methods for bioremediation of crude oil-polluted environments.
Yue-Hui Hong +7 more
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CpG promoter methylation of the ALKBH3 alkylation repair gene in breast cancer
BMC Cancer, 2017 Background DNA repair of alkylation damage is defective in various cancers. This occurs through somatically acquired inactivation of the MGMT gene in various cancer types, including breast cancers. In addition to MGMT, the two E.
Olafur Andri Stefansson +8 more
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Formation and Repair of Tobacco Carcinogen-Derived Bulky DNA Adducts
Journal of Nucleic Acids, 2010 DNA adducts play a central role in chemical carcinogenesis. The analysis of formation and repair of smoking-related DNA adducts remains particularly challenging as both smokers and nonsmokers exposed to smoke are repetitively under attack from complex ...
Bo Hang
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Extracellular Vesicles Derived From Regenerating Tissue Promote Stem Cell Proliferation in the Planarian <i>Schmidtea mediterranea</i>. [PDF]
J Extracell BiolWe enriched EVs from the tissue of the planarian flatworm Schmidtea mediterranea, which is capable of whole‐body regeneration. We characterized these EVs using NTA, TEM and Capillary Western Blot, and demonstrated that planarian cells take up EVs.
Avalos Najera PN +2 more
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AlkB Homolog H5 Attenuates TGF-β1-Induced Epithelial-Mesenchymal Transition of Retinal Pigment Epithelial Cells via Regulating Zinc Finger E-box Binding Homeobox 1 [PDF]
Pakistan Journal of ZoologyYunzhi Lin
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Human ALKBH4 interacts with proteins associated with transcription. [PDF]
PLoS ONE, 2012 The Fe(II)- and 2-oxoglutarate (2OG)-dependent dioxygenase AlkB from E. coli is a demethylase which repairs alkyl lesions in DNA, as well as RNA, through a direct reversal mechanism. Humans possess nine AlkB homologs (ALKBH1-8 and FTO). ALKBH2 and ALKBH3
Linn G Bjørnstad +5 more
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Bioinformatic mapping of AlkB homology domains in viruses [PDF]
BMC Genomics, 2005 Abstract Background AlkB-like proteins are members of the 2-oxoglutarate- and Fe(II)-dependent oxygenase superfamily. In Escherichia coli the protein protects RNA and DNA against damage from methylating agents.
Marit S Bratlie, Finn Drabløs
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