Results 41 to 50 of about 1,546 (186)

Alkbh8 Regulates Selenocysteine-Protein Expression to Protect against Reactive Oxygen Species Damage [PDF]

, 2015
Environmental and metabolic sources of reactive oxygen species (ROS) can damage DNA, proteins and lipids to promote disease. Regulation of gene expression can prevent this damage and can include increased transcription, translation and post translational
Begley, Thomas J., Begley, Ulrike, Clark, Ryan, Dedon, Peter C., Dziergowska, Agnieszka, Endres, Lauren, Gu, Chen, Małkiewicz, Andrzej, Melendez, J. Andres   +8 more
core   +6 more sources

Role of ALKBH1 in the Core Transcriptional Network of Embryonic Stem Cells

Cellular Physiology and Biochemistry, 2016
Background/Aims: ALKBH1, an AlkB homologue in the 2-oxoglutarate and Fe2+ dependent hydroxylase family, is a histone dioxygenase that removes methyl groups from histone H2A. Studies of transgenic mice lacking Alkbh1 reveal that most Alkbh1-/- embryos die
Rune Ougland, Ida Jonson, Marivi Nabong Moen, Gaute Nesse, Gry Asker, Arne Klungland, Elisabeth Larsen   +6 more
doaj   +1 more source

The interaction between ALKBH2 DNA repair enzyme and PCNA is direct, mediated by the hydrophobic pocket of PCNA and perturbed in naturally-occurring ALKBH2 variants [PDF]

, 2015
Human AlkB homolog 2 (ALKBH2) is a DNA repair enzyme that catalyzes the direct reversal of DNA methylation damage through oxidative demethylation. While ALKBH2 colocalizes with proliferating cell nuclear antigen (PCNA) in DNA replication foci, it remains
Fu, Dragony, Hübscher, Ullrich, Samson, Leona D, Van Loon, Barbara   +3 more
core   +1 more source

Chemical biology of mutagenesis and DNA repair: cellular responses to DNA alkylation [PDF]

, 2009
The reaction of DNA-damaging agents with the genome results in a plethora of lesions, commonly referred to as adducts. Adducts may cause DNA to mutate, they may represent the chemical precursors of lethal events and they can disrupt expression of genes ...
Essigmann, John M., Li, Deyu, Shrivastav, Nidhi   +2 more
core   +3 more sources

Genome Sequencing Reveals the Potential of Achromobacter sp. HZ01 for Bioremediation

Frontiers in Microbiology, 2017
Petroleum pollution is a severe environmental issue. Comprehensively revealing the genetic backgrounds of hydrocarbon-degrading microorganisms contributes to developing effective methods for bioremediation of crude oil-polluted environments.
Yue-Hui Hong, Cong-Cong Ye, Qian-Zhi Zhou, Xiao-Ying Wu, Jian-Ping Yuan, Juan Peng, Hailin Deng, Jiang-Hai Wang   +7 more
doaj   +1 more source

Recognition and processing of a new repertoire of DNA substrates by human 3-methyladenine DNA glycosylase (AAG) [PDF]

, 2009
The human 3-methyladenine DNA glycosylase (AAG) recognizes and excises a broad range of purines damaged by alkylation and oxidative damage, including 3-methyladenine, 7-methylguanine, hypoxanthine (Hx), and 1,N[superscript 6]-ethenoadenine (εA).
Aas P. A., Abner C. W., Adhikari S., Berti P. J., Bjelland S., Chakravarti D., Delaney J. C., Delaney J. C., Dianov G., Dosanjh M. K., Eftedal I., el Ghissassi F., Elder R. H., Engelward B. P., Falnes P. O., Falnes P. O., Falnes P. O., Frick L. E., Friedberg E. C., Gallagher P. E., Goodenough A. K., Guengerich F. P., Guengerich F. P., Guengerich F. P., Guliaev A. B., Hang B., Haushalter K. A., Hitchcock T. M., Koivisto P., Kusmierek J. T., Kusmierek J. T., Lau A. Y., Lau A. Y., Leonard N. J., Ludlum D. B., Miao F., Mishina Y., Nilsen H., Ougland R., O’Brien P. J., O’Brien P. J., O’Connor T. R., O’Connor T. R., O’Neill R. J., Pearl L. H., Pendlebury A., Ringvoll J., Roy R., Samson L., Saparbaev M., Saparbaev M., Saparbaev M., Singer B., Trewick S. C., Wang H., Westbye M. P., Wuenschell G. E., Wyatt M. D.   +57 more
core   +1 more source

CpG promoter methylation of the ALKBH3 alkylation repair gene in breast cancer

BMC Cancer, 2017
Background DNA repair of alkylation damage is defective in various cancers. This occurs through somatically acquired inactivation of the MGMT gene in various cancer types, including breast cancers. In addition to MGMT, the two E.
Olafur Andri Stefansson, Stefan Hermanowicz, Jasper van der Horst, Holmfridur Hilmarsdottir, Zuzanna Staszczak, Jon Gunnlaugur Jonasson, Laufey Tryggvadottir, Thorkell Gudjonsson, Stefan Sigurdsson   +8 more
doaj   +1 more source

Functional diversity of 2-oxoglutarate/Fe(II)-dependent dioxygenases in plant metabolism [PDF]

, 2014
Oxidative enzymes catalyze many different reactions in plant metabolism. Among this suite of enzymes are the 2-oxoglutarate/Fe(II)-dependent dioxygenases (2-ODDs). Cytochromes P450 (CYPs) as often considered the most versatile oxidative enzymes in nature,
Peter J. Facchini, Scott C. Farrow
core   +2 more sources

Oil degradation and biosurfactant production by the deep sea bacterium Dietzia maris As-13-3 [PDF]

, 2014
: Recent investigations of extreme environments have revealed numerous bioactive natural products. However, biosurfactant-producing strains from deep sea extreme environment are largely unknown. Here, we show that Dietzia maris As-13-3 isolated from deep
Bobo Cai, Wanpeng Wang, Zongze Shao
core   +3 more sources

Electrochemical Characterization of Escherichia coli Adaptive Response Protein AidB [PDF]

, 2012
When exposed to known DNA-damaging alkylating agents, Escherichia coli cells increase production of four DNA repair enzymes: Ada, AlkA, AlkB, and AidB. The role of three enzymes (Ada, AlkA, and AlkB) in repairing DNA lesions has been well characterized ...
Becker, Bowles, Byron, Catherine Drennan, Chohan, Cintyu Wong, Clark, Delaney, Demple, Evensen, Falnes, Falnes, Fink, Frerman, Frick, Ghisla, Hamill, He, Husain, Johnson, Karran, Kim, Landini, Landini, Lenn, Leys, Maier, Marco Jost, Massey, Massey, Massey, Michael Hamill, Mulrooney, Nicholas Bene, Pace, Rippa, Roberts, Roberts, Rohankhedkar, Saenger, Samson, Sean Elliott, Sedgwick, Sedgwick, Sedgwick, Stankovich, Stiehler, Swanson, Toogood, Toogood, Trewick, Vetter, Volkert, Volkert   +53 more
core   +2 more sources