Results 41 to 50 of about 110,088 (171)
Schizosaccharomyces pombe Ofd2 is a nuclear 2-oxoglutarate and iron dependent dioxygenase interacting with histones. [PDF]
PLoS ONE, 2011 2-Oxoglutarate (2OG) dependent dioxygenases are ubiquitous iron containing enzymes that couple substrate oxidation to the conversion of 2OG to succinate and carbon dioxide.
Hanne Korvald +6 more
doaj +1 more source
Role of RNA modifications in carcinogenesis and carcinogen damage response
Molecular Carcinogenesis, Volume 62, Issue 1, Page 24-37, January 2023., 2023 Abstract The field of epitranscriptomics encompasses the study of post‐transcriptional RNA modifications and their regulatory enzymes. Among the numerous RNA modifications, N6‐methyladenosine (m6A) has been identified as the most common internal modification of messenger RNA (mRNA).
Michelle Verghese +2 more
wiley +1 more source
AlkB homologs in metazoans – an applied bioinformatics and experimental DNA/RNA repair study
, 2015 Abstract E. coli AlkB protein was discovered three decades ago and is known to be involved in direct damage reversal of methylation lesions in DNA and RNA through oxidative demethylation. The protein belongs to the superfamily of 2-oxoglutarate and Fe(II)-dependent dioxygenases. Nine mammalian homologs of AlkB, ALKBH1-8 and FTO have been identified. In
Roza Berhanu Lemma
openalex +2 more sources
Computational Investigations of Selected Enzymes From Two Iron and α-ketoglutarate-Dependent Families [PDF]
, 2021 DNA alkylation is used as the key epigenetic mark in eukaryotes, however, most alkylation in DNA can result in deleterious effects. Therefore, this process needs to be tightly regulated. AlkB and TET are families within the Fe and $\alpha$-kg-dependent superfamily of enzymes that are tasked with dealkylating DNA and RNA in cells.
arxiv +1 more source
Transient kinetic analysis of oxidative dealkylation by the direct reversal DNA repair enzyme AlkB
Journal of Biological Chemistry, 2020 AlkB is a bacterial Fe(II)– and 2-oxoglutarate–dependent dioxygenase that repairs a wide range of alkylated nucleobases in DNA and RNA as part of the adaptive response to exogenous nucleic acid–alkylating agents.
M. R. Baldwin +2 more
semanticscholar +1 more source
Role of ALKBH1 in the Core Transcriptional Network of Embryonic Stem Cells
Cellular Physiology and Biochemistry, 2016 Background/Aims: ALKBH1, an AlkB homologue in the 2-oxoglutarate and Fe2+ dependent hydroxylase family, is a histone dioxygenase that removes methyl groups from histone H2A. Studies of transgenic mice lacking Alkbh1 reveal that most Alkbh1-/- embryos die
Rune Ougland +6 more
doaj +1 more source
Twisted Hochschild homology and MacLane homology [PDF]
Algebr. Geom. Topol. 7 (2007) 1071-1079, 2007 We prove vanishing results for Hochschild and MacLane homologies.
arxiv +1 more source
Journal of Biological Chemistry, 2015 The AlkB family of Fe(II)- and α-ketoglutarate-dependent dioxygenases is a class of ubiquitous direct reversal DNA repair enzymes that remove alkyl adducts from nucleobases by oxidative dealkylation.
B. Fedeles +4 more
semanticscholar +1 more source
Brown's criterion in Bredon homology [PDF]
Homology Homotopy Appl. 15 (2013), 153-162, 2012 We translate Brown's criterion for homological finiteness properties to the setting of Bredon homology.
arxiv +1 more source
Knot Floer homology, link Floer homology and link detection [PDF]
Algebr. Geom. Topol. 24 (2024) 159-181, 2020 We give new link detection results for knot and link Floer homology inspired by recent work on Khovanov homology. We show that knot Floer homology detects $T(2,4)$, $T(2,6)$, $T(3,3)$, $L7n1$, and the link $T(2,2n)$ with the orientation of one component reversed. We show link Floer homology detects $T(2,2n)$ and $T(n,n)$, for all $n$.
arxiv +1 more source