Results 71 to 80 of about 96,389 (286)

Recent developments in copper-catalyzed radical alkylations of electron-rich π-systems

Beilstein Journal of Organic Chemistry, 2015
Recently, a number of papers have emerged demonstrating copper-catalyzed alkylation reactions of electron-rich small molecules. The processes are generally thought to be related to long established atom-transfer radical reactions.
Kirk W. Shimkin, Donald A. Watson
doaj   +1 more source

Natural Products Inspired Scaffold Diversification Leads to Unnatural Molecular Warhead and Covalent Strategy to Modulating Protein Function through Electrophilic Bromine Transfer

Advanced Science, EarlyView.
We report a new thiolate‐reactive α,α‐gem‐dibromo lactam warhead that activates transcription factor Nrf2 and demonstrates anti‐inflammatory activities, which have implications in cancer, neurodegeneration, and cardiovascular diseases. RNA‐seq illuminated detailed transcriptional profiles, and chemical reactions with cysteine‐containing compounds ...
Beau R. Brummel, Sofia Kokkaliari, Qiwen Gao, Jinjing Chen, Larissa Costa de Almeida, Srinivasarao Tenneti, Derek A. Leas, Eli Levit, Lewis S. Alexander, Khalil A. Abboud, Pingrong Wei, Michael D. Cameron, James R. Rocca, Ranjala Ratnayake, Donna D. Zhang, Hendrik Luesch, Robert W. Huigens III   +16 more
wiley   +1 more source

Immobilization of MoO2(acac)2 on Multiwall Carbon Nano Tube and Epoxidation of Alkenes [PDF]

Iranian Journal of Chemistry & Chemical Engineering, 2019
The acidic group (-CO2H) of MultiWall Carbon Nanotube (MWCNT) converted to acyl chloride group (-COCl) producing of MVCNT@COCl. Then the reaction of MVCNT@COCl and MoO2(acac)2 resulted in direct immobilization of the MoO2(acac)2 and the formation of ...
Mahdieh Nafar, Gholamhossein Grivani
doaj  

Cold Orthogonal Translation: A Psychrophilic Pyrrolysyl‐tRNA Synthetase Boosts Genetic Code Expansion in E. coli

Advanced Science, EarlyView.
ABSTRACT Orthogonal translation systems (OTSs) enable site‐specific incorporation of non‐canonical amino acids (ncAAs) and are central to genetic code expansion. Current engineering strategies typically rely on hyperstable aminoacyl tRNA synthetase (aaRS) scaffolds to tolerate destabilizing mutations required for substrate diversification.
Nikolaj G. Koch, Peter Goettig, Michael A. Nash, Juri Rappsilber, Nediljko Budisa   +4 more
wiley   +1 more source

KleTy: integrated typing scheme for core genome and plasmids reveals repeated emergence of multi-drug resistant epidemic lineages in Klebsiella worldwide

Genome Medicine
Background Clinically important lineages in Klebsiella, especially those expressing multi-drug resistance (MDR), pose severe threats to public health worldwide.
Heng Li, Xiao Liu, Shengkai Li, Jie Rong, Shichang Xie, Yuan Gao, Ling Zhong, Quangui Jiang, Guilai Jiang, Yi Ren, Wanping Sun, Yuzhi Hong, Zhemin Zhou   +12 more
doaj   +1 more source

Spontaneous Non‐Catalyzed Molecular Reactions and Interactions in the Human Body: Biomedical Implications

Advanced Science, EarlyView.
ABSTRACT The human body functions as a natural reactor for a vast network of chemical and biological reactions and physical interactions among small molecules, proteins, cells, and numerous other components. These reactions/interactions are essential for maintaining normal physiological functions.
Yuhao Cai, Chao Zhao
wiley   +1 more source

New developments in gold-catalyzed manipulation of inactivated alkenes

Beilstein Journal of Organic Chemistry, 2013
Over the recent years, the nucleophilic manipulation of inactivated carbon–carbon double bonds has gained remarkable credit in the chemical community.
Michel Chiarucci, Marco Bandini
doaj   +1 more source

A Green Approach: Vicinal Oxidative Electrochemical Alkene Difunctionalization

ChemElectroChem, 2018
The use of electrochemistry is now regarded as one of the most efficient methodologies in which to synthesize highly functionalized moieties, such as those of the difunctionalized vicinal alkene family, from more simplistic and commercially available ...
Guilherme M. Martins, Bahareh Shirinfar, Tomas Hardwick, Nisar Ahmed   +3 more
semanticscholar   +1 more source

Integrating Machine Learning With Constant‐Potential Simulation to Unravel Charge‐Transfer Mechanisms in Electrochemical Nitrogen Fixation

Advanced Science, EarlyView.
Integrating interpretable machine learning with the fixed‐potential method reveals a novel mechanism: the catalytic activity of the electrochemical nitrogen reduction reaction is governed by partial charge transfer, induced by variations in the intermediate potential of zero charge under constant potential.
Yufei Xue, Dushuo Feng, Yuefei Zhang, Yang Zhang, Yalong Jiao, Aijun Du, Guoping Gao   +6 more
wiley   +1 more source

HAT-Initiated Fragmentation of 4-(Dimethylamino)-1-((3-methylbut-2-en-1-yl)oxy)-3-phenylbut-3-en-2-one

Molbank
An alkene-tethered enaminone 7 was synthesized in four steps from bromoacetic acid and 3,3-dimethylallyl alcohol. The enaminone was fully characterized, including UV-Vis spectra.
Andrej Bogataj, Luka Ciber, Nejc Petek, Franc Požgan, Jurij Svete, Bogdan Štefane, Uroš Grošelj   +6 more
doaj   +1 more source