Results 121 to 130 of about 127,440 (199)

GPX4 Inhibitor Resistance and Metastatic Features in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
This study establishes breast cancer cell lines that are resistant to glutathione peroxidase 4 inhibitors (GPX4i) in vitro and investigates the metastatic capacity of the GPX4i‐resistant versus parental lines in vivo. GPX4i‐resistant cells survive upon intravenous injection, but lose capacity to spontaneously metastasize.
Marie Sabatier, Mayher Kaur, Milena Chaufan, Felix‐Levin Hormann, Luiza Martins Nascentes Melo, Mario Palma, Jordan Torpey, Yanshan Liang, Alanis Carmona, Cameron Fraser, Midori Flores, Krystina J. Szylo, Mahsa Yavari, Sheng Hui, Alpaslan Tasdogan, Sven Heiles, Jessalyn M. Ubellacker   +16 more
wiley   +1 more source

<i>De Novo</i> Drug Design, Synthesis, Biological Evaluation, and Structural Examination of Novel Coumarin-Based Pyrimidine Co-Drugs Accompanied by Molecular Docking and DFT Studies. [PDF]

ACS Omega
Naz N, Nazli ZI, Parveen S, Shafiq N.
europepmc   +1 more source

Illuminating Mitochondrial RNA G‐Quadruplexes as Structural Brakes on RNA Granule Assembly and OXPHOS

Advanced Science, EarlyView.
A new fluorescent probe, MitoQUMA, brings mitochondrial RNA G‐quadruplexes (mtRNA G4s) into view in live cells. This tool reveals that excessive mtRNA G4 formation halts mitochondrial RNA granule (MRG) assembly, opposite to the phase‐separation role of cytoplasmic RNA G4s. A chemical genetic screen further identifies a Wnt/β‐catenin–GRSF1–mtRNA G4 axis
Gui‐Xue Tang, Jia‐Tong Yan, Mao‐Lin Li, Cui Zhou, Jian Wang, Shuo‐Bin Chen, Zhi‐Shu Huang, Jia‐Heng Tan   +7 more
wiley   +1 more source

Photoenzymatic Csp³-Csp³ bond formation via enzyme-templated radical-radical coupling. [PDF]

Proc Natl Acad Sci U S A
Liu Y, Oblinsky DG, Dell'Orletta G, Di Fonte N, Sorigue D, Page CG, Daidone I, Scholes GD, Hyster TK.   +8 more
europepmc   +1 more source

In‐Operando FTIR Study to Investigate the Effect of Varying Lithium Salts on Solid Electrolyte Interface (SEI) Evolution in Lithium Metal Batteries

Advanced Science, EarlyView.
A clear correlation between electrolyte salt chemistry and Solid Electrolyte Interface (SEI) performance in lithium metal batteries is established using in operando FTIR spectroscopy. This study shows that LiTFSI instantaneously forms a robust, inorganic organic hybrid SEI (LiF, Li3N, Li2O, ROCO2Li, ROLi) that minimizes overpotential, while less ...
Samia Rahman, Rhyz Pereira, Jantakan Nedsaengtip, Vibha Kalra   +3 more
wiley   +1 more source

Shining light on the mechanism of photochemical alkene formation in vitamin B₁₂. [PDF]

Chem Sci
Mukherjee A, Wu SY, Cooper DJ, Hendrickson R, Sension RJ, Lehnert N, Penner-Hahn JE.   +6 more
europepmc   +1 more source

Self‐Healing Starch‐Based Ionogels with Hydroneutral Dipole–Dipole Interactions

Advanced Science, EarlyView.
This work introduces starch‐based, conductive, underwater‐healable, and transparent ionogels for soft electronics (SCUTEs). Starch macromolecules are partially substituted with cyanoethyl groups and incorporated with hydrophobic ionic liquid. The polar yet hydroneutral cyanoethyl groups facilitate strong dynamic dipole–dipole interactions that remain ...
J. Justin Koh, Jiayi Liu, Xue Qi Koh, Binting Huang, Szu Cheng Lai, Jayce Jian Wei Cheng, Gwendolyn J. H. Lim, Warintorn Thitsartarn, Yong‐Wei Zhang, Zhigen Yu, Chaobin He   +10 more
wiley   +1 more source

Poly(Ionic Liquid)s Dispersants for Lubricants: A Review on Structure-Property Relationships. [PDF]

ACS Omega
Nik Fauzi NNA, Lim J, Matthews L, Ku Ishak KM, Shafiq MD.   +4 more
europepmc   +1 more source

ESCRT‐Mimetic Nanodegrader Targets STING for Anti‐Inflammatory Therapy

Advanced Science, EarlyView.
A nanoplatform‐enabled targeted protein degradation strategy is presented to regulate aberrant STING signaling. STING‐ATTEC induces selective autophagic degradation of STING via formation of a STING–ATTEC–LC3 ternary complex, while the cationic FA‐LNP+ system enhances LC3 generation and targeted delivery. Together, this synergistic approach efficiently
Fuyuan Zhou, Qiming Zhai, Zhihao Yao, Qing Li, Yan Yang, Si Wang, Chao Huang, Liangjing Xin, Tao Chen, Jinlin Song   +9 more
wiley   +1 more source

One-pot multi-substrate screening of ligation reactions using PNA tags. [PDF]

Chem Sci
Kohyama A, Barluenga S, Winssinger N.
europepmc   +1 more source