ChemistrySelect, Volume 10, Issue 25, July 4, 2025.Piperazine derivatives 2b, 2f, and 2h reduce neuroinflammation, oxidative stress, and memory impairment by modulating COX‐2, p‐NF‐κB, and TNF‐α pathways, showing promise as lead compounds for neurodegenerative disease drug development. Abstract Oxidative stress‐induced neuro‐inflammatory events are common in neurodegenerative illnesses, addressing ...
Sadaf Fardoos +8 more
wiley +1 more source
Harnessing biocatalysis as a green tool in antibiotic synthesis and discovery. [PDF]
RSC AdvBiocatalysis offers a sustainable approach to drug synthesis, leveraging the high selectivity and efficiency of enzymes. This review explores the application of biocatalysis in the early-stage synthesis of antimicrobial compounds, emphasizing its ...
Fernandes GFS, Kim SH, Castagnolo D.
europepmc +3 more sources
Selectivity on-target of bromodomain chemical probes by structure-guided medicinal chemistry and chemical biology [PDF]
, 2016 Targeting epigenetic proteins is a rapidly growing area for medicinal chemistry and drug discovery. Recent years have seen an explosion of interest in developing small molecules binding to bromodomains, the readers of acetyl-lysine modifications.
Alessio Ciulli +3 more
core +2 more sources
Benzochalcogenodiazoles, Synthesis, and Applications in Medicinal Chemistry and Photomedicine
European Journal of Organic Chemistry, Volume 28, Issue 23, June 23, 2025.Benzochalcogenodiazoles (BXD) including benzoxadiazoles, benzothiadiazoles, and benzoselenadiazoles are initially mainly designed for optoelectronic materials as electron‐deficient cores. Nevertheless, they are now extending their application to biology.
Jean‐Elie Zheng +2 more
wiley +1 more source
An investigation of Ru(II) complexes containing sterically demanding imido ligands : a thesis presented to Massey University in partial fulfilment of the requirements for the degree of Master of Science [PDF]
, 1995 Monomeric, low oxidation state, ruthenium imido compounds, (η6 -arene) RuN-Ar' (arene= p-cymene and C6 Me6 ; Ar'= 2,4,6-tri-tert-butylphenyl) have been synthesized from [(η6 -arene) RuCl2 ]2 and 4 equiv of LiNHAr' in THF.
Steedman, Andrew John
core
Design, synthesis and biological evaluation of novel coumarin-based benzamides as potent histone deacetylase inhibitors and anticancer agents [PDF]
, 2017 Histone deacetylases (HDACs) are attractive therapeutic targets for the treatment of cancer and other diseases. It has four classes (I-IV), among them especially class I isozyme are involved in promoting tumor cells proliferation, angiogenesis ...
Abdizadeh, Rahman. +7 more
core +1 more source
Irreversible inhibitors and activity-based probes as research tools in chemical glycobiology [PDF]
, 2011 In this review, we will discuss the enzymes that are involved in the synthesis and degradation of glycoconjugates and we will give an overview of the inhibitors and activity-based probes (ABPs) that have been used to study these.
Aerts, Johannes M.F.G. +3 more
core +2 more sources
La click-chemistry en el descubrimiento de fármacos [PDF]
, 2016 La revisión bibliográfica que se presenta a continuación trata sobre la llamada clickchemistry y su aplicación en el descubrimiento de fármacos. Para ello se parte de la definición de click-chemistry y sus principales características que la hacen ...
González Vázquez, María
core
COMPARATIVE APPROACHES FOR PLANT GENOMES: UNRAVELING "INTRA" AND "INTER" SPECIES RELATIONSHIPS FROM PRELIMINARY GENE ANNOTATIONS [PDF]
, 2016 Comparative genomics studies the differences and similarities between different species, to transfer biological information from model organisms to newly sequenced genomes, and to understand the evolutionary forces that drive changes in genomic features ...
Ambrosino, Luca
core
Introducing Small Rings into Farnesyl Pyrophosphates Paves the Way for the Enzymatic Generation of Unnatural Sesquiterpene Scaffolds. [PDF]
J Am Chem SocTaser D +8 more
europepmc +1 more source