Results 31 to 40 of about 3,627 (132)

Mode‐of‐Action and Human Relevance Assessment for Diisononyl Phthalate‐Induced Liver Tumors in Rodents

Journal of Applied Toxicology, EarlyView.
ABSTRACT Diisononyl phthalate (DINP) is a high molecular weight phthalate and high production volume chemical. DINP's carcinogenic potential has been investigated in four rodent bioassays, with liver tumors observed in three of the studies. Authoritative assessments have hypothesized that DINP acts through the peroxisome proliferator‐activated receptor
Amanda N. Buerger, Melissa M. Heintz, Laurie C. Haws, Chad M. Thompson   +3 more
wiley   +1 more source

Review of QSAR Models and Software Tools for predicting Acute and Chronic Systemic Toxicity [PDF]

, 2010
Information on acute and chronic systemic toxicity, arising from the oral, dermal and inhalation routes of exposure, are key elements in the regulatory assessment of chemicals. Traditionally, this information is obtained from animal studies. However, due
FUART GATNIK Mojca, LAPENNA Silvia, WORTH Andrew   +2 more
core   +1 more source

Gene turnover in the common ancestor of all C4 grasses

PLANTS, PEOPLE, PLANET, EarlyView.
Understanding how plants evolve more efficient photosynthesis is important in a warming world where improving crop productivity and resilience is a global priority. By generating the first reference genomes for an early‐diverging group of grasses called the Aristidoideae, we were able to reconstruct the genetic makeup of the last common ancestor of all
Lara Pereira, Ahmed S. Alenazi, Sahr Mian, Ilia J. Leitch, Pascal‐Antoine Christin, Colin P. Osborne, Luke T. Dunning   +6 more
wiley   +1 more source

Phosphoramidates and phosphonamidates (ProTides) with antiviral activity [PDF]

, 2018
Following the first report on the nucleoside phosphoramidate (ProTide) prodrug approach in 1990 by Chris McGuigan, the extensive investigation of ProTide technology has begun in many laboratories.
Arbelo RC, Cha A, Chen C-L, Fabrizio Pertusati, Jonckers THM, Magdalena Slusarczyk, Matthews SJ., Michaela Serpi, Saboulard D, Vig R   +9 more
core   +2 more sources

Covalent drug discovery: Progress against key targets, emerging strategies and lessons learnt

British Journal of Pharmacology, EarlyView.
Abstract Covalent drug discovery is currently experiencing a boom in industrial and academic interest. To date, at least 75 covalent drugs have received regulatory approval, targeting both traditional target classes and more challenging proteins for which other approaches failed. In many cases, unique aspects of covalent targeting are essential for the
Charles P. Brown, Alan Armstrong, David J. Mann   +2 more
wiley   +1 more source

Structure and catalytic properties of human glutathione transferase p1-1 [PDF]

, 2013
Glutathione transferases (EC 2.5.1.18, GSTs) catalyze the nucleophilic attack of glutathione (GSH) on the electrophilic centre of a number of electrophilic compounds helping to detoxify a diverse array of toxic xenobiotics including carcinogenic, and ...
Chatzikonstantinou, Marianna, Chronopoulou, Evangelia, Labrou, Nikolaos E., Madesis, Panagiotis, Nianiou-Obeidat, Irini   +4 more
core  

The past and future of enzyme measurements using surface enhanced Raman spectroscopy [PDF]

, 2010
The ability to accurately and sensitively measure the activity of specific enzymes is central to many aspects of modern chemistry and when combined with new nanoscience based approaches, offers significant opportunities for advancing other scientific ...
Bailo, Baker, Banholzer, Benkovic, Bjerneld, Bonifacio, Bonifacio, Broderick, Campbell, Chourpa, Cohen, Constantino, Copeland, Cui, Dick, Dieringer, Dieringer, Dou, Enright, Etchegoin, Etchegoin, Faulds, Faulds, Fleischmann, Garcia-Viloca, Gole, Gorris, Graham, Hawi, Hedstrom, Hrabakova, Ingram, Ingram, Ingram, Ingram, International Human Genome Sequencing Consortium, Jarvis, Johnson, Kneipp, Kneipp, Lal, Le Ru, Macaskill, Mantelingu, McAnally, McHugh, Min, Moore, Morjani, Moskovits, Moskovits, Murgida, Murza, Nie, Otto, Pieczonka, Pieczonka, Pieczonka, Rissin, Rohr, Rondelez, Rospendowski, Ruan, Sharma, Shin, Stevenson, Tang, Thompson, Todorovic, Wahler, Wu, Xiao, Xiao, Xiao, Xiao, Xu, Yue, Zhao, Zhou   +78 more
core   +1 more source

Protein Language Model‐Guided Engineering of a 2,3‐Butanediol Dehydrogenase for the Enantioselective Synthesis of Cyclic α‐Hydroxy Ketones

Advanced Science, Volume 13, Issue 18, 27 March 2026.
A (2R,3R)‐butanediol dehydrogenase from Bacillus subtilis (BsBDH) is engineered for the enantioselective synthesis of 2‐hydroxycyclohexanone. A PASS computational design strategy is proposed to enhance the thermostability of BsBDH. Moreover, ESM‐1v combined with ISM is utilized for enhancing and inverting its stereoselectivity.
Haote Ding, Ling Jiang, Yijia Song, Zhongji Pu, Lirong Yang, Haoran Yu   +5 more
wiley   +1 more source

Design, synthesis and biological evaluation of novel coumarin-based benzamides as potent histone deacetylase inhibitors and anticancer agents [PDF]

, 2017
Histone deacetylases (HDACs) are attractive therapeutic targets for the treatment of cancer and other diseases. It has four classes (I-IV), among them especially class I isozyme are involved in promoting tumor cells proliferation, angiogenesis ...
Abdizadeh, Rahman., Abdizadeh, Tooba., Abnous, Khalil., Ghodsi, Razieh., Hadizadeh, Farzin., Kalani, Mohammad Reza., Khashyarmanesh, Bibi Zahra., Tayarani-Najaran, Zahra.   +7 more
core   +1 more source

Harmine Derivatives as Anticancer Agents Endowed With Potent and Selective Antileukemia Activity: Synthesis, Biological Evaluation, Proapoptotic and Genotoxic Activity

Archiv der Pharmazie, Volume 359, Issue 2, February 2026.
We identified a novel N9‐substituted harmine analog, compound 6, that selectively suppresses leukemic cell growth, triggers DNA damage, and activates apoptosis while sparing healthy fibroblasts. This discovery highlights N9‐modified β‐carbolines as a powerful new class of selective antileukemic agents, bridging natural product chemistry with next ...
Abdul Aziz Timbilla, Filip Pidany, Eliska Kohelova, Jana Kroustkova, Karel Kralovec, Jan Rataj, Martina Ceckova, Negar Maafi, Víctor Lopez, Cristina Moliner Langa, Stefan Kosturko, Jaroslav Jenco, Darina Muthna, Darja Koutova, Martina Rezacova, Lucie Cahlikova, Jakub Chlebek, Radim Havelek   +17 more
wiley   +1 more source