Results 11 to 20 of about 1,988 (88)

Characterization of enzyme activities and cofactors involved in bioactivation and bioinactivation of chemical carcinogens in the tester strains Escherichia coli K12 MX100 and Salmonella typhimurium LT2 TA100. [PDF]

, 1997
MX100 is an Escherichia coli K12 genotoxicity tester strain, especially developed for mechanistic studies of chemical mutagens and carcinogens. For the study of the role of specific enzymes in the bioactivation and bioinactivation of carcinogens, it is ...
Rueff, J., Laires, A., Vermeulen, N.P.E.; id_orcid, Vermeulen, N.P.E., Kranendonk, M., Commandeur, J.N.M.   +5 more
core   +1 more source

Homozygous gene deletions of the glutathione S-transferases M1, and T1 are associated with thimerosal sensitization

, 2000
Objective: Thimerosal is an important preservative in vaccines and ophthalmologic preparations. The substance is known to be a type IV sensitizing agent.
Bauer, A., Szliska, Christiane, Schulz, Thomas G., Koch, P., Hallier, Ernst, Reich, Kristian, Schnuch, Axel, Aberer, Werner, Wessbecher, R., Westphal, Goetz Alexander, Brasch, Jochen   +10 more
core   +1 more source

In silico prediction of human carboxylesterase-1 (hCES1) metabolism combining docking analyses and MD simulations

, 2010
Metabolic problems lead to numerous failures during clinical trials, and much effort is now devoted in developing in silico models predicting metabolic stability and metabolites.
G. Vistoli, A. Pedretti, Vistoli, G., Pedretti, A., Mazzolari, A., A. Mazzolari, Testa, B., B. Testa   +7 more
core   +1 more source

Biocatalytic organofluorine synthesis via hemoprotein-catalyzed carbene transfer reactions

, 2021
Thesis (Ph. D.)--University of Rochester. Department of Chemistry, 2020.Protein engineering efforts in our laboratory led to the development of efficient hemoprotein-based biocatalysts for abiological carbene transfer reactions.
Fasan, Rudi, Tinoco Valencia, Antonio
core  

Deprotective Functionalization: An Emerging Concept for Amine Reactivity

Chemistry – A European Journal, Volume 32, Issue 4, 23 January 2026.
While protecting groups are indispensable in total synthesis to avoid undesired reactivity, installation and removal of protecting groups lead to an increase in the step‐count, cost, waste production and time requirement. One approach tackling these drawbacks is deprotective functionalization, which combines deprotection and postfunctionalization in a ...
Irmgard Tiefenbrunner, Saad Shaaban, Nuno Maulide   +2 more
wiley   +1 more source

A Modular Biosensor Platform for the Detection of Plastic Monomers and the Engineering of Promiscuous Amidases Toward Challenging Substrates

Advanced Science, Volume 13, Issue 6, 30 January 2026.
A luciferase is used as biosensor for aldehydes, produced enzymatically from different monomeric building blocks of plastics like polyurethanes (PUs). The screening platform is used to monitor esterase, amidase, and urethanase activity and to guide the selection of enzyme variants with improved hydrolytic activities toward difficult to hydrolyze ...
Ina Somvilla, Hannah Meier, Florian Oehlschläger, Hannes Meinert, Lena Koch, Patrick Ihrle, Katharina M. Mehnert, Morten Flieger, Jonas Boß, Marco Seifert, Dominique Böttcher, Uwe T. Bornscheuer, Thomas Bayer   +12 more
wiley   +1 more source

Procyanidin B3 and Its Derivatives Alleviate Neuronal Injury by Targeting G3BP1 for Ischemic Stroke Therapy

Advanced Science, Volume 12, Issue 45, December 4, 2025.
Ischemic stroke is a serious disease with high rates of mortality and disability, but there is a lack of novel therapeutic targets and agents for it. Now it is shown that Ras GTPase‐activating protein SH3 domain‐binding protein 1 (G3BP1) has the potential to serve as a therapeutic target for ischemic stroke.
Heyanhao Zhang, Yuyu Zhang, Yibo Chen, Wen Zhong, Subei Tan, Jinghuan Wang, Huanren Yan, Ning Yan, Mengjia Lin, Xinhua Liu, Jun Chang   +10 more
wiley   +1 more source

Opportunities When Chemistry Meets Biology in Catalysis and Synthesis

Transformative Chemistry, Volume 1, Issue 1, December 2025.
Biosynthesis and chemical synthesis possess complementary strengths and limitations. Integrating these two systems across multiple levels offers opportunities for molecular synthesis to become highly efficient, precise, versatile, and scalable in the future, while also ensuring environmental compatibility and resource renewability.
Xiao Xiao, Xinyi Ren, Baoguo Zhao, Xiaoguang Lei, Wen Liu, Kuiling Ding   +5 more
wiley   +1 more source

Cobalamin‐Dependent Aryl Methyl Ether O‐Demethylases: Promising Enzymes for Biocatalytic Applications from Lignin Valorization to Organic Synthesis

ChemCatChem, Volume 17, Issue 21, November 10, 2025.
Cobalamin‐dependent aryl methyl ether O‐demethylases have high potential for biocatalytic applications, including lignin valorization and synthetic chemistry. In this review, we provide a detailed overview of such O‐demethylase systems identified to date from various microorganisms, including their mechanism, substrate scope and selectivity, and ...
Niels Krabbe Johnsen, Santipap Chaiyasarn, Zheng Guo, Jaehong Han, Bekir Engin Eser   +4 more
wiley   +1 more source

Origin and characterization of cyclodepsipeptides: Comprehensive structural approaches with focus on mass spectrometry analysis of alkali‐cationized molecular species

Mass Spectrometry Reviews, Volume 44, Issue 6, Page 1013-1098, November/December 2025.
Abstract Cyclodepsipeptides (CDPs) represent a huge family of chemically and structurally diverse molecules with a wide ability for molecular interactions. CDPs are cyclic peptide‐related natural products made up of both proteinogenic and nonproteinogenic amino acids linked by amide and ester bonds.
Sophie Liuu, Annelaure Damont, Alain Perret, Olivier Firmesse, François Becher, Gwenaëlle Lavison‐Bompard, Amandine Hueber, Amina S. Woods, Ekaterina Darii, François Fenaille, Jean‐Claude Tabet   +10 more
wiley   +1 more source