Results 11 to 20 of about 2,022 (94)

Amide and Thioester Synthesis Via Oxidative Coupling of Alcohols with Amines or Thiols Using Alcohol Dehydrogenases. [PDF]

Angew Chem Int Ed Engl
Alcohol dehydrogenases (ADHs) are best known for reducing ketones to chiral alcohols, but their oxidative potential is rarely exploited. Here, we show that selected ADHs catalyze newly discovered promiscuous transformations: the oxidative coupling of primary alcohols with amines or thiols, enabling the direct and efficient synthesis of a broad range of
Damian M, Tseliou V, Peters P, Knaus T, Mutti FG.   +4 more
europepmc   +3 more sources

Merging Biocatalysis and Chemocatalysis in Flow: State-of-the-Art and Future Directions for Sustainable Synthesis. [PDF]

Angew Chem Int Ed Engl
This review highlights recent advances in integrating biocatalysis and chemocatalysis in continuous flow to create streamlined, sustainable processes. It examines chemo‐enzymatic cascades combining at least one enzymatic and one chemical step, discusses challenges such as enzyme immobilization, leaching, and reactor clogging, and presents solutions ...
Siasiaridis P, Damian M, Mutti FG.
europepmc   +3 more sources

Gene turnover in the common ancestor of all C4 grasses

PLANTS, PEOPLE, PLANET, EarlyView.
Understanding how plants evolve more efficient photosynthesis is important in a warming world where improving crop productivity and resilience is a global priority. By generating the first reference genomes for an early‐diverging group of grasses called the Aristidoideae, we were able to reconstruct the genetic makeup of the last common ancestor of all
Lara Pereira, Ahmed S. Alenazi, Sahr Mian, Ilia J. Leitch, Pascal‐Antoine Christin, Colin P. Osborne, Luke T. Dunning   +6 more
wiley   +1 more source

Covalent drug discovery: Progress against key targets, emerging strategies and lessons learnt

British Journal of Pharmacology, EarlyView.
Abstract Covalent drug discovery is currently experiencing a boom in industrial and academic interest. To date, at least 75 covalent drugs have received regulatory approval, targeting both traditional target classes and more challenging proteins for which other approaches failed. In many cases, unique aspects of covalent targeting are essential for the
Charles P. Brown, Alan Armstrong, David J. Mann   +2 more
wiley   +1 more source

Photoreactive Pantetheinyl Mimics Reveal Design Limitations for Crypto‐Acyl Carrier Proteins

ChemBioChem, Volume 27, Issue 18, 28 September 2026.
Probes were rationally designed to capture key intramolecular interactions thorugh photocrosslinking in thiotemplated assembly lines: polyketide synthases (PKS), fatty acid synthases (FAS), and non‐ribosomal peptide synthetases (NRPS). Poor or no crosslinking was observed from these probes, highlighting current limitations of synthetic and structural ...
Anna‐Kay R. West, Tawakalitu A. Afolabi‐Balogun, Christian C. Martin, Lizbeth Cambron, Mujeeb A. Wakeel, Joshua A. Baccile, Constance B. Bailey   +6 more
wiley   +1 more source

Synthesis of Glycopeptide Antibiotic Peptide Substrates Using Knorr‐Pyrazole Chemistry

ChemMedChem, Volume 21, Issue 17, 14 September 2026.
The glycopeptide antibiotics (GPAs) are important clinical antibiotics. While chemoenzymatic synthesis of more hydrophilic GPAs like vancomycin has aided our understanding of GPA crosslinking, hydrophobic GPAs remain underexplored. Here, we show that modified Knorr‐pyrazole chemistry improves access to hydrophobic peptidyl‐CoAs, with such substrates ...
Jemma Gullick, W. Ramani H. Weerasinghe, Ralf B. Schittenhelm, Julien Tailhades, Max J. Cryle   +4 more
wiley   +1 more source

Stereodivergent Synthesis of C5‐α‐Substituted Linezolid Derivatives From D‐Mannitol and Structure–Antibacterial Activity Evaluation

Chirality, Volume 38, Issue 9, September 2026.
A stereodivergent route from D‐mannitol enables access to enantiopure C5‐α‐substituted linezolid analogues with full configurational control. Biological evaluation reveals that α‐substitution abolishes antibacterial activity irrespective of stereochemistry, establishing a strict steric limitation at C5 and highlighting the dominant role of substituent ...
José A. Gálvez, Laura Sanz‐Asensio, Ramón Badorrey, Jesús Gonzalo‐Asensio   +3 more
wiley   +1 more source

A Review on Green Synthetic Approaches in the Development of Quinoline Analogues

ChemistrySelect, Volume 11, Issue 33, 1 September 2026.
This review highlights recent advances in environmentally friendly approaches, including metal‐free systems, solvent‐free approaches, microwave, and ultrasonic‐assisted techniques, organo‐ and biocatalysis, ionic liquids, nanoparticle catalysis, electrochemical, and photocatalytic strategies for the synthesis of quinoline scaffolds.
Demis Zelelew, Ajay Bissessur, Parvesh Singh, Hogantharanni Govender   +3 more
wiley   +1 more source

Comprehensive Review on Green Transformation of Organic Waste Into Bioenergy Using Microbial Enzymes: Advances, Challenges, and Future Strategies

GCB Bioenergy, Volume 18, Issue 9, September 2026.
Microbial enzyme‐mediated biorefineries enable the sustainable conversion of organic waste into renewable bioenergy and value‐added products. Recent advances on enzymatic pretreatment, enzyme cocktails, and hybrid processing enhance biogas, bioethanol, and biodiesel production, along with supporting efficient waste valorization, circular bioeconomy ...
Divya Divakaran, Indran Suyambulingam, Ananth Selvan, Nadir Ayrilmis, P. Merlin Christy, M. Gomathi, P. Senthamaraikannan   +6 more
wiley   +1 more source

Targeting Human Immunodeficiency Virus Integrase Beyond the Active Site: The Discovery and Development of Allosteric Integrase Inhibitors

ChemMedChem, Volume 21, Issue 16, 27 August 2026.
Human immunodeficiency virus (HIV) allosteric integrase inhibitors (ALLINIs) offer a vital alternative to standard therapies by targeting noncatalytic sites. By inducing aberrant integrase multimerization, they disrupt viral maturation. This review explores their medicinal chemistry evolution, detailing structural insights, structure–activity ...
Francesco Saccoliti, Elisa Patacchini, Emanuele Cara, Laura Zarbo, Antonella Messore, Aurora Albano, Giuseppe Ruggieri, Valentina Noemi Madia, Luigi Scipione, Roberta Costi, Roberto Di Santo   +10 more
wiley   +1 more source