Results 1 to 10 of about 1,982 (88)

Merging Biocatalysis and Chemocatalysis in Flow: State-of-the-Art and Future Directions for Sustainable Synthesis. [PDF]

Angew Chem Int Ed Engl
This review highlights recent advances in integrating biocatalysis and chemocatalysis in continuous flow to create streamlined, sustainable processes. It examines chemo‐enzymatic cascades combining at least one enzymatic and one chemical step, discusses challenges such as enzyme immobilization, leaching, and reactor clogging, and presents solutions ...
Siasiaridis P, Damian M, Mutti FG.
europepmc   +3 more sources

Amide and Thioester Synthesis Via Oxidative Coupling of Alcohols with Amines or Thiols Using Alcohol Dehydrogenases. [PDF]

Angew Chem Int Ed Engl
Alcohol dehydrogenases (ADHs) are best known for reducing ketones to chiral alcohols, but their oxidative potential is rarely exploited. Here, we show that selected ADHs catalyze newly discovered promiscuous transformations: the oxidative coupling of primary alcohols with amines or thiols, enabling the direct and efficient synthesis of a broad range of
Damian M, Tseliou V, Peters P, Knaus T, Mutti FG.   +4 more
europepmc   +3 more sources

Characterization of enzyme activities and cofactors involved in bioactivation and bioinactivation of chemical carcinogens in the tester strains Escherichia coli K12 MX100 and Salmonella typhimurium LT2 TA100. [PDF]

, 1997
MX100 is an Escherichia coli K12 genotoxicity tester strain, especially developed for mechanistic studies of chemical mutagens and carcinogens. For the study of the role of specific enzymes in the bioactivation and bioinactivation of carcinogens, it is ...
Rueff, J., Laires, A., Vermeulen, N.P.E.; id_orcid, Vermeulen, N.P.E., Kranendonk, M., Commandeur, J.N.M.   +5 more
core   +1 more source

Homozygous gene deletions of the glutathione S-transferases M1, and T1 are associated with thimerosal sensitization

, 2000
Objective: Thimerosal is an important preservative in vaccines and ophthalmologic preparations. The substance is known to be a type IV sensitizing agent.
Bauer, A., Szliska, Christiane, Schulz, Thomas G., Koch, P., Hallier, Ernst, Reich, Kristian, Schnuch, Axel, Aberer, Werner, Wessbecher, R., Westphal, Goetz Alexander, Brasch, Jochen   +10 more
core   +1 more source

In silico prediction of human carboxylesterase-1 (hCES1) metabolism combining docking analyses and MD simulations

, 2010
Metabolic problems lead to numerous failures during clinical trials, and much effort is now devoted in developing in silico models predicting metabolic stability and metabolites.
G. Vistoli, A. Pedretti, Vistoli, G., Pedretti, A., Mazzolari, A., A. Mazzolari, Testa, B., B. Testa   +7 more
core   +1 more source

Biocatalytic organofluorine synthesis via hemoprotein-catalyzed carbene transfer reactions

, 2021
Thesis (Ph. D.)--University of Rochester. Department of Chemistry, 2020.Protein engineering efforts in our laboratory led to the development of efficient hemoprotein-based biocatalysts for abiological carbene transfer reactions.
Fasan, Rudi, Tinoco Valencia, Antonio
core  

Alkyltransferase Ribozyme for Site-Specific N⁴-Cytidine Alkylation. [PDF]

Angew Chem Int Ed Engl
Dorinova E, Walunj MB, Höbartner C.
europepmc   +1 more source

Basic importance: mechanistic molecular modeling of the <i>ent</i>-copalyl diphosphate synthase from <i>Arabidopsis thaliana</i> (AtCPS). [PDF]

Org Biomol Chem
Torrence IS, Peters RJ, Siegel JB, Tantillo DJ.   +3 more
europepmc   +1 more source

Designed Water Capture in Terpene Synthase Catalysis. [PDF]

Chembiochem
Srivastava PL, Miller DJ, Allemann RK.
europepmc   +1 more source

Peeking behind the carbocation: identification of (alternative) catalytic bases in the class II active site of conifer resin acid diterpene synthases. [PDF]

Biochem J
Raslan AMAA, Peters RJ.
europepmc   +1 more source